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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 37 (1989), S. 85-90 
    ISSN: 1432-1041
    Keywords: theophylline ; sustained-release formulation ; bioavailability ; fatty food ; dumping effect ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A cross-over study of kinetics has been undertaken in 12 healthy adults volunteers using two sustained-release theophylline products that allow once a day dosing (Theo-Dur tablets and Dilatrane A.P. bead filled capsules) to compare the i.v. pharmacokinetic profiles when taken with an hyperlipidic meal and a balanced standard meal. Each subject took part in four phases in randomised order, corresponding to all possible combinations of the products and the types of meal. Each phase involved a single dose of 9 to 11 mg·kg−1 theophylline administered at 20.00 h, at the beginning of the meal, with 100 ml water. The two formulations were found to be bioequivalent with both types of meal. Taken with a balanced meal, the mean parameters were similar; for Theo-Dur and Dilatrane A.P. they were respectively: Cmax: 11.32 mg·l−1 which plateaued from 8 to 10 h after dosing and 10.9 mg·l−1, which plateaued after 6 to 10 h; AUC 230 mg·h·l−1 and 220 mg·h·l−1; and MRT 18.2 h and 17.7 h. After the hyperlipidic meal the values for Theo-Dur and Dilatrane A.P. respectively, were: Cmax 10.9 mg·l−1 at 12 h and 11.3 mg·l−1 at 10 h; AUC 237 mg·h·l−1 and 227 mg·h·l−1; and MRT 19.2 h and 18.9 h. In spite of a decrease in the absorption rate, which led to a shift to the right of about 2 h of the plasma concentration-time curve, the bioavailability of both formulations were not significantly modified by a hyperlipidic meal as compared to a balanced meal. The shift of the curve with fatty food was not clinically important, as there was no dumping effect. The main difference between the two formulations was seen during the absorption phase, which was linear and less variable with Dilatrane A.P. and sigmoidal with Theo-Dur. This was observed with both types of meal.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 27 (1984), S. 325-328 
    ISSN: 1432-1041
    Keywords: theophylline ; sustained release ; pharmacokinetics ; chronic administration ; healthy volunteers ; plasma levels ; GCMS assay ; stable isotope technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of a new sustained-release preparation of theophylline (Dilatrane à Action Prolongée capsules filled with homogenous microgranules) has been after its studied administration to 7 healthy volunteers at 8 p.m. in order to achieve therapeutic levels at night and in the morning. In separate trials the test dose of 500 or 600 mg was administered for 7 days, once daily at 8 p.m. Plasma theophylline levels were measured by capillary gas chromatography with a mass specific detector after pentylation, using internal standards labelled with stable isotopes (15N-1,3 and 13C-2 theophylline). The new sustained-release preparation showed a monophasic regular absorption phase with very low interindividual variability. After administration, the plasma level stayed within 80% of the peak levels for 8.5±1.5 h. There was a good correlation between the dose and the steady state plasma level (r=0.9587; p〈0.05). This preparation can be chronically administered once daily day at 8 p.m. in order to achieve a therapeutic level during the night and the morning, and to provide sufficient protection during the nycterohemeral period, with a once dose a day schedule.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 167 (1951), S. 406-407 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It has long been clear that the selective extraction of coal by good solvents such as pyridine differs from the almost complete solution which is obtained at higher temperatures, for example above 350 C. with hydrocarbons such as phenanthrene and about 290 C. with naphthols. In selective ...
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0371-1951
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Microchimica acta 58 (1970), S. 855-863 
    ISSN: 1436-5073
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Iridium, Osmium und Ruthenium lassen sich katalytisch nach der vonSandell undKolthoff vorgeschlagenen Methode der Jodidbestimmung quantitativ ermitteln. Über die Wirkung einiger Parameter auf die katalysierte Cer(IV)-Arsen(III)-Reaktion wurde berichtet und ein brauchbares Verfahren beschrieben, das mit folgenden Empfindlichkeiten anwendbar ist: 0,002 mg Ir/l, 0,2 mg Os/l und 0,005 mg Ru/l.
    Abstract: Summary Iridium, Osmium and Ruthenium are determined by the catalymetric method previously proposed bySandell andKolthoff for Iodide. The effects of some parameters on the catalysed Ce(IV)-As(III) reaction are reported and a reliable procedure is described for each element, with the following sensitivities: Iridium: 0,002 mg/l, Osmium: 0,2 mg/l, Ruthenium: 0,005 mg/l.
    Notes: Résumé On propose d'appliquer au dosage de l'iridium, de l'osmium et du ruthénium, la méthode imaginée parSandell etKolthoff pour le dosage des iodures. L'influence de divers paramètres sur la vitesse de la réaction Ce(IV)-As(III) a fait l'objet d'une étude comparative qui a permis de définir de bonnes conditions de dosage et d'atteindre les sensibilités suivantes: Iridium: 0,002 mg/l, Osmium: 0,2 mg/l, Ruthénium: 0,005 mg/l.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1436-5073
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Eine Methode zur Bestimmung von Platin in Konzentrationen von ng/ml wurde beschrieben. Dazu wird das Pt durch Amalgamierung mit Quecksilber abgetrennt, wonach diese beiden Elemente mit Formiat gemeinsam reduziert werden. Nach Entfernung des Quecksilbers durch Verdampfen und Auflösen des Rückstandes in Königswasser wird das Pt neuerlich in Gegenwart von Gold reduziert, das als Träger fungiert, wobei man eine stabile kolloidale Lösung erhält. Die Bestimmung des Pt erfolgt durch Messung der katalytischen Wirkung dieser Lösung bei der Entfärbung von Methylenblau durch Formiat.
    Abstract: Summary A method is described which permits measurements of platinum in concentrations in the region of nanograms per liter. It consists of separating the platinum by amalgamation with mercury, the two elements being reduced by formate in a homogeneous medium. After elimination of the mercury by volatilization and dissolving the residue in aqua regis, the platinum is reduced once more by formate in the presence of gold. The gold plays a supporting role and enables a stable colloidal solution to be obtained. The determination of platinum is based on measurement of the catalytic power of this solution with regard to the reaction of decoloration of methylene blue by formate.
    Notes: Résumé On décrit une méthode permettant de doser le platine à des concentrations voisines du nanogramme par millilitre. Elle consiste à séparer le platine par amalgamation avec le mercure, ces deux èléments étant réduits par le formiate en milieu homogène. Après élimination du mercure par volatilisation et dissolution du résidu dans 1'eau régale, le platine est à nouveau réduit par le formiate en présence d'or qui joue le rôle de support et permet d'obtenir une solution colloïdale stable. Le dosage du platine est basé sur la mesure du pouvoir catalytique de cette solution vis-à-vis de la réaction de décoloration du bleu de méthylène par le formiate.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 247 (1969), S. 163-165 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Résumé On a mis au point une méthode de dosage de traces de Cr en solution aqueuse. Le méthode consiste à former l'oxinate de Cr(III), à l'extraire à l'aide d'oxine fondue, puis à le doser, par spectrophotométrie de sa solution chloroformique à 420 nm. La méthode est relativement spécifique et sa sensibilité peut atteindre quelques parties par milliard. On présente des exemples d'applications aux produits sodiques.
    Notes: Abstract A method is described for the determination of Cr in aqueous solutions. It is based on the formation of Cr(III) oxinate, its extraction by means of molten oxine and the spectrophotometric measurement of the chloroform solution at 420 nm. The method is relatively specific and the sensitivity is about 10−3 ppm. Several examples of application to sodium compounds are presented.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 254 (1971), S. 35-36 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' Zeitschrift für analytische Chemie 111 (1937), S. 283-284 
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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