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  • 1
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 98 (1976), S. 3849-3852 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 255-257 (Sept. 1997), p. 536-538 
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1279-8517
    Keywords: Anatomy ; Retroperitoneal anatomy ; Extraperitoneal approach ; Anterior lumbar interbody fusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les abords antérieurs du rachis lombaire sont pratiqués pour l'obtention d'une fusion dans les cas de rachis dégénératif mais également pour combler des pertes de substance osseuse ou des vides discaux après les réductions de fracture. Nous présentons un abord antérieur extra-péritonéal applicable pour n'importe lequel des niveaux discaux et vertébraux de T12 à S1. L'étude anatomique basée sur 25 cadavres met en évidence les principes de la dissection rétropéritonéale pour une mobilisaion facile du rein et du bloc duodéno-pancréatique et un abord direct antéro-latéral gauche du rachis. Nous avons établi une description précise des veines lombaires et des anastomoses entre la veine rénale gauche et le système hémi-azygos dans l'optique de définir les différents facteurs topographiques et anatomiques indispensables à connaître pour un abord simple sécurisé et reproductible, et pour l'introduction de cages ou de greffes intersomatiques. Indépendamment du niveau à atteindre et des antécédents de chirurgie intra-péritonéale préalable, l'abord du rachis lombaire par cette technique ne pose pas de problème concernant le rein, l'uretère, la rate, le plexus hypogastrique et l'ensemble duodéno-pancréatique. Pour ce qui concerne la durée opératoire, le saignement et les possibilités d'avivement et de greffe, cette technique semble contrebalancer sérieusement les difficultés et la technologie complexe des abords endoscopiques. L'étude clinique rapporte nos 42 premiers cas de pathologie traumatique et dégénérative. Evitant le risque neurologique ou hémorragique inhérent aux techniques classiques de fusion intersomatique lombaire par voie postérieure, cet abord peut être considéré comme une alternative raisonnable et efficace. Cette technique pourrait être utilisée dans le futur proche pour l'insertion “mini-invasive” des prothèses discales.
    Notes: Summary Anterior lumbar spine approaches may be indicated for fusion in degenerative lumbar spine disorders or to fill discal and bone gaps after fracture reduction. We present an anterior extraperitoneal approach applicable to any discal and vertebral levels from T12 to S1. The anatomic study, based on 25 cadavers, highlights retroperitoneal dissection principles for easy kidney and duodenopancreatic mobilisation and direct left anterior access to the entire lumbar spine. We established a precise description of the lumbar veins and the anastomoses between the left renal vein and hemiazygos system, in order to define different topographic and anatomic factors related to safe and easily reproducible approaches for cage or graft implementation. Independent of the level and previous intraperitoneal surgery, lumbar spine access with this approach safeguards the kidney, ureter, spleen, hypogastric plexus and duodenopancreatic system. Regarding operating time, bloodloss and possibilities for freshening and grafting, this technique seems an effective counterbalance to the difficulties and complex technology of endoscopic approaches. The clinical study includes our first 42 cases in traumatic and degenerative lesions. Avoiding the neurologic or hemorrhagic risk inherent in classical posterior lumbar interbody fusion (PLIF) techniques, it can be considered as a reasonable and valid alternative. This technique could be used in the near future for mini invasive discal prosthesis insertion.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1279-8517
    Keywords: Hip ; Pelvis ; Osteotomy ; Acetabulum ; Dysplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pelvic osteotomies were developed to increase or restructure the acetabular surface. Periacetabular osteotomies are considered the most difficult from the technical point of view and necessitate sufficient residual cartilaginous surface. Juxta-acetabular osteotomies avoid major disorganization of the pelvic framework and allow easier reorientation of the acetabulum. The authors present a technical variant that preserves the entire posterior column, as in the Ganz osteotomy. The effects on the vascularisation of the periacetabular region are strictly the same and there is no necrosis of the subchondral bone. This osteotomy is easier to perform, because of a single positioning associating two simultaneous approaches. The osteotomies are rectilinear and easy to check peroperatively by fluoroscopy thanks to this positioning. Another valuable aspect of this double approach consists of very easy correction of “automatic” unwanted retroversion due to the lowering of the acetabular roof. This unintended displacement is rarely reported in the literature, despite its anatomic evidence in 3-dimensional CT-scan reconstructions for pre- and peroperative evaluation.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1279-8517
    Keywords: Hip ; Pelvis ; Osteotomy ; Acetabulum ; Dysplasia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les ostéotomies pelviennes ont été développées pour agrandir l'acétabulum ou le ré-orienter. Parmi celles-ci, les ostéotomies péri-acétabulaires sont réputées difficiles sur le plan technique et nécessitent un capital cartilagineux résiduel suffisant. Les ostéotomies juxta-acétabulaires évitent une désorganisation importante de l'anneau pelvien et donnent une plus grande facilité de ré-orientation de l'acétabulum. Les auteurs présentent une variante technique conservant la colonne postérieure de l'acétabulum comme l'ostéotomie de Ganz. L'ostéotomie est de réalisation plus simple grâce à une seule installation à l'aide de deux abords simultanés. Les traits d'ostéotomie sont rectilignes et contrôlables en permanence par amplificateur de brillance grâce à l'installation. Les conséquences sur la vascularisation de la région péri-acétabulaire sont strictement identiques aux ostéotomies classiques et n'ont jamais entraîné une nécrose osseuse de l'os sous-chondral dans l'expérience clinique des auteurs. Un autre intérêt essentiel du double abord est la correction facile de la rétroversion automatique associée à l'abaissement de l'acétabulum. Ce déplacement parasite, peu rapporté dans la littérature, est pourtant facile à démontrer anatomiquement ou grâce aux reconstructions tri-dimensionnelles de simulation pré et per-opératoire.
    Notes: Summary Pelvic osteotomies were developed to increase or restructure the acetabular surface. Periacetabular osteotomies are considered the most difficult from the technical point of view and necessitate sufficient residual cartilaginous surface. Juxta-acetabular osteotomies avoid major disorganization of the pelvic framework and allow easier reorientation of the acetabulum. The authors present a technical variant that preserves the entire posterior column, as in the Ganz osteotomy. The effects on the vascularisation of the periacetabular region are strictly the same and there is no necrosis of the subchondral bone. This osteotomy is easier to perform, because of a single positioning associating two simultaneous approaches. The osteotomies are rectilinear and easy to check peroperatively by fluoroscopy thanks to this positioning. Another valuable aspect of this double approach consists of very easy correction of “automatic” unwanted retroversion due to the lowering of the acetabular roof. This unintended displacement is rarely reported in the literature, despite its anatomic evidence in 3-dimensional CT-scan reconstructions for pre-and peroperative evaluation.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1279-8517
    Keywords: Anatomy ; Retroperitoneal anatomy ; Extraperitoneal approach ; Anterior lumbar interbody fusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Anterior lumbar spine approaches may be indicated for fusion in degenerative lumbar spine disorders or to fill discal and bone gaps after fracture reduction. We present an anterior extraperitoneal approach applicable to any discal and vertebral levels from T12 to S1. The anatomic study, based on 25 cadavers, highlights retroperitoneal dissection principles for easy kidney and duodenopancreatic mobilisation and direct left anterior access to the entire lumbar spine. We established a precise description of the lumbar veins and the anastomoses between the left renal vein and hemiazygos system, in order to define different topographic and anatomic factors related to safe and easily reproducible approaches for cage or graft implementation. Independent of the level and previous intraperitoneal surgery, lumbar spine access with this approach safeguards the kidney, ureter, spleen, hypogastric plexus and duodenopancreatic system. Regarding operating time, blood-loss and possibilities for freshening and grafting, this technique seems an effective counterbalance to the difficulties and complex technology of endoscopic approaches. The clinical study includes our first 42 cases in traumatic and degenerative lesions. Avoiding the neurologic or hemorrhagic risk inherent in classical posterior lumbar interbody fusion (PLIF) techniques, it can be considered as a reasonable and valid alternative. This technique could be used in the near future for mini invasive discal prosthesis insertion.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This paper presents a method for the determination of histamine using an internal standard of14C-labelled histamine, which together with an unknown sample of unlabelled histamine is dansylated with3H-labelled dansyl chloride. The products of this dansylation are then separated on thin-layer-chromatographic plates coated with micropolyamide. The spot of dansylhistamine is scraped off and the content of histamine in the unknown sample is calculated from the3H/14C-ratio in the spot.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0428
    Keywords: Pancreatic islets ; glucose metabolism ; diacylglycerol ; diacylglycerol lipase inhibitor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of interference with diacylglycerol metabolism was investigated in pancreatic mouse islets. In the presence of the diacylglycerol lipase inhibitor RHC 80267, glucose-induced insulin secretion was reduced 50–60%; whereas carbacholin-induced insulin secretion was unaffected. Addition of the diacylglycerol kinase inhibitor R 59022 did not change glucose-stimulated insulin secretion but abolished the inhibition seen in the presence of RHC 80267. RHC 80267 increased islet glucose utilisation, measured as formation of tritiated water from 5-[3H]-glucose, 3-fold but did not affect glucose oxidation to CO2, lactate production or islet ATP levels. Glucose utilisation in leucocytes and hepatocytes was not increased by addition of RHC 80267. Islet lipid production from glucose was augmented 4-fold in the presence of RHC 80267 but only accounted for about 5% of the increase in glucose utilisation. The activity of adenylate cyclase and phosphoinositide-specific phospholipase C was unaffected by RHC 80267. Concentrations of RHC 80267 below 35 μmol/l did not alter the activity of phospholipase A2; whereas higher concentrations of the drug inhibited phospholipase A2 activity approx 25%. The data support the hypothesis that production of arachidonic acid from diacylglycerol may be involved in regulation of insulin secretion.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; glycolipids ; sulphatide ; islets of Langerhans ; kidney ; peripheral nerves ; eye ; ovary ; thin-layer chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sulphatide has been found in rat islets of Langerhans and anti-sulphatide antibodies have been demonstrated in patients with insulin-dependent diabetes mellitus. Using a specific monoclonal antibody, Sulph I, directed against sulphatide, we investigated the in situ distribution of this glycolipid immunohistochemically; furthermore, the sulphatide concentration was determined in several organs and cells by thin-layer chromatography. The islets of Langerhans in all species examined, mouse, rat, pig, and monkey were intensively stained but exocrine tissue remained unlabelled. The sulphatide concentration in human islets was 150±46 pmol/100 islets. The only glycolipid-antigen detected was sulphatide. Regarding other tissues, sulphatide was found to be located in distal tubules in the kidney, peripheral nerves, distinct scattered spot-like structures in the choreoid layer of the eye, the ovum, and peripheral granulocytes. Sulph I injection in mice showed homing to kidney tubules. Lung, heart, liver, adrenal, spleen, lymph node and thymus were not stained by Sulph I. Thus, the distribution of sulphatide shows an association with organs known to be affected in diabetes, either initially or in late complications.
    Type of Medium: Electronic Resource
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