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  • 1
    Electronic Resource
    Electronic Resource
    Calcium pyrophosphate-induced pleurisy in rats: A new model of acute inflammation (1994)
    Springer
    Inflammation research 43 (1994), S. 221-224 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A model is described of acute inflammation in the pleural cavity of rats using calcium pyrophosphate as the irritant. This model would seem to simulate the pseudogout syndrome. It has been shown to be acute in onset, dominated by polymorphonuclear cells, complement independent. The advantage of the model is that volume of exudate, numbers and types of cells may be quantitated. Prostaglandins and cyclic AMP have been measured in the migrating cells. The significance of these findings has been discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01986693
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  • 2
    Electronic Resource
    Electronic Resource
    Modulation of polymorphonuclear leukocyte responsiveness by copper (II)2 (niflumate)4 (1995)
    Springer
    Inflammation research 44 (1995), S. 198-203 
    Details
    ISSN: 1420-908X
    Keywords: Pleurisy ; Burn ; Polymorphonuclear ; Copper niflumate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Antiinflammatory activities and modulations of PMNL responses produced by treatment with tetrakis-μ-2-[3-(trifluoromethyl)-phenyl] aminonicotinatodicopper (II) [Cu(II)2(niflumate)4] and niflumic acid were studied in isologous serum-induced rat pleurisy. Doses of 10 or 30 mg/kg (35 or 106 µmol/kg) of niflumic acid or Cu(II)2 (niflumate)4 (8 or 23 µmol/kg) caused significant (p 〈 0.01) reductions in pleural exudate and number of polymorphonuclear leukocytes (PMNLs) in the exudate. While both doses of Cu(II)2(niflumate)4 produced significant dose-related reductions in both parameters, only the higher dose of niflumic acid produced a significant dose-related reduction in both parameters. Boyden chamber measurements of N-formyl-methionyl-leucyl-phenylalanine (f-MLP) chemotaxis by PMNLs incubated with 10 or 30 µg/ml niflumic acid (35 or 106 nmol/ml) or Cu(II)2(niflumate)4 (8 or 23 nmol/ml) were significantly (p 〈 0.01 to p 〈 0.001) decreased in dose-related fashions. Chemotaxis of PMNLs from pleuritic rats treated orally with 10 or 30 mg/kg niflumic acid or Cu(II)2(niflumate)4 was significantly (p 〈 0.001) inhibited by the larger dose of niflumic acid and both doses of Cu(II)2(niflumate)4. Opsonized zymosan (OZ)-stimulated chemiluminescence (CL) of PMNLs from pleuritic rats treated orally with these same doses of niflumic acid or Cu(II)2(niflumate)4 was only significantly (p 〈 0.05 or p 〈 0.01 respectively) decreased by the larger doses. Superoxide (O 2 - ) production by these cells was significantly decreased by the larger dose of niflumic acid (p 〈 0.05) while both doses of Cu(II)2(niflumate)4 produced significant (p 〈 0.05 to p 〈 0.01) decreases. Recovery of the decreased PMNL response in burned rats was also studied following treatment with these two compounds. Oral treatment of non-burned rats with 1 mg/kg niflumic acid (4 µmol/kg) or Cu(II)2(niflumate)4 (1 µmol/kg) did not affect OZ-stimulated O 2 - production while decreased O 2 - production in non-treated scald-burned rats was reversed by oral treatment with either niflumic acid or Cu(II)2(niflumate)4. It is concluded that Cu(II)2(niflumate)4 is a more effective antiinflammatory agent than niflumic acid and more effective modulation of PMNL responsiveness may explain its beneficial antipleuritic and burn-injury recovery effects. Formation of the copper complex of niflumic acidin vivo may also account for its beneficial antiinflammatory effects and recovery of depressed PMNL responsiveness in burned rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01782258
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  • 3
    Electronic Resource
    Electronic Resource
    Calcium pyrophosphate-induced pleurisy in rats: A new model of acute inflammation (1975)
    Springer
    Inflammation research 5 (1975), S. 35-38 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A model is described of acute inflammation in the pleural cavity of rats using calcium pyrophosphate as the irritant. This model would seem to simulate the pseudogout syndrome. It has been shown to be acute in onset, dominated by polymorphonuclear cells, complement independent. The advantage of the model is that volume of exudate, numbers and types of cells may be quantitated. Prostaglandins and cyclic AMP have been measured in the migrating cells. The significance of these findings has been discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02027156
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  • 4
    Electronic Resource
    Electronic Resource
    Adjuvant-induced arthritis in four inbred strains of rats. An in vitro study of peripheral T and B lymphocytes (1976)
    Springer
    Inflammation research 6 (1976), S. 219-227 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The lymphoblastic response (LTT) to non-specific mitogens (PHA, PWM and CoA) of peripheral lymphocytes was investigated at days 0, 7, 14, 21 and 28 after adjuvant injection in four strains of inbred rats: Wistar (WAG), Long Evans (LE), Lewis (LEW) and Brown Norway (BN). LTT was assessed by using 18 hours H3 TdR incorporation in 5 days cultures of whole blood (micromethod). The statistical treatment of data, using principal components multifactorial analysis and analysis of variance showed a striking difference between strains. In control animals the responses to PHA and PWM were correlated and were higher in LE and WAG than in LEW and BN (BN=LEW〈LE=WAG). The response to ConA was independent of that to the other mitogens. It was generally low, but significantly higher in LEW and BN than in WAG and LE. In adjuvant-injected animals the responses to PHA and PWM were still correlated, but modified compared to control: in LE and LEW, but not in WAG and BN, a marked decrease of the response was found, reaching a minimum value within days 7 and 14. In the same time the response to ConA increased in the four strains, later in LE than in the others. However the intensity of the ConA response varied from one strain to another: it was constantly low in LE and WAG compared to LEW and BN. So the most striking modification of LTT were observed in LE and LEW, which both developed the most severe arthritis. However these different behaviours after adjuvant injection were not explained by the initial level of LTT to the different mitogens. These data suggest that the development of intense arthritis is associated with the proliferation and the release into the blood stream of a lymphocyte subpopulation, which exhibits a low response to PHA and PWM and a high response to ConA. These LTT modifications are not paralled by quantitative variations of B-cells assessed by surface Ig immunofluorescent staining and EAC rosetting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972212
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  • 5
    Electronic Resource
    Electronic Resource
    Anti-inflammatory properties of a novel wound healing and immunomodulating agent, tetrachlorodecaoxygen complex (TCDO) (1990)
    Springer
    Inflammation research 31 (1990), S. 368-374 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The first phase of the healing process is characterized by the development of an inflammatory reaction involving migration of inflammatory cells and release of inflammatory mediators. In a previous study, we have demonstrated that the water soluble tetrachlorodecaoxygen complex (TCDO), first synthetized to promote wound healing, inhibits polymorphonuclear (PMN) migration. The aim of the present study was to investigate the activity of TCDO on the progression of an acute non-specific inflammatory reaction, on the release of 6-keto-PGF1α and PGE2 and on PMN oxidative metabolism in the rat. Injected in the pleural cavity, TCDO (15 μmoles/rat) significantly decreased the number of exudative cells while 1.5 μmoles/rat inhibited PMN oxidative metabolismex vivo (assessed by chemiluminescent assay and measurement of O 2 − generation) after stimulation of the cells by opsonized zymosan. Similar observations were madein vitro after incubation of PMNs with various concentrations of TCDO (300 to 3 μM). The effect was dose-related and highly significant up to the concentration of 3 μM. In parallel, TCDO decreased the amounts of 6-keto-PGF1α and PGE2 in exudates harvested 1 hour after the intrapleural injection of isologous serum. Effects were significantly different from control levels, from 1.5 to 0.03 μmoles/rat for 6-keto-PGF1α and from 1.5 to 0.01 μmoles/rat for PGE2. This effect was observed when TCDO was injected at the same time or 1 hour before the isologous serum but not later. TCDO also inhibited LTB4 generationin vitro after PMN stimulation by calcium ionophore A23187, at concentrations up to 150 μM. The effects of TCDOin vivo andin vitro on rat PMN functions and inflammatory mediator release mimic certain activities of anti-inflammatory drugs. These properties may be beneficial in the very early stages of the wound healing process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01997633
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  • 6
    Electronic Resource
    Electronic Resource
    Induction of DNA synthesis in rat peritoneal macrophages in culture by a pleural inflammatory exudate (1976)
    Springer
    Inflammation research 6 (1976), S. 114-122 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Peritoneal macrophages in culture are blocked in the G0 phase of the cell cycle, but retain many of their functional characteristics such as phagocytic ability. Peritoneal macrophages have been thought to be a terminal cell type. It has been investigated whether such properties could be modified by a substance released in acute inflammatory exudates. For this purpose a pleural exudate obtained from rats injected with dextran (40,000) 4 hours before, was centrifuged to eliminate cells, sterilized by filtration on Millipore filter 0.22 μm and diluted 50% with 199 medium culture. This medium was used to treat normal and activated peritoneal macrophages in culture. The effects were observed 24, 48, 72, 96 hours after the beginning of treatment. An enhancement of spreading and capacity of phagocytosis was observed 24 hours after the beginning of treatment. After 48 hours, the number of cells incorporating tritiated thymidine increased and became highest 4 days later. These phenomena were also obtained with pleural exudate of inbred rats (Lewis, Wag) treating macrophages of the same strain and with rat pleural exudate treating mouse macrophages. No effects were observed with dextran alone. The chemical nature of the stimulatory factor remains to be elucidated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972194
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  • 7
    Electronic Resource
    Electronic Resource
    General closing remarks (1976)
    Springer
    Inflammation research 6 (1976), S. 377-380 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972259
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  • 8
    Electronic Resource
    Electronic Resource
    The mast cells of the newborn rat diaphragm and their response to histamine liberators (1975)
    Springer
    Inflammation research 5 (1975), S. 48-51 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The mast cell population of rat diaphragm was estimated between birth and adulthood and found to rise with an increase in the age of rat studied. Degranulation of these cells was observed in rats from all age groups, following treatment with compound 48/80 and dextran. The association of mast cells with the blood vessel wall in adult rat diaphragm was not observed in the comparable tissues of newborn rats. These findings are discussed in relationship to the poor vascular permeability reactions exhibited by newborn and young rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02027158
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  • 9
    Electronic Resource
    Electronic Resource
    In vitro effect of cetirizine on PGE2 release by rat peritoneal macrophages and human monocytes (1994)
    Springer
    Inflammation research 43 (1994), S. 13-16 
    Details
    ISSN: 1420-908X
    Keywords: Cetirizine ; Anti H1 ; PGE2 ; IL-1 ; Monocyte/macrophage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cetirizine was first described as a specific anti-H1 molecule displaying potent antiallergic activity. It was later found that its pharmacological properties extended to cellular actions as on eosinophil recruitment at inflammatory sites in allergic patients. Monocytes and macrophages participate in allergic mechanisms, particularly through high affinity H1 and H2 membrane receptors and generation of pro- and anti-inflammatory agents; among them histamine-induced factors, IL-1 and prostanoids are of importance. The aim of this work was to investigate the effect exerted by various concentrations of cetirizine (0.1–10 μg/ml) appliedin vitro to human monocytes and peritoneal rat macrophages cultured for 24 h. Peritoneal macrophages were collected either from normal or experimentally inflamed rats. Human monocytes, isolated from peripheral blood, were studied either in a resting state or after stimulation by LPS fromEscherichia coli (1 and 10 μg/ml). Cetirizine (10 μg/ml) significantly enhanced IL-1 release by human monocytes stimulated by a weak LPS concentration (1 μg/ml) but could not modify the maximal increase of IL-1 release induced by 10 μg/ml of LPS. It did not exert any effect on resting cells. Cetirizine (0.1–10 μg/ml) enhanced PGE2 release by resting human monocytes. Concentrations of 1 and 10 μg/ml enhanced PGE2 release by LPS-stimulated monocytes, and by healthy and inflamed rat macrophages. This effect was concentration-dependent. Our findings point to an anti-inflammatory action of cetirizine via PGE2 release and histamine H2 interactions. Cetirizine did not directly modify IL-1 generation by resting monocytes but the IL-1 production observed after LPS stimulation could promote the mechanisms by which PGE2 is released.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02005756
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  • 10
    Electronic Resource
    Electronic Resource
    Pharmacological mediators of various immunological and non-immunological inflammatory reactions produced in the pleural cavity (1975)
    Springer
    Inflammation research 5 (1975), S. 528-533 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Intrapleural exudates have been produced in rats and guinea-pigs using calcium pyrophosphate, cell mediated immunity, reversed passive Arthus reaction and carrageenan. The intracellular concentration of various pharmacological mediators has been measured at different times during the evolution of these inflammatory responses. These have been correlated with volume of exudate and cellular migration. The significance of these findings has been discussed and the possible application to the search for new anti-inflammatory agents and their use in diagnostic procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972690
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