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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 5 (1926), S. 1569-1569 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 6 (1927), S. 312-313 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Lung 64 (1926), S. 199-202 
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 90 (1920), S. 22-36 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 110 (1929), S. 355-381 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung 1. Ebenso wie die moderne Fermentforschung einen prinzipiellen Unterschied zwischen Ekto- und Endoenzymen (Ferment und Enzym) nicht mehr anerkennt, dürfte bei fortschreitender Kenntnis der bakteriellen Toxine — die Unterscheidung zwischen Ekto- und Endotoxinen an Bedeutung verlieren. 2. Es wird ein Züchtungsverfahren beschrieben, welches durch fraktionierten Zuckerzusatz und durch gleichzeitige dauernde Aufrechterhaltung einer alkalischen Reaktion den Choleravibrionen eine intensive Ausnutzung der Kohlehydrate ermöglicht, ohne daß eine vorzeitige Selbstvergiftung der Kultur eintritt. 3. Die Wirkung des Choleragiftes auf das Meerschweinchen (bei intraperitonealer Injektion) verläuft unter dem Bilde eines akuten Anfalles (initialer Temperatursturz), dem ein stationäres Stadium folgt, in welchem das Tier unter dem sekundären Einfluß irreversibler Schädigungen zugrunde geht. Die Bildung des Giftes setzt ein, sobald in der Kultur eine maximale Keimzahl erreicht ist; sie erfolgt also zeitlich hauptsächlich in der Absterbephase. Das labile Choleratoxin kann durch Herstellung eines wirksamen Trockenpräparates in eine beständigere, dosierbare Form überführt werden. 4. Das Choleragift ist durch Pergamentmembranen nicht dialysierbar. Durch Dialyse kann ein erheblicher Teil der Ballaststoffe entfernt und so eine Anreicherung des Giftes erzielt werden. 5. Durch Immunisierung von Ziege und Pferd wird ein wirksames antitoxisches Serum gewonnen. 6. Der Nachweis von Gift gelingt in erster Linie bei solchen Stämmen, welche bei der Züchtung auf Hammelblutagarplatten eine deutliche Hämolyse hervorrufen. Ein Zusammenhang zwischen der hämolysierenden Fähigkeit und der toxischen Funktion wird dadurch wahrscheinlich gemacht, daß diejenige Serummenge, welche eine einfach tödliche Giftdosis absättigt, gerade auch den mit dieser Giftmenge verknüpften hämolytischen Effekt neutralisiert.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 98 (1922), S. 569-577 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 46 (1995), S. 421-424 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Laser-Doppler-Flux ; Kutane Mikrozirkulation ; Morphaea ; Zirkumskripte Sklerodermie ; Therapiekontrolle ; Key words Laser-Doppler flux ; Microcirculation of the skin ; Morphoea ; Circumscribed scleroderma ; Control of therapy results
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A 38-year-old male patient presented with circumscribed scleroderma (10×12 cm) in the left pectoral area. Hyperaemia of the skin in the area of the lilac ring (morphoea) was quantified by means of Laser-Doppler flux (LDF). At the lilac border of the morphoea LDF was increased to 420% of the reference value recorded for the unaffected skin of the contralateral side. Immediately after 13 days of antibiotic therapy (3×10 Mega penicillin G per day, i.v.) LDF normalized, though clinical changes were hardly apparent at this stage. By 6 months later, LDF was still in the normal range, and clinical signs, such as induration and hyperaemic redness, had also significantly improved. LDF measurements allow assessment of the therapeutic response to antibiotic therapy at a very early stage while the clinical situation is still unchanged.
    Notes: Zusammenfassung Wir berichten über einen 38jährigen Patienten mit zirkumskripter Sklerodermie (CS) und einem linkspektoralen Morphaea-Herd. Der Rückgang einer entzündlich gesteigerten Mehrdurchblutung im Areal des Lilac-Rings wurde durch wiederholte Messungen des Laser-Doppler-Flux (LDF) unter Therapie objektiviert. Unmittelbar vor Therapiebeginn sowie am letzten Behandlungstag und nach weiteren 6 Monaten wurde der Laser-Doppler-Flux an denselben Hautarealen im entzündlichen Randbereich, im Zentrum des Morphaea-Herdes sowie im Gesunden rechtspektoral bestimmt. Vor Antibiose fand sich im Lilac-Ring eine auf 420% – im Vergleich zum gesunden rechtspektoralen Referenzareal – gesteigerte Fluxmotion. Nach 13tägiger Therapie mit Penicillin G (3×10 Mega i.v.d) kam es zu einer Normalisierung der pathologisch erhöhten Meßwerte, während klinische Veränderungen zu diesem Zeitpunkt kaum erkennbar waren. Erst 6 Monate später – die LDF-Werte waren immer noch im Bereich der Vergleichswerte gesunder Haut – war klinisch eine deutliche Rückläufigkeit von Induration und Erythem sichtbar. Mit Laser-Doppler-Flux-Messungen kann frühzeitig, bevor klinisch eine Verbesserung diagnostiziert werden kann, das therapeutische Ansprechen nachgewiesen werden.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To study the influence of compression on the haemodynamics o the deep venous system in pregnancy.Design A prospective, observational studySetting The phlebological unit of the department of dermatology at a university hospital.Population Fifteen pregnant women with no previous signs of chronic venous insufficiency.Methods Parameters of the venous pump function were assessed by strain-gauge plethysmography. Blood flow velocity, flow volume and vessel diameter in the superficial femoral vein were measured by duplex sonography. All examinations were performed with and without applied compression stockings (25–32 mmHg) at two different stages of gestation and after delivery. In addition, subjective symptoms were graded.Results Venous pump function improved and refilling time lengthened significantly when compression was used during gestation and postnatally. Duplex sonography showed an increase in blood flow velocity and flow volume in the superficial femoral vein with applied compression; the vessel diameter increased slightly. Subjective symptoms of the leg, graded on an arbitrary scale, were reduced by regular compression therapy.Conclusion Our results indicate that compression improves the clinical symptoms of venous congestion and the venous haemodynamics of the legs during pregnancy and in the postpartum period. Thus, the regular use of compression during pregnancy and the puerperium may reduce the incidence of thromboembolic events.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Inc
    The @journal of eukaryotic microbiology 52 (2005), S. 0 
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Bacteria belonging to the genus Polynucleobacter were previously described as endosymbionts inhabiting the cytoplasm of freshwater ciliates of the genus Euplotes having a 9 type I cirrus pattern. They were all found to be necessary for the division process of their hosts. Here, we report the finding of a Polynucleobacter bacterium as symbiont of E. harpa, a brackish species with ten frontoventral cirri. Identity of the symbionts was unambiguously determined by morphological description and by 16S rRNA gene sequence characterization. Furthermore, antibiotic treatments confirmed that these bacteria play the same functional role of the other Polynucleobacter symbionts; aposymbiotic E. harpa ceases to divide and eventually die. Phylogenetic analyses based on 18S rRNA gene show that Euplotes species harboring Polynucleobacter symbionts, included E. harpa, steadily cluster together. In order to clear whether this symbiosis was established as a single evolutionary event by a common ancestor of the ciliate hosts, or by multiple acquisition of different bacteria by the different Euplotes species, comparative phylogenetic analyses were performed within the so-called Polynucleobacter-cluster, comprising bacterial symbionts as well as strictly related free-living bacteria. Due to a high degree of conservation of 16S rRNA gene sequences within this group, phylogenetic trees based on this gene did not resolve the matter. Surprisingly, even the characterization and the analysis of the 16-23S ITS sequences, usually exhibiting faster evolutionary rates, revealed a high similarity (〉98%), thus hindering a stable and clear phylogenetic reconstruction. Data obtained cannot at present definitively confirm or reject any hypothesis on the origin of this symbiosis, revealing, at the same time, that we are dealing with a relatively young symbiotic system. As shown by the close phylogenetic relationship between free-living and symbiotic Polynucleobacter, this is an ideal model for studying development and adaptation to symbiotic lifestyle.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology ecology 35 (2001), S. 0 
    ISSN: 1574-6941
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Predation by bacterivorous protists in aquatic habitats can influence the morphological structure, taxonomic composition and physiological status of bacterial communities. The protistan grazing can result in bacterial responses at the community and the species level. At the community level, grazing-induced morphological shifts have been observed, which were directed towards either larger or smaller bacterial sizes or in both directions. Morphological changes have been accompanied by changes in taxonomic community structure and bacterial activity. Responses at the species level vary from species to species. Some taxa have shown a pronounced morphological plasticity and demonstrated complete or partial shifts in size distribution to larger growth forms (filaments, microcolonies). However, other taxa with weak plasticity have shown no ability to reduce grazing mortality through changes in size. The impact of protistan grazing on bacterial communities is based on the complex interplay of several parameters. These include grazing selectivity (by size and other features), differences in sensitivity of bacterial species to grazing, differences in responses of single bacterial populations to grazing (size and physiology), as well as the direct and indirect influence of grazing on bacterial growth conditions (substrate supply) and bacterial competition (elimination of competitors).
    Type of Medium: Electronic Resource
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