Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    The role of tissue mast cells in polyacrylamide gel-induced inflammation in mice (1998)
    Springer
    Inflammation research 47 (1998), S. 104-108 
    Details
    ISSN: 1420-908X
    Keywords: Key words: Mast cells — TNFα— Neutrophils — Leukotrienes — Prostaglandins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: In the present study, we investigated the role of mast cells in a model of polyacrylamide gel (PAG)-induced inflammation in mice.¶Subjects: Balb/c mice and two strains of mast cell deficient mice (WBB6F1/J-W/Wv, WCB6F1/J-S1/S1d).¶Treatment: Various quantities of polyacrylamide gel (Bio-Gel P4) were injected subcutaneously in the backs of mice.¶Methods: Five hours after the injection of PAG the animals were euthanized, the injection sites lavaged and levels of LTB4, PGE2, TNFα and cells were determined.¶Results: Subcutaneous injection of PAG caused a time-dependent response characterized by the accumulation of inflammatory cells peaking at 10 h and the formation of LTB4, PGE2 and TNFα, peaking at 5 h. PAG injection into W/Wv or SL/SLd mice (mice lacking mast cells) resulted in an attenuated response, i.e. LTB4 levels were reduced by 60% and minimal cell influx was seen. The lack of mast cells caused about a 30% reduction in the levels of TNFα found.¶Conclusions: These data suggest that mast cells play a prominent role in the PMN influx, TNFα production and eicosanoid formation in the PAG-induced inflammatory response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050292
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Heavy metal contamination and physiological variability in the Brazilian mangrove crabs Ucides cordatus and Callinectes danae (Crustacea: Decapoda) (2000)
    Springer
    Marine biology 137 (2000), S. 691-703 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Physiological studies were made on the crabs Ucides cordatus (L.) and Callinectes danae sampled from populations living in “polluted” mangroves on the southeast littoral of Brazil. Analysis of Cu, Cd, Zn, and Fe of sediments and crab tissues showed interspecific differences in tissue concentrations, and significantly higher levels of Cu, Cd, and Zn in “polluted” populations compared to “unpolluted” crabs living in uncontaminated mangrove in the same geographical area. Individuals of both species from the polluted site showed significantly greater capacities for regulating blood osmotic concentrations at low salinity (9‰). However, U. cordatus showed a reduced hypo-regulatory ability in 34‰S. Differences in ionoregulation were also seen. “Polluted”C. danae showed significantly higher Na/ K-ATPase levels in posterior gills compared to “unpolluted” crabs. Oxygen consumption rates (M˙ O2) were elevated in U. cordatus, but depressed in C. danae from the “polluted” population. Individuals of both species from this site showed significantly lower O:N ratios, mainly because of an increased net efflux of ammonia. Adenylate energy charge (AEC) values of muscle and hepatopancreas in “unpolluted” and “polluted” populations of both species were not significantly different. These physiological differences are discussed in relation to the known acute physiological and metabolic effects of heavy metals in crustaceans, and interpretated in the light of possible adaptive changes following long-term exposure to contamination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002270000382
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Aspects of sodium regulation in a brackish-water and a marine species of the isopod genus Sphaeroma (1972)
    Springer
    Marine biology 12 (1972), S. 18-27 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Sodium and chloride concentrations of the haemolymph were determined in Sphaeroma rugicauda Leach and S. serratum Fabricius acclimatized to a range of salinities. Sodium loss and uptake (using 22Na) were measured in salinities below 1.1‰ for S. rugicauda and 7.2‰ for S. serratum. Potential differences between haemolymph and medium indicate active uptake of both ions in certain salinities. The active-uptake component of total sodium-influx was found to be related non-linearly to the sodium concentration of the medium. Curves of $$\dot 6$$ were fitted to the activeuptake data. Km values indicate that, in S. rugicauda, the sodium uptake system has a greater affinity for sodium than in S. serratum. These findings are discussed in relation to the distribution of each species.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00347426
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Water Pollution Legislation and Administration. (1951)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 43 (1951), S. 2678-2686 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50504a021
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Solubility of Melamine in Water (1943)
    s.l. : American Chemical Society
    Industrial & engineering chemistry 35 (1943), S. 137-138 
    Details
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ie50398a003
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Fatty-acid metabolism in oral mucosal epithelium of the hamster (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 13 (1984), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Little is known about the role of lipid metabolism in oral mucosal epithelia, although lipids probably play significant roles in the barrier function and in the production of energy for the various epithelial biosynthetic activities. The metabolic fate of exogenously added 14C-labelled oleic acid in pure epithelial sheets from hamster cheek-pouch has been investigated. Significant amounts of the label from the tatty acid were found in phosphatidyl choline, sphingomyelin and triglyceride fractions. Lesser amounts were found in cholesterol, cholesterol ester, ceramide and phosphatidyl ethanolamine. Estimations of the amount of ATP produced by both glycolysis and by fatty-acid β-oxidation indicated that the 2 activities were essentially equal, which is in contrast to that reported for the epidermis. The results suggest that the oral mucosal epithelium, like the epidermis, is an active lipid-metabolizing tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1984.tb01439.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Effects of repeated treatment of hamster ear epidermis and cheek-pouch mucosa with 12-0-tetradecanoylphorbol-13-acetate (1983)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 12 (1983), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effects of repeated stimulation of hamster oral mucosa and epidermis with 12-0-tetradecanoylphorbol-13-acetate (TPA), were examined using in vitro assays of glycolysis and amino acid incorporation. The response of control and hyperplastic tissues to epinephrine and cAMP, and their rates of incorporation of histidine and leucine, were also examined. Repeated treatment with TPA in the concentration range of 1 × 10−8 to 1 × 10−5 M resulted in increased rates of glycolysis, amino acid incorporation and mitosis in both tissues. During the induction of hyperplasia, a loss of the normal epithelial response to epinephrine was observed at Day 8, suggesting re-establishment of mechanisms controlling homeostasis. Application of TPA resulted in a reduction in the amount of histidine incorporated relative to leucine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1983.tb00347.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Effects of the anti-inflammatory agents indomethacin, metiamide and acetylsalicylic acid on the induction of hyperplasia in hamster cheek-pouch epithelium and ear epidermis (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 13 (1984), S. 0 
    Details
    ISSN: 1600-0714
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Previous studies have shown that agents such as indomethacin and hydrocortisone act to reduce the level of epidermal hyperplasia produced by various chemicals, but little information is available about the effects of such anti-inflammatory agents on the induction of hyperplasia in oral mucosa. Hamster cheek-pouch epithelium and ear epidermis were treated with indomethacin, metiamide and acetylsalicylic acid prior to treatment with turpentine, podophyllin or TPA. The levels of hyperplasia induced were monitored by rates of epithelial glycolysis, protein synthesis and mitosis. The response of the metabolic assays to epinephrine was also examined. Alone, turpentine, podophyllin and TPA each caused a 3–5 fold increase in the metabolic assays and loss of the normal tissue response to epinephrine. Tissues pretreated with indomethacin showed significant reductions in the levels of hyperplasia produced and they retained a normal response to epinephrine. No reduction in hyperplasia was observed following pretreatment with acetylsalicylic acid, an alternative inhibitor of prostaglandin synthesis or with metiamide, a histamine blocker. The results indicate that the production of epithelial hyperplasia by turpentine, podophyllin and TPA can be inhibited by indomethacin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0714.1984.tb01409.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Phospholipase A2 (PLA2) activity in bovine pulmonary artery endothelial cells (1991)
    Springer
    Inflammation research 34 (1991), S. 113-116 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have investigated the role of recombinant human interleukin-1β (rIL-1β) and recombinant human tumor necrosis factorα (rTNF-α) on PLA2 activity, protein synthesis and eicosanoid production in bovine pulmonary artery endothelial cells. Cellular PLA2 activity increased 4-fold and production of PGE2 increased 3-fold at 1–2 hrs in the presence of 10 units/ml rIL-1β. PLA2 activity increased 3-fold at 30 min and PGE2 production increased 2-fold with 5×10−9 M rTNF-α. The data show that endothelial cells respond more rapidly to rIL-1β (2–6 hr) and rTNF-α (30 min) than do chondrocytes and synovial cells (6–16 hrs), suggesting endothelial cells may play a primary role in initiating the inflammatory response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01993253
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Topical anti-inflammatory activity of DuP 654, a 2-substituted 1-naphthol (1989)
    Springer
    Inflammation research 27 (1989), S. 297-299 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recent work suggests that one of the common biochemical characteristics of skin inflammatory diseases such as psoriasis is altered arachidonic acid metabolism with elevated levels of prostaglandins and leukotrienes. DuP 654, a 2-substituted 1-naphthol, is an exceptionally potent inhibitor of 5-lipoxygenase. DuP 654 was tested in various models of skin inflammation and was found to be potent at inhibiting edema induced by the topical application of arachidonic acid, tetradecanoyl phorbol acetate or the calcium ionophore A23187. DuP 654 was also effective in a murine model of contact sensitivity. DuP 654 was effective at reducing the numbers of infiltrating polymorphonuclear leukocytes in AA and TPA induced edema. These data, taken together, suggest that DuP 654 may be effective in treating human skin diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972803
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...