Electronic Resource
Springer
Bulletin of mathematical biology
52 (1990), S. 535-547
ISSN:
1522-9602
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Mathematics
Notes:
Abstract The variability of the duration of the cell cycle is explained by the phenomenon of sensitive dependence upon initial conditions; as may occur in deterministic non-linear systems. Chaotic dynamics of a system is the result of this sensitive dependence. First a deterministic system is formulated that is equivalent to the Smith-Martin transition probability model of the cell cycle. Next the model is extended to a dynamic process that ranges over the cell generations. A deterministic non-linear relationship between the cycle time of the mother and daughter cell is established. It clarifies the variability of mother-daughter correlation for the different cell types. The model is fitted to two different cell cultures; it shows that the graph of the non-linear relation has the same shape for different cell types.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02462266
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