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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 5 (1981), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 9 (1985), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 10 (1995), S. 15-18 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'examen histologique des hémorroïdes est réalisé en détail dans cette étude; une attention toute particulière a été aux changements muqueux. Ces derniers comportent une distorsion des cryptes avec une hyperplasie du stroma qui ressemble de manière singulière aux changements observés dans le syndrome du prolapsus muqueux. Nous proposons done que le syndrome du prolapsus muqueux devrait inclure les hémorroïdes comme faisant partie de cette entité nosologique.
    Notes: Abstract The histological features of haemorrhoids are detailed in this study with special attention to the mucosal changes. These include significant crypt distortion, wiht stromal hyperplasia which bear a remarkable resemblance to the changes seen in mucosal prolapse syndrome. We propose that the mucosal prolapse syndrome should include haemorrhoids as part of the spectrum.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 12 (1997), S. 342-343 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1262
    Keywords: Key words Fat clearance ; Immunohistochemistry ; Colorectal carcinoma ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Afin d'évaluer la signification de micrométastases en relation avec le taux de survie, les pièces opératoires de 48 patients porteurs d'un cancer colorectal ont été analysées après clearance de la graisse périrectale. Le nombre et la taille des ganglions lymphatiques contenant des métastases et la signification de ces micrométastases en relation avec la survie des patients ont été déterminés. Nous avons trouvé que la majorité des métastases lymphatiques (71.8%) avaient 5 mm ou moins de diamètre et que leur taille n'avait pas d'effet sur la survie. Des colorations immunohistochimiques des ganglions lymphatiques ont révélé que 15 des 25 patients diagnostiqués comme présentant un cancer au stade B de Dukes sur des colorations de routine contenaient en fait des micrométastases et que 86% de celles-ci mesuraient moins de 5 mm de diamètre. La survie de ce sous-groupe a été considérablement plus mauvaise que celle de patients au stade B de Dukes sans micrométastases. Aucun des trois patients à un stade A de Dukes ne présentait de micrométastases. Etant donné que la plupart des métastases et micrométastases surviennent sur des ganglions lymphatiques de 5 mm et moins et que ces dernières peuvent aisément être méconnues lors d'examens de routine, nous proposons que la clearance de la graisse périrectale et une analyse immunohistochimique de routine des cancers au stade de Dukes B améliorent la prédiction de survie des patients opérés d'un cancer colorectal.
    Notes: Abstract To evaluate the significance of micrometastases in relation to survival rate, specimens from 48 colorectal carcinoma patients were analysed after fat clearance. The number and size of the lymph nodes harbouring metastases and the significance of micrometastases for patients' survival were assessed. We found that although the majority of metastatic lymph nodes (71.8%) were 5 mm or less in diameter, their size had no effect on survival. Immunohistochemical staining of lymph nodes revealed that 15 of 25 patients with Dukes' stage B diagnosed by routine staining had micrometastases, 86% of these lymph nodes being less than 5 mm in diameter. The survival rate of this subgroup was found to be considerably poorer than that of Dukes' stage B patients with no micrometastases. None of the three patients with Dukes' stage A carcinoma had micrometastases. Since most of the metastases and micrometastases occur in lymph nodes of 5 mm and less and can be easily missed by routine examination, we suggest that fat clearance and routine immunohistochemical analysis of Dukes' stage B improve the prediction of outcome of colorectal cancer patients.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of colorectal disease 9 (1994), S. 141-148 
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé La gélatinase B (92 kD, matrice métalloprotéinase-9, MMP-9), une enzyme capable de dégrader de nombreux composants du tissu conjonctif a été mise en évidence par immuno-localisation dans des specimens de cancers colo-rectaux (n=40) mais sa distribution entre les divers échantillons était inégale. La mise en évidence de MMP-9 était plus fréquemment observée dans des tumeurs d'un stade avancé et particulièrement sur les berges et en profondeur de ces tumeurs et dans les zones ulcérées. La coloration du MMP-9 a été observée dans des cellules épithéliales transformées, des macrophages et des neutrophiles mais rarement dans des cellules vasculaires ou des cellules du stroma. Au contraire l'enzyme était absente des cellules épithéliales d'une muquese normale. L'immuno-coloration du collagène type IV, le composant structurel majeur des membranes basales, montrent une déplétion générale ou une perte de ces structures à la fois dans les tumeurs et dans les marges de celles-ci. La localisation par immuno-histochimie à la fois de MMP-9 et du type IV du collagène démontre que l'expression du MMP-9 dans certains sites tumoraux est souvent en relation inverse à la distribution du collagène de type IV. L'expression de MMP-9 était plus prononcée sur les berges d'une tumeur invasive et dans des microfoyers tumouraux lorsque les cellules tumorales étaient à proximité immédiate de cellules inflammatoires. Ces observations soutiennent le concept que des activités protéolytiques et collagénolytiques localisées contribuent à l'extansion des tumeurs colo-rectales.
    Notes: Abstract Gelatinase B (92 kD matrix metalloproteinase-9, MMP-9), an enzyme capable of degrading several connective tissue components, was demonstrated by immunolocalization in all specimens of colorectal carcinoma (n=40), but its distribution between specimens was variable. MMP-9 expression was more frequently observed in advanced tumour stages and was especially prevalent at the side and deep margins of the tumours, and ulceration sites. MMP-9 staining was observed for transformed epithelial cells, macrophages and neutrophils, but seldom for vascular or stromal cells. By contrast, the enzyme was absent from epithelial cells of normal mucosal tissue. Immunostaining of type IV collagen, the major structural component of basement membranes, revealed a general depletion or loss of these structures both within the tumours and at the tumour margins. Dual immunolocalization of MMP-9 and type IV collagen demonstrated that MMP-9 expression at specific sites in the tumour was often inversely related to the distribution of type IV collagen MMP-9 expression was most pronounced at the invasive tumour margins and in microfoci where tumour cells were in close proximity to inflammatory cells. Such observations support the concept that localized proteolytic and collagenolytic activities contribute to the invasive properties of colorectal tumours.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2218
    Keywords: Key words: Consensus development conference — Diverticulitis — Contrast enema — Hartmann resection — Laparoscopic colectomy — Intraabdominal infections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: With the aim of resolving the current controversy over the diagnosis and treatment of diverticular disease, this consensus development conference set out to summarize the actual state of the art. Methods: A multidisciplinary panel of international experts (n= 16) was selected to take part in the consensus process. Prior to the conference, all experts were asked to answer a series of questions on diverticular disease. The consensus statement compiled out of these evaluations was modified during a joint meeting of the panel members, then presented for discussion in a public session, and finally revised by the expert panel. The finalized statement was mailed to all panel members for approval (Delphi method). Results: Asymptomatic diverticulosis, diverticular disease (with actual or recurrent symptoms), and complicated diverticular disease were defined separately. No agreement was reached on whether barium enema or colonoscopy is the better choice as an initial diagnostic tool in uncomplicated cases. In complicated cases, computed tomography is recommended for diagnosis. After two attacks of diverticular disease, elective resection should be considered. For patients in whom a concomitant carcinoma cannot be excluded and those with chronic complications (fistula, stenosis, or bleeding) surgery is also indicated. Laparoscopic sigmoid colectomy is recommended only for uncomplicated and, after percutaneous drainage of abscesses, Hinchey stage I and II cases. Conclusions: Laparoscopic surgery has already begun to influence the management of diverticular disease, but the randomized controlled trials needed to support therapy decisions are largely missing.
    Type of Medium: Electronic Resource
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