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  • 1
    Electronic Resource
    Electronic Resource
    Histamine content in human gastric mucosa: Its relation to the pentagastrin-stimulated acid secretion and to selective-gastric vagotomy with drainage (1975)
    Springer
    Inflammation research 5 (1975), S. 427-428 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion No correlation between histamine content of corpus mucosa and maximum response to pentagastrin existed in normal human subjects and in patients suffering from gastric diseases. Normal histamine concentrations were found in duodenal ulcer patients who did not show any reduction in acid output despite complete vagotomy. A relatively low mucosal histamine content was determined in a patient with proven Zollinger-Ellison syndrome. However one year after complete selective-gastric vagotomy the corpus mucosal histamine concentrations were considerably increased. This is the first case in the literature that the histamine content of the human gastric mucosa was altered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972659
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  • 2
    Electronic Resource
    Electronic Resource
    Histamine and peptic ulcer: Influence of sample-taking on the precision and accuracy of fluorometric histamine assay in biopsies of human gastric mucosa (1980)
    Springer
    Inflammation research 10 (1980), S. 175-185 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract From a methodological point of view the relevance of clinical-biochemical trials depends on the answers to mainly four complexes of questions: (1) the reliability of the assays in the clinical situation to be tested, (2) the precision and accuracy of sample-taking, (3) the qualification of the design and the protocols in the clinical part of the trial and (4) the usefulness of the time concepts in the trial concerning biorhythms, seasonal influences, psychological trauma of diagnostic procedures and treatment. In this study mainly the second complex of questions was studied intensely. The precision of the fluorometric histamine assay in biopsy specimens from human gastric mucosa depended on several conditions: Biochemical technique, sample preparation and removal of biopsies from gastric mucosa via endoscopy. The CV% of the whole procedure was about 8-times higher than that of the biochemical technique. In clinical-biochemical studies on the significance of histamine or any other hormone (such as gastrin) in any disease (such as duodenal ulcer) it seems therefore useless to describe the precision of an assay only by the variance of the biochemical technique. Calculation of the histamine content as mean of 3 samples reduced the CV% from 27.2 to 14.9% and should therefore be recommended. The accuracy of the fluorometric histamine assay in biopsy specimens has been tested by several methods recommended by the IFCC and was found to be satisfactory. Conflicing results in the literature concerning the histamine content of human gastric mucosa could be explained on a methodological basis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02024207
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  • 3
    Electronic Resource
    Electronic Resource
    Elevated plasma histamine concentrations in surgery: Causes and clinical significance (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 419-425 
    Details
    ISSN: 1432-1440
    Keywords: Plasma histamine ; operations ; anaesthesia ; plasma substitutes ; acute gastro intestinal ulcers ; Plasmahistaminspiegel ; Operationen ; Narkose ; Blutersatzmittel ; Streßulcus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Histaminkonzentrationen in Plasma, Vollblut und verschiedenen Geweben von Mensch. Affe, Schwein und Hund wurden vor, während und nach Operationen mit fluorometrischen Methoden gemessen. nach intraabdominellen eingriffen wurden bei 6 von 22 Patienten erhöhte Plasmahistaminspiegel noch Stunden nach der Operation gefunden. Als Ursachen der Histaminfreisetzung bei Operationen wurden nachgewiesen: Prämedikation durch Atropin, Anästhesieeinleitung mit intravenös verabreichten Kurznarkotika, Infusion von Plasmasubstituten und Manipulationen am Darm. Akuter Blutverlust war ohne Einfluß auf die Plasmahistaminspiegel. Klinische Symptome und pathophysiologische Reaktionen, wie Tachykardie, arterielle Hypotension, erhöhte Magensekretion und anaphylaktoide Reaktionen konnten auf Histaminfreisetzung unter bestimmten Umständen zurückgeführt werden.
    Notes: Summary Histamine concentrations in plasma, whole blood and various tissues of human subjects, monkeys, pigs and dogs were determined by fluorometric methods before, during and after surgical operations. Following intraabdominal surgery in 6 of 22 patients elevated plasma histamine levels were found several hours after the end of operation. Some of the causes of histamine release in surgery were found to be premedication by atropine, intravenously administered anaesthetics, infusion of plasma substitutes and manipulation on the gut. Acute blood losses were without effect on the plasma histamine levels. Clinical symptoms and pathophysiological reactions, such as tachycardia, hypotension, increased gastric secretion and anaphylactoid reactions could be related to the release of histamine in some circumstances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468582
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  • 4
    Electronic Resource
    Electronic Resource
    Histamine and peptic ulcer: A prospective study of mucosal histamine concentration in duodenal ulcer patients and in control subjects suffering from various gastrointestinal diseases (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 947-956 
    Details
    ISSN: 1432-1440
    Keywords: Histamingehalt ; Magenschleimhaut ; Ulkus duodeni ; Gastrointestinale Erkrankungen ; Histaminfreisetzung ; Histamine content ; Gastric mucosa ; Duodenal ulcer ; Gastrointestinal disease ; Histamine release
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In a prospective study the histamine content of the mucosa of the body of the stomach was measured in 100 patients consisting of control subjects, patients with duodenal ulcer and patients suffering from various gastrointestinal diseases. The histamine content was found to be 43 µg/g in male control subjects (median) while in duodenal ulcer patients levels attained were significantly lower by about 30 per cent. In all the other groups of patients histamine concentrations in gastric mucosa were found to be “normal”. Since in most species it is extremely difficult to alter the mucosal histamine concentration by any form of treatment, the diminished histamine content of the gastric mucosa in patients with duodenal ulcer seems remarkable. Among several possible explanations offered for this finding we think the most likely is that histamine release is increased in duodenal ulcer disease.
    Notes: Zusammenfassung In einer prospektiven Studie wurde der Histamingehalt der Korpusschleimhaut bei 100 Patienten gemessen. Diese Patienten schließen Kontrollpersonen, Ulkus-duodeni-Träger und solche mit verschiedenen gastrointestinalen Erkrankungen ein. Der Histamingehalt betrug 43 µg/g bei Kontrollpersonen und war bei Ulkus-duodeni-Kranken signifikant um 30% erniedrigt. Alle anderen Patientengruppen wiesen „normale“ Histamingehalte in der Magenschleimhaut auf. Da es bei allen Säugerarten mit Ausnahme der Ratte äußerst schwierig ist, den Histamingehalt der Magenschleimhaut durch irgendeine Maßnahme zu verändern, erscheint die Abnahme des Histamingehaltes der Korpusschleimhaut beim Ulkus duodeni besonders bemerkenswert. Unter verschiedenen Hypothesen gilt als wahrscheinlichste eine vermehrte Histaminfreisetzung beim chronischen Ulkus duodeni.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469008
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    Paper (German National Licenses)
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