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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 12 (1964), S. 59-61 
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1449-1451 
    ISSN: 1420-9071
    Keywords: Aldosterone ; kidney ; thymidine kinase activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Thymidine kinase activity was studied in kidneys from immature male rats after administration of aldosterone. Kinetic studies showed that the enzyme activity reached its maximum level 24 h after aldosterone injection. That increase was specific for aldosterone and could be related to the synthesis of new molecules of enzyme.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0428
    Keywords: insulin-like growth factor II ; rat hepatocyte culture ; liver metabolism ; hepatic endocytosis ; lysosomal enzymes ; insulin binding ; insulin-like growth factor II binding ; insulin-like growth factor II receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Short- and long-term regulation of hepatic carbohydrate metabolism by insulin-like growth factor II was studied in primary cultures of adult rat hepatocytes and compared to the metabolic potency of insulin. Insulin-like growth factor II stimulated glycogen synthesis from [14C]glucose, uptake of [3H]aminoisobutyric acid and [14C]lactate formation from [14C]glucose up to three-fold. Basal glycogenolysis was inhibited to about 10%, and glucagon-activated glycogenolysis was blocked completely. The enzymatic activity of glucokinase and pyruvate kinase was induced two-fold, the glucagon-dependent induction of phosphoenolpyruvate carboxykinase was antagonized. Compared to insulin, half-maximal responses required up to 50 times higher insulin-like growth factor II concentrations ranging from 10–20 nmol/l. A similar difference was observed for binding affinity of insulin-like growth factor II to the insulin receptor. The interaction with the insulin-like growth factor II/man-nose 6-phosphate (IGF-II/Man-6-P) receptor was examined by studying 125I-insulin-like growth factor II binding and uptake of lysosomal enzymes. The affinity of insulin-like growth factor II to the IGF-II/Man-6-P receptor was considerably higher than for the insulin receptor. Antibodies against the IGF-II/Man-6-P receptor did not affect metabolic responses to insulin-like growth factor II, while binding to its receptor and the receptor-mediated endocytosis of arylsulphatase A were strongly inhibited. Thus, in adult rat liver insulin-like growth factor II appeared to exert metabolic actions not via interaction with its own receptor but through low affinity binding to hepatic insulin receptors.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 34 (1991), S. 144-149 
    ISSN: 1432-0428
    Keywords: Insulin ; insulin-like growth factor I ; euglycaemic clamping ; glucose metabolism ; lipogenesis ; glycogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The acute metabolic actions of insulin-like growth factor I were studied in anaesthetized adult rats and its potency was compared to that of insulin. Following an i. v. bolus injection of insulin-like growth factor I a dose-dependent decrease of blood glucose and serum non-esterified fatty acid concentrations was noted with a potency of about 2% that of insulin. Stimulation of total body glucose disposal during euglycaemic clamping required ∼ 50times higher insulin-like growth factor I serum concentrations to achieve an identical half-maximal response. A similar difference in potency was observed for the stimulatory action on 2-de-oxyglucose uptake and on glycogen formation in skeletal muscle. Lipogenesis in epididymal fat pads was increased dose-dependently by both hormones requiring approximately 30 times higher half-maximally effective serum concentrations of insulin-like growth factor I. These data demonstrate that insulin-like growth factor I exerted acute insulin-like metabolic actions in vivo with low potency. These effects were probably mediated via insulin receptors. A preferential stimulation of glucose metabolism in skeletal muscle was not observed.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 35 (1992), S. 932-938 
    ISSN: 1432-0428
    Keywords: Insulin-like growth factor II ; insulin action ; euglycaemic clamping ; glucose metabolism ; lipogenesis ; glycogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The metabolic potency of recombinant human insulin-like growth factor II was studied in anaesthetized adult rats by obtaining dose-response curves for the hypoglycaemic action and for the stimulation of glucose metabolism during euglycaemic clamping. Compared to insulin, about 50 times higher doses of insulin-like growth factor II were required to result in identical in vivo responses, with half-maximally effective serum concentrations for the stimulation of glucose disposal during clamp studies of about 0.8 and 50 pmol/ml, respectively. A similar difference in potency was observed for the dose-dependent stimulatory actions on glucose metabolism in individual target tissues. Half-maximally effective serum concentrations in the range of 0.8 to 3.0 pmol/ml for insulin and of 40 to 70 pmol/ml for insulin-like growth factor II were seen to be required for 2-deoxyglucose uptake, glycogen formation in skeletal muscle and lipogenesis in epididymal fat. Maximal responses were identical with both peptides. These data suggest that in vivo acute metabolic actions of insulin-like growth factor II on carbohydrate metabolism occurred through insulin receptors.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 11 (1968), S. 275-281 
    ISSN: 1432-0533
    Keywords: RNA ; Nerve Cell ; Axon ; Iminodipropionitrile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der RNS-Gehalt einzelner Nervenzellkörper aus dem Vorderhorn des Rückenmarks der Ratte zeigt keine Zunahme während der 12 wöchigen IDPN (β,β-Iminodipropionitril)-Fütterung, doch wurde während der letzten 4 Wochen eine geringe Verminderung beobachtet. Die RNS-Konzentration in den Axon-Ballons beträgt 0,23%, verglichen mit 5,3% in den Nervenzellkörpern. Der Adenin/Uracil (A/U)-Quotient der RNS in den Axonballonen beträgt 0,61 gegenüber 0,90 in den Perikaryen der normalen Nervenzellen. Der A/U-Quotient von RNS in den Zellkörpern von Ratten, die mit IDPN gefüttert wurden, ist auf 0,68 reduziert (6–8 Wochen), während er für Ratten, die 1–12 Wochen lang mit IDPN gefüttert wurden, 0,77 beträgt.
    Notes: Summary The RNA content of single nerve cell bodies from the anterior horn of rat spinal cord shows no increase during the 12 weeks of feeding of IDPN (β,β-iminodipropionitrile), but a slight decrease is noted during the last four weeks. The RNA concentration in the axonal balloons is only 0.23% as compared to 5.3% in the nerve cell body. The A/U ratio of RNA in the axonal balloons is 0.61 as compared to 0.90 in cell bodies of normal nerve cells. The A/U ratio of RNA in cell bodies of rats fed IDPN is also reduced to 0.68 (6–8 weeks) while the A/U for rats fed IDPN for 1–12 weeks is 0.77.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 61 (1983), S. 169-172 
    ISSN: 1432-0533
    Keywords: Neuroaxonal spheroids ; Catecholamines ; Alzheimer's disease ; Pontocerebellar degeneration ; Motor neuron disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuroaxonal spheroids became evident microscopically after the autopsy of a 45-year-old woman with pigmentation of the globus pallidus suggesting Hallervorden-Spatz disease. In our opinion the fine floccular pigment seen electron-microscopically in many of the axonal spheroids is melanin, an end product of catecholamine metabolism. Neurofibrillary degeneration, senile plaques, and granulovacuolar degeneration in the hippocampus produced a picture of Alzheimer's disease. Pontocerebellar degeneration and motor neuron disease were also observed.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 16 (1970), S. 154-160 
    ISSN: 1432-0533
    Keywords: Hyperactivity ; Succinoxidase Activity ; Reticular Neurons ; β-β-Iminodipropionitrile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Succinooxidaseaktivität einzelner Neurone aus der Formatio reticularis wurde mit der Cartesianischen Tauchertechnik gemessen. Die Durchschnittsaktivität der Nervenzellkörper des Nucleus gigantocellularis sowie des Nucleus pontis caudalis der Kontrollratten war 4,5 μl O2×10−4 pro Stunde bei 37°C. Nachdem die Ratten β-β-Iminodipropionitril bekommen hatten, stieg die Durchschnittsaktivität derselben Neurone bis auf 8.0 μl O2·10−4 an. Es wird angenommen, daß dieser Anstieg für die sich später entwickelnden Hyperaktivitätssymptome ätiologische Bedeutung besitzt. Auch wenn β-β-Iminodipropionitril zu reticulären Neuronen normaler Ratten in vitro gegeben wurde, stieg die Succinooxidaseaktivität bis auf 8,4 μl O2·10−4 pro Stunde an.
    Notes: Summary The succinoxidase activity of single neurons from the reticular formation was measured with the Cartesian diver technique. The average activity of nerve cell bodies from the nucleus gigantocellularis or pontis caudalis from control rats was 4.5 μl O2×10−4 per hour at 37°C. After rats had received β-β-iminodipropionitrile, the succinoxidase activity of the same type neuron increased to an average of 8.0 μl O2×10−4. It was suggested that this increase was of etiological significance for the symptoms of hyperactivity which developed later. Also when β-β-iminodipropionitrile had been added to the reticular neurons from normal rats in vitro, the succinoxidase activity increased to 8.4 μl O2×10−4 per hour.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 20 (1972), S. 122-138 
    ISSN: 1432-0533
    Keywords: Mercury Intoxication ; Nerve Cells ; Dorsal Root Ganglion ; Cerebellum ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary When given to rats, both organic and inorganic mercury compounds were found to be neurotoxic. After CH3HgCl intoxication, focal cytoplasmic degradation was the most characteristic lesion observed in the neurons of the dorsal root ganglion. A large cytoplasmic vacuole was formed in many neurons as a result of such lesions. After HgCl2 poisoning, the dorsal root ganglion neurons developed peripheral vacuoles, which were formed by the retraction of the neuron from its surrounding satellite cells. Extensive fragmentation of these neurons occurred as such vacuolation progressed. Multiple small lesions varying from 0.1–1.2 μ were found in the neuronal cytoplasm after both organic and inorganic mercury intoxication. Mercury could be demonstrated histochemically to have a close association with these lesions. In the anterior horn motoneurons, neither mercury compound produced any permanent pathological lesions in the nerve cell bodies, although there was severe dilatation of the cisternae of the endoplasmic reticulum and the nuclear envelope at early stages of the intoxication. In the cerebellum, both organic and inorganic mercury compounds produced extensive coagulative or lucid changes in the granule cells. Degeneration of the Purkinje cells was also found at late stages of the poisoning.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Heat and mass transfer 12 (1979), S. 269-273 
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Zusammenfassung Es werden analytisch Korrekturfaktoren für den Wärmeübergang und den Lewis-Faktor bestimmt. Dabei ergeben sich unterschiedliche Lösungen für tw〉 t bzw. tw 〈 t.
    Notes: Abstract Correction factors for the heat transfer and the Lewis-number are analytically determined. By that one will get different solutions for tw〉 t or tw 〈 t respectively.
    Type of Medium: Electronic Resource
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