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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 27 (1955), S. 248-253 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0533
    Keywords: Fibroblast growth factor (FGF) ; Basic FGF ; Angiogenesis ; Brain tumors ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fibroblast growth factor (FGF) is a potent angiogenic factor and a mitogen for a variety of mesoderm-and neuroectoderm-derived cell types (e.g., fibroblasts, endothelial cells, astrocytes, oligodendrocytes). After application of a monospecific polyclonal antiserum, we localized basic FGF on frozen sections of 73 human brain tumors using immunohisto-chemistry. FGF was present in a variable number of tumor cells (16/16 astrocytomas, 5/5 ependymomas, 0/3 benign and 4/7 anaplastic oligodendrogliomas, 11/12 glioblastomas, 11/11 meningiomas, 6/6 neurilemmomas, 0/3 pituitary adenomas, 2/2 choroid plexus papillomas, 0/1 neurocytoma, 2/2 benign fibrous histiocytomas, 2/5 metastatic carcinomas). FGF was detected in vascular cells of 59 tumors and in fibroblasts of connective tissue stroma from all papillomas and metastases. These results tend to indicate FGF involvement in the malignant progression of gliomas due to an autocrine or paracrine action. Histopathological aspects of malignant gliomas (e.g., pseudopalisading or pathological vessels) could be related to FGF activity.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 60 (1982), S. 823-828 
    ISSN: 1432-1440
    Keywords: Diabetes mellitus ; Plasma norepinephrine ; Blood pressure regulation ; Diabetes mellitus ; Plasmanoradrenalin ; Blutdruckregulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Verhalten von Blutdruck, Plus und Plasmanoradrenalin während verschiedener Stimulationsmanöver sympathisch nervöser Aktivität sowie das vaskuläre Reaktionsvermögen auf infundiertes Noradrenalin (50, 100 und 200 ng/kg−1/min−1,t=15 min) wurde bei 17 Diabetikern und 6 gesunden Probanden untersucht. Unterschieden wurden Diabetiker 1) ohne Zeichen autonomer Dysfunktion und ohne periphere Neuropathie (n=6), 2) ohne Zeichen autonomer Dysfunktion jedoch mit schwerer peripherer Neuropathie (n=6) und 3) mit autonomer Dysfunktion, mit (n=3) und ohne (n=2) peripherer Neuropathie. Während eines „Cold pressor tests“ (2 min), mechanischer Hautirritation (10 min) und Orthostase (10 min) zeigten Diabetiker ohne klinische Zeichen autonomer Dysfunktion ein den gesunden Kontrollpersonen vergleichbares Verhalten von Blutdruck, Plus und Plasmanoradrenalin, während Diabetiker mit autonomer Dysfunktion unabhängig vom Bestehen einer peripheren Neuropathie während der Orthostase, nicht jedoch während des „Cold pressor tests“ und mechanischer Hautirritation eine deutlich herabgesetzte Noradrenalinfreisetzung (P〈0.05) aufwiesen. Normalpersonen und Diabetiker ohne autonome Dysfunktion unterschieden sich bezüglich ihres Blutdruckverhaltens während Noradrenalininfusion nicht, während Diabetiker mit autonomer Dysfunktion auf die Verabreichung von exogenem Noradrenalin (200 ng/kg/min) mit einem gegenüber Normalpersonen verstärkten (P〈0.05) Blutdruckanstieg reagierten. Störungen der Noradrenalinfreisetzung und der adrenergen Blutdruckregulation scheinen somit, unabhängig vom Bestehen einer peripheren Neuropathie, nur bei Diabetikern mit klinischen Zeichen autonomer Dysfunktion aufzutreten. Der Nachweis derartiger Störungen gelingt jedoch nur bei Anwendung von Stimuli größerer Intensität wie Orthostase oder Infusion einer hohen Noradrenalindosis.
    Notes: Summary Changes in blood pressure (BP) and plasma norepinephrine (NE) following various stimuli of the sympathetic nervous system were studied in six healthy subjects and in 17 diabetic patients. The latter were subdivided in three groups: (1) six patients with neither peripheral neuropathy nor autonomic dysregulation, (2) six patients with severe peripheral neuropathy without autonomic dysregulation, and (3) five patients with autonomic dysregulation, three of whom suffered also from peripheral neuropathy. The following procedures were performed: (1) cold pressor test (2 min), (2) mechanical irritation of the skin by suction (0.75 kg/cm2, 10 min), (3) orthostasis (10 min), and (4) i.v. infusion of NE (50, 100, 200 ng kg−1 min−1 for 15 min each). Both the stimulated endogenous plasma NE levels and BP response to exogenous NE were the same in normal subjects, in diabetic controls and in diabetics with peripheral neuropathy without autonomic dysregulation. In contrast, diabetics with postural hypotension showed a less pronounced release of NE to standing (P〈0.05), but not to cold pressor test and mechanical skin irritation. Furthermore, they showed increased vasoreactivity to the highest dose (P〈0.05), but not to the lower doses of exogenous NE. Thus NE release and adrenergic BP regulation seem to be altered only in diabetics with clinical signs of autonomic dysregulation. These alterations can only be evaluated when patients are exposed to stimuli of higher intensity, such as orthostasis or infusion of a high NE dose.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1106
    Keywords: Preoptic ; anterior hypothalamic area ; GABA ; Muscimol ; Norepinephrine turnover ; LH ; Prolactin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of intraventricular injections of the highly specific gamma-amino-butyric acid (GABA) agonist muscimol (5 nmol/animal) on blood LH and prolactin levels were measured in ovariectomized (ovx) and in ovx estrogen-progesterone (OEP) primed rats. While the drug stimulated pituitary prolactin release in both experimental groups, pituitary LH release was significantly inhibited in the ovx animals. Muscimol was without any effect on LH levels in ovx-OEP primed rats. Bilateral implantation of tubes containing a muscimol-mannitol mixture into the medial preoptic/ anterior hypothalamic (MPO/AH) area abolished pulsatile LH release whereas blood prolactin values were elevated. The intraventricular injection of GABA (8 μmol) also reduced LH and increased prolactin levels in the blood. Measurements of catecholamine turnover rates in the MPO/AH and in the mediobasal hypothalamus (MBH) yielded reduced preoptic but unchanged hypothalamic norepinephrine (NE) and stimulated hypothalamic dopamine (DA) turnover. In view of the well known stimulatory involvement of the NE system in the mechanism of pulsatile LH release and the inhibitory effect of GABA and its agonist muscimol on pulsatile LH release, it is suggested that GABA inhibits NE release in the MPO/AH by the mechanism of presynaptic inhibition. The observation that muscimol is unable to suppress LH release in vox OEP-primed rats may indicate that those estrogen receptive neurons in the MPO/AH which mediate the negative feedback action of the steroid may use GABA as neurotransmitter and that they are the neurons which inhibit NE release. The inhibitory effect of locally implanted muscimol into the MPO/AH also supports this hypothesis. The facilitatory action of this implanted GABAergic drug on prolactin release points to the involvement of control mechanisms for the regulation of prolactin secretion which reside in the MPO/ AH. The stimulatory effect of intraventricularly injected GABA on hypothalamic DA turnover makes it likely that other than dopaminergic mechanisms are involved in mediating the stimulatory effect of GABA on prolactin release.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Inorganica Chimica Acta 204 (1993), S. 239-246 
    ISSN: 0020-1693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physica A: Statistical Mechanics and its Applications 182 (1992), S. 489-508 
    ISSN: 0378-4371
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Bioenergetics 1142 (1993), S. 59-68 
    ISSN: 0005-2728
    Keywords: Chlorophyll fluorescence induction ; Electron acceptor ; Photoinhibition ; Photosystem II heterogeneity ; Quinone ; Repair cycle
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 129 (1985), S. 18-25 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 57 (1974), S. 901-909 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In the Bardeen–Cooper–Schrieffer theory of superconductivity, electrons form (Cooper) pairs through an interaction mediated by vibrations in the underlying crystal structure. Like lattice vibrations, antiferromagnetic fluctuations can also produce an attractive interaction ...
    Type of Medium: Electronic Resource
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