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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Analytica Chimica Acta 113 (1980), S. 139-147 
    ISSN: 0003-2670
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 6 (2001), S. 0 
    ISSN: 1440-1797
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Recent clinical trials indicate that non-immunological mechanisms (e.g., glomerular hypertension or hypertrophy) may play a crucial role in the progression of patients with IgA nephropathy. Since the long-term renal histological changes in an individual patient with IgA nephropathy are not well elucidated, we assessed the serial renal biopsy specimens from nine patients with IgA nephropathy (five males, four females) where serial biopsies were performed in an interval of more than 10 years (mean 12.8; range 10–20). Histological parameters (i.e. percentage of global sclerosis (GS), tubulo-interstitial lesion (TI), patients (Pt) with cellular crescent (CC) or arteriolosclerosis (AS), mean glomerular area (MGA) and number of glomeruli per renal cortical area (glomerular density, GD)), were compared between the both specimens (〈link href="#t1"〉Table 1).〈tabular xml:id="t1"〉〈table frame="topbot"〉〈tgroup cols="11" align="left"〉〈colspec colnum="1" colname="col1" align="left"/〉〈colspec colnum="2" colname="col2" align="center"/〉〈colspec colnum="3" colname="col3" align="char" char="."/〉〈colspec colnum="4" colname="col4" align="char" char="[plusmn]"/〉〈colspec colnum="5" colname="col5" align="char" char="[plusmn]"/〉〈colspec colnum="6" colname="col6" align="center"/〉〈colspec colnum="7" colname="col7" align="char" char="."/〉〈colspec colnum="8" colname="col8" align="char" char="[plusmn]"/〉〈colspec colnum="9" colname="col9" align="char" char="[plusmn]"/〉〈colspec colnum="10" colname="col10" align="char" char="."/〉〈colspec colnum="11" colname="col11" align="char" char="[plusmn]"/〉〈thead valign="bottom"〉〈row rowsep="1"〉Renal
biopsyAge
(year)〈entry align="center"〉Pt with HT
(%)〈entry align="center"〉UprV
(g/day)〈entry align="center"〉Ccr
(mL/min)GS
(%)〈entry align="center"〉Pt with CC
(%)〈entry align="center"〉MGA
(× 103μmm)〈entry align="center"〉GD
(/mm2)〈entry align="center"〉Pt with AS
(%)〈entry align="center"〉TI
(%)〈tbody valign="top"〉First25 ± 8220.6 ± 0.388 ± 1710 ± 117815 ± 6.03.9 ± 2.01113 ± 8Second38 ± 878〈link href="#tn1"〉*1.3 ± 0.6〈link href="#tn1"〉*55 ± 21〈link href="#tn1"〉*25 ± 2311〈link href="#tn1"〉*22 ± 8.4〈link href="#tn1"〉*2.0 ± 0.8〈link href="#tn1"〉*89〈link href="#tn1"〉*34 ± 16〈link href="#tn1"〉*〈note xml:id="t1_note11" numbered="no"〉Mean ± SD, *P 〈 0.05 vs first biopsyAll patients had a slowly progressive course between the first and second biopsies as evidenced by the significant difference in the percentage of hypertension (HT), urinary protein excretion (UprV) and creatinine clearance (Ccr). Histological analysis of serial biopsy specimens revealed that the degrees of AS and TI were significantly enhanced at second biopsy, while acute glomerular lesions such as CC were remarkably diminished. Of note, a marked increase in MGA as well as a significant reduction in GD were observed during over 10 years. Moreover, at second biopsy, the values for MGA from individual patients negatively correlated with those for GD (r = 0.77, P 〈 0.01) and Ccr (r = 0.65, P 〈 0.01). These data indicate that patients with IgA nephropathy undergo glomerular hypertrophy subsequent to the reduction in nephron mass in the long-term and glomerular hypertrophy may play an important role in the slow progression of patients with IgA nephropathy.
    Type of Medium: Electronic Resource
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