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  • 1
    Electronic Resource
    Electronic Resource
    Investigation of the Substrate (1995)
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 47-48 (July 1995), p. 485-490 
    Details
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/25/transtech_doi~10.4028%252Fwww.scientific.net%252FSSP.47-48.485.pdf
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  • 2
    Electronic Resource
    Electronic Resource
    Improvement of blood glucose control in IDDM patients retards the progression of morphological changes in early diabetic nephropathy (1994)
    Springer
    Diabetologia 37 (1994), S. 483-490 
    Details
    ISSN: 1432-0428
    Keywords: Key words Diabetic glomerulopathy, microalbuminuria, basement membrane thickness, mesangial expansion, mesangial matrix, stereology, hyperglycaemia.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We investigated in a randomized, prospective study the influence of improved blood glucose control during 2–3 years in young insulin-dependent diabetic (IDDM) patients with microalbuminuria, which is indicative of early nephropathy. Patients were randomized either to intensive treatment by continuous subcutaneous insulin infusion (CSII) (n =9) or CT (n =9). Kidney biopsies were taken at baseline and after 26–34 months. End points were structural changes in the glomeruli. Sensitive, quantitative, morphometric methods were used. The blood glucose control improved significantly (p =0.01) during the study in the CSII-group as glycated haemoglobin (HbA1 c) fell from 10.1 % ([95 % CI] 8.9–11.3) to 8.6 % (7.9–9.2), but not in the CT-group, 10.1 % (8.3–11.9) vs 9.7 % (8.7–10.8). Mean HbA1 c during the study period was significantly lower in the CSII-group than in the CT-group, 8.7 % (8.1–9.3) vs 9.9 % (8.5–11.3), p =0.04. Basement membrane thickness (BMT) increased in both groups, most (CT vs CSII, p =0.03) in the CT-group: 140 nm (50–230) vs CSII: 56 nm (27–86). In the CT-group only an increase was seen in matrix/mesangial volume fraction (p =0.006) and matrix star volume (p =0.04). Furthermore, a positive correlation between mean HbA1 c during the study and change from baseline in BMT (r =0.70, p =0.001) and matrix/glomerular volume fraction (r =0.33, p =0.09, NS) was demonstrated. Albumin excretion rate correlated significantly to BMT and most of the matrix parameters. The present study shows that during a period of only 2.5 years, a close relationship between the level of mean blood glucose and progression of glomerular morphological changes in early diabetic nephropathy can be demonstrated. [Diabetologia (1994) 37: 483–490]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050136
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  • 3
    Electronic Resource
    Electronic Resource
    Long-term metabolic control in recipients of combined pancreas and kidney transplants (1991)
    Springer
    Diabetologia 34 (1991), S. S68 
    Details
    ISSN: 1432-0428
    Keywords: Combined Pancreas ; Kidney ; Transplantation Glucose ; Metabolism Long-term
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Metabolic glucose control was followed in 36 patients at 12-month intervals for up to 5 years after a successful combined kidney and segmental duct-occluded pancreas transplantation. All recipients had normal blood glucose levels at each examination. HbA1 values, intravenous glucose tolerance test, C-peptide levels and C-peptide responses to glucagon stimulation were also, on average, within the normal range. Several individual patients had, however, abnormal values for these parameters. At most 46% had abnormal values for HbA1 and intravenous glucose tolerance test, up to 13% showed low C-peptide values and up to 46% of the stimulated C-peptide responses were inadequate at the different intervals. These parameters did not deteriorate with time. This was true both for the whole group of patients as well as for the 6 patients with a 5-year observation time evaluated separately. Despite these abnormalities in glucose metabolism, all patients remained normoglycaemic without need for exogenous insulin up to 5 years after transplantation. The long-term ability of duct-occluded segmental pancreatic grafts to preserve euglycaemia therefore seems to remain intact at least for 5 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587623
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  • 4
    Electronic Resource
    Electronic Resource
    Rehabilitation and quality of life in diabetic patients after successful pancreas-kidney transplantation (1991)
    Springer
    Diabetologia 34 (1991), S. S158 
    Details
    ISSN: 1432-0428
    Keywords: Pancreas transplantation ; Diabetes ; Organ complications ; Rehabilitation ; Quality of life
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty-seven Type I diabetic patients in end-stage renal failure were followed after combined pancreas-kidney transplantation. All patients received duct-occluded segmental pancreas grafts. Clinical progression of extrarenal diabetic complications was studied in 11 patients with long-term functioning pancreatic and renal transplants (Group 1), and in 16 patients who had lost pancreatic graft function, but retained renal graft function (Group 2). Pretransplant, extrarenal diabetic complications were equally distributed in the two groups. In the follow-up period, however, the progress of these complications was less severe in patients with functioning pancreatic transplants. No differences were found between the groups concerning rehabilitation, working capacity, need of help or hospital admittance. It is suggested that pancreas transplantation performed in an earlier stage of diabetes before serious complications have developed, would probably improve rehabilitation and quality of life in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00587645
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  • 5
    Electronic Resource
    Electronic Resource
    Über die Wirkung von Kathodenstrahlen auf lebendes Gewebe (1924)
    Springer
    Development genes and evolution 103 (1924), S. 95-167 
    Details
    ISSN: 1432-041X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02107092
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  • 6
    Electronic Resource
    Electronic Resource
    Über eine Doppelbildung des Unterkiefers bei einem 6 Monate alten menschlichen Fetus (1934)
    Springer
    Anatomy and embryology 102 (1934), S. 655-660 
    Details
    ISSN: 1432-0568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02137786
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  • 7
    Electronic Resource
    Electronic Resource
    Über den feineren Bau der Milz bei urodelen Amphibien. (Axolotl) (1926)
    Springer
    Anatomy and embryology 80 (1926), S. 454-491 
    Details
    ISSN: 1432-0568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02136013
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  • 8
    Electronic Resource
    Electronic Resource
    Die Entstehung der ersten Gefäßbahnen bei Embryonen urodeler Amphibien (Salamandra atra und Axolotl) bis zur Rückbildung des Dotterkreislaufs (1923)
    Springer
    Anatomy and embryology 70 (1923), S. 260-307 
    Details
    ISSN: 1432-0568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02117180
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of dexamethasone on serum protein extravasation in experimental brain infarcts of monkey: An immunohistochemical study (1985)
    Springer
    Acta neuropathologica 65 (1985), S. 255-260 
    Details
    ISSN: 1432-0533
    Keywords: Experimental infarcts ; Monkeys ; Brain edema ; Morphometry ; PAP staining
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Experimental brain infarcts were produced in 12 adult baboons (Papio cynocephalus) by transorbital permanent clipping of the left middle cerebral artery. One group (seven monkeys) received daily injections of 1 mg/kg dexamethasone, starting 1 h after vascular occlusion and continuing till the end of the experiment. Another group (five monkeys) was not treated. One week after vascular occlusion the volume of infarcts and peri-infarct edema was estimated morphometrically on histological sections, using Masson's trichrome stain and the peroxidase-anti-peroxidase (PAP) technique for visualization of serum protein extravasation. In the untreated animals the average volume of infarct was 6.57±4.23% (mean±SD) and the volume of edema 7.83±2.93% of ipsilateral hemisphere. In the treated animals the infarct volume was not different (7.95±3.00%), but the volume of peri-infarct edema was significantly lower (2.82±3.06%,p〈0.05). The results obtained indicate that dexamethasone treatment reduces the development of peri-infarct edema but does not influence the size of infarcts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687005
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  • 10
    Electronic Resource
    Electronic Resource
    Carotid artery stenosis and tachyarrhythmias: regional cerebral blood flow during high-rate ventricular pacing after one vessel occlusion in rats (1994)
    Springer
    Journal of molecular medicine 72 (1994), S. 775-781 
    Details
    ISSN: 1432-1440
    Keywords: Cerebral blood flow ; Carotid stenosis ; Microspheres ; Ventricular tachycardia ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The aim of the present study was to investigate the effect of hypotensive tachycardias on cerebral blood flow (CBF) in the presence of significant carotid stenosis. The experiments were performed in 57 spontaneously breathing rats during arterial normoxia and normocapnia anesthetized with thiobarbital. CBF was determined with radio-labeled microspheres during control conditions (normofrequent sinus rhythm, normotension; group A; n = 15), during high-rate left ventricular pacing (660–840 ppm) at normotension (group B1; n = 13), borderline hypotension (group B2; n = 15) and severe hypotension (group B3; n = 7). In addition, CBF measurements were performed during borderline hypotension induced by hemorrhage (group C; n = 7). Global CBF was 1.09 ± 0.29 ml g−1 min−1 in group A, 0.93 ± 0.40 in group B1, 0.68 ± 0.31 in group B2 (P 〈 0.05 vs. A), 0.42 ± 0.16 in group B3 (P 〈 0.05 vs. A) and 0.83 ± 0.2 in group C. The highest CBF values were found in the cerebellum (A; 1.43 ± 0.5 ml g−1 min−) and the lowest in the postocclusive tissue of the ipsilateral hemisphere (A; 0.74 ± 0.2 ml g−1 min−1). In all groups a 15% mean CBF reduction in the right hemispherical cerebrum in comparison to the left hemisphere was observed (P 〈 0.01). In contrast, hemispherical CBF of the cerebellum did not differ. The CBF blood pressure relationship shifted to lower CBF values, the threshold of CBF regulation shifted to higher blood pressure values in the tissue regions distal to the occluded vessel during hypotensive tachycardias. One carotid artery occlusion and high rate ventricular pacing seem to be a reliable model for quantifying cerebral hemodynamics during arrhythmias in the presence of carotid stenoses. Using this experimental approach it was demonstrated that hypotensive tachycardias and obstructions within the ectracranial carotid vascular bed such as arterial vessel stenoses and occlusions have an additive effect on CBF reduction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00180546
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