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  • 1
    Electronic Resource
    Electronic Resource
    Estrogen-inducible breast cancer gene (BCEI/pS2) in colorectal carcinoma after passages in nude mice
    Amsterdam : Elsevier
    Cancer Genetics and Cytogenetics 63 (1992), S. 120 
    Details
    ISSN: 0165-4608
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-4608(92)90422-5
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  • 2
    Electronic Resource
    Electronic Resource
    A genetic-algorithm-based approach to optimization of bioprocesses described by fuzzy rules (1997)
    Springer
    Bioprocess engineering 16 (1997), S. 299-303 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract   A new approach to optimization of bioprocesses described by fuzzy rules is introduced in the paper. It is based on genetic algorithms (GA) and allows to determine optimal values or profiles of control variables and to optimize fuzzy rules (parameters of membership functions). The process can be described by linguistic variables and fuzzy rules. An algorithm and related software was developed. The approach was applied to an industrial antibiotic fermentation. The optimal profile of a physical variable of the preculture was determined which leads to an increasing output product concentration in the main culture of about 5%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004490050326
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Fermentation fault management and on-line state estimation using methods of cluster analysis (1997)
    Springer
    Bioprocess engineering 17 (1997), S. 69-73 
    Details
    ISSN: 0178-515X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The results of the cluster analysis of fermentation data are used for the supervision and on-line state estimation. The results of the classification are presented as the average over all fermentation runs belonging to the class as well as the standard deviation. With the help of the class information the on-line fermentation is associated with the best suiting class. Faults in the data such as spikes or total failure of the sensors are detected as the class information automatically supplies tolerance regions for the measurements. In case of a fault a reliable extrapolation for the time of the fault can be calculated. The approach is implemented in the real-time expert system tool G2 and is applied to data of the carbon dioxide evolution rate (CER) of an industrial antibiotic fermentation process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004490050355
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Model aided design of repeated fed-batch penicillin fermentation (1987)
    Springer
    Bioprocess and biosystems engineering 2 (1987), S. 169-173 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract Structured models of antibiotic fermentation that quantify maturation and aging of product forming biomass are fitted to experimental data. Conditions of superiority of repeated fed batch cultivation are characterized on the basis of a performance criterion that includes penicillin productivity and costs of operation. Emphasis is placed on the relevance of such research to the model aided design of optimal cyclic operation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00387324
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Growth of Escherichia coli in phosphate limited cultures : Measurements and modelling (1979)
    Springer
    Biotechnology letters 1 (1979), S. 377-382 
    Details
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract The batch cultivation ofEscherichia coli limited by inorganic phosphate shows an exponential growth phase followed by a linear phase when the phosphate in the medium is exhausted. Data analysis and modelling of batch cultivation with different initial concentrations of the limiting factor give information about an exchangeable phosphate store, with RNA as the main component, and a non-exchangeable store.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01386703
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Fermentation analysis by clustering (1991)
    Springer
    Bioprocess and biosystems engineering 6 (1991), S. 157-161 
    Details
    ISSN: 1432-0797
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract To supervise, stabilize and optimize antibiotic fermentations in the industrial scale expert systems are presently worked out. For the knowledge acquisition various classifiers are tested using a set of 27 nourseothricin fermentation runs. Two methods are applied: optimal clustering by help of minimum variance criterion and hierarchical clustering by help of dendrograms. The fermentations are classified with respect to the specific material costs as well as the product formation kinetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00369253
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  • 7
    Electronic Resource
    Electronic Resource
    High-cell-density cultivation of microorganisms (1999)
    Springer
    Applied microbiology and biotechnology 51 (1999), S. 422-430 
    Details
    ISSN: 1432-0614
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract High-cell-density cultivation (HCDC) is required to improve microbial biomass and product formation substantially. An overview of HCDC is given for microorganisms including bacteria, archae and eukarya (yeasts). Problems encountered by HCDC and their possible solutions are discussed. Improvements of strains, different types of bioreactors and cultivation strategies for successful HCDC are described. Stirred-tank reactors with and without cell retention, a dialysis-membrane reactor, a gas-lift reactor and a membrane cyclone reactor used for HCDC are outlined. Recently modified traditional feeding strategies and new ones are included, in particular those for unlimited growth to very dense cultures. Emphasis is placed on robust fermentation control because of the growing industrial interest in this field. Therefore, developments in the application of multivariate statistical control, artificial neural networks, fuzzy control and knowledge-based supervision (expert systems) are summarized. Recent advances using Escherichia coli– the pioneer organism for HCDC – are outlined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002530051412
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Computer controlled transient state in a fed batch culture (1980)
    Springer
    Biotechnology letters 2 (1980), S. 315-320 
    Details
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary A controlled shift down of the specific growth rate in a fed batch culture is proposed for microbial product formation processes. The growth kinetics depend on three preset parameters: initial biomass concentration, initial specific growth rate, and the transient constant (time derivative of the specific growth rate). An experimental example is given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00172644
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    On line estimation of a fermenter aeration capacity (kLa) by a computer and dissolved oxygen probe (1985)
    Springer
    Biotechnology letters 7 (1985), S. 267-272 
    Details
    ISSN: 1573-6776
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary An adaptive algorithm for on-line kL-a estimation was developed. The accuracy of on-line kLa estimation was evaluated by means of digital and analog simulation. Simple difference schema developed on the basis of algorithm may be easily applicable in microcomputer-coupled fermentations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01042375
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  • 10
    Electronic Resource
    Electronic Resource
    Instabilities of product formation in a fed-batch culture of Penicillium chrysogenum (1981)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 23 (1981), S. 1563-1572 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: By investigation of a model of benzylpenicillin fermentation it was demonstrated that high fermentation productivity is connected with low stability. The increasing instability is not the result of external disturbances but of peculiarities inherent to the system. The main process variables and the essential parameters were selected by analysis of data obtained from fermentation runs in a pilot plant. By simulation on an analog computer it was shown that the proposed model gives a sufficient description of the kinetic behavior of the fermentation runs. By varying the initial conditions it was possible to obtain two types of fermentation runs. One type is distinguished by a high productivity connected with low initial concentrations of sucrose. An increase of the initial sucrose concentration also causes an increase of productivity. When a certain value of this concentration is exceeded a changeover to a faster growth of biomass takes place combined with the breakdown of productivity. The same phenomenon occurs at a defined initial concentration of sucrose if a disturbance of oxygen transfer rate takes place. Whether the culture stays in the one or in the other state after the disturbance has passed depends on the duration, the strength, and the beginning of the disturbance. In the pilot plant similar behavior can be observed. The sensitivity of fermentation processes to disturbances increases with the increase of productivity.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260230715
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