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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 97 (1975), S. 1519-1525 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0428
    Keywords: Secretin ; pancreozymin ; exocrine pancreatic insufficiency ; insulin ; free fatty acids ; glucose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'effet des hormones intestinales sécrétine et pancréozymine sur la sécrétion d'insuline, sur la glycémie, les acides gras et le glycérol a été étudié chez onze malades sans diabète mais ayant une insuffisance pancréatique exocrine d'après des résultats cliniques et chimiques. Un groupe de 30 sujets normaux a été utilisé comme témoins. Les hormones intestinales n'ont causé aucune augmentation d'insuline dans le sérum des malades ayant une insuffisance pancréatique exocrine. La sécrétion d'insuline après l'injection intraveineuse de glucose était normale. Il semble que la présence du tissu exocrine du pancréas soit nécessaire pour obtenir une stimulation de la sécrétion d'insuline par la sécrétine et la pancréozymine. Comme il était prévu, il n'y a pas eu chez ces malades — contrairement à ce qui se passe chez les personnes normales — de sécrétion d'insuline différente après l'application de glucose oral et intraveineux. Ces résultats montrent que la similitude des modifications de l'insuline plasmatique après administration de glucose par voie orale et parentérale peut signifier un mauvais fonctionnement du pancréas exocrine. On peut en déduire qu'un récepteur du glucose de la cellule bêta ou de la membrane superficielle peut opérer indépendamment du tissu pancréatique exocrine et des hormones intestinales. D'autre part, il est proposé comme conclusion qu'un «entérorécepteur» de la cellule bêta est sensible à l'action des hormones intestinales et qu'il est dépendant, plus ou moins, d'un tissu pancréatique exocrine.
    Abstract: Zusammenfassung Bei 11 nicht-diabetischen Patienten mit klinisch und laborchemisch nachgewiesener chronischer exkretorischen Pankreasinsuffizienz wurde die Wirkung der intestinalen Hormone Sekretin und Pankreozymin auf die Insulinsekretion, den Blutzucker, die freien Fettsäuren und das Glycerin untersucht und verglichen mit den an 30 normalen Versuchspersonen gewonnenen Befunden. — Bei den Patienten mit exkretorischer Pankreasinsuffizienz bewirkten die oben genannten intestinalen Hormone keine Erhöhung des Seruminsulins, obwohl die Insulinsekretion nach der i.v. Verabreichung von Glucose nicht beeinträchtigt war. Offensichtlich ist für eine Insulinausschüttung nach Sekretin und Pankreozymin beim Menschen ein intaktes exkretorisches Pankreas erforderlich. Erwartungsgemäß konnte bei diesen Patienten, im Gegensatz zu Normalpersonen, kein Unterschied in der Insulinausschüttung nach oraler und intravenöser Verabreichung von Glucose festgestellt werden. Aus diesen Ergebnissen ist zu schließen, daß die Ähnlichkeit der Plasmainsulin-Veränderungen nach oraler und parenteraler Gabe von Glucose bereits auf einen frühen Schaden der exokrinen Pankreasfunktion hinweisen könnte. Man kann daraus die Folgerung ziehen, daß ein (hypothetischer) „Glucose receptor“ derβ-Zelle oder ihrer Oberflächenmembran mehr oder weniger unabhängig von exokrinem Pankreasgewebe und intestinalen Hormonen funktioniert. Andererseits scheint der „Entero-Rezeptor“ derβ-Zelle, der auf die insulinstimulierende Wirkung der intestinalen Hormone reagiert, mehr oder weniger abhängig zu sein von ausreichendem Vorhandensein intakten exokrinen Pankreasgewebes.
    Notes: Summary In 11 non-diabetic patients with clinical and laboratory evidence of chronic exocrine pancreatic insufficiency, the effect of intestinal hormones secretin and pancreozymin upon insulin secretion, blood sugar, free fatty acids and glycerol was studied and compared with the findings obtained in 30 normal volunteers. — In the patients suffering from exocrine pancreatic insufficiency the above mentioned enterohormones did not elicit any increase in serum insulin although insulin secretion after i.v. glucose loads was perfectly undisturbed. Obviously, the mediator inducing insulin release following secretin and pancreozymin in man depends on intact exocrine pancreatic tissue. As had been expected, no differences in the serum-insulin responses to oral and intravenous glucose, as found in normals, were established in these patients. From theses results it is inferred that similarity of plasma insulin changes after oral and parenteral glucose loads might hint at an early impairment of exocrine pancreatic tissue function. That implies, that a (hypothetical) “Glucose receptor” of theβ-cell or its surface works more or less independently of both the exocrine pancreatic tissue and the intestinal hormones. On the other hand, the “Entero-receptor” of theβ-cell responding to the insulin-stimulating action of intestinal hormones, such as secretin and pancreozymin, is likely to be more or less dependent upon sufficient amounts of intact exocrine pancreatic tissue.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Lung 74 (1930), S. 109-127 
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 48 (1979), S. 215-236 
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The lateral mobility of pyrene, pyrene decanoic acid, and 1-palmitoyl-2-pyrene decanoyl-phosphatidyl choline (pyrene lecithin) in lipid bilayers is determined by the excimer formation technique. This method is applied to vesicles of lecithins differing in chain length and in the degree of saturation of the hydrocarbon chains. These values are compared with results in cephalins of different chain length and in dipalmitoyl phosphatidic acid at variable pH. The influence of cholesterol is investigated. The results are analyzed in terms of the Montroll model of two-dimensional random walk. The jump frequency of the probe molecule within the lipid lattice is obtained. The advantage of this measure of transport in lipid layers is that it does not involve lipid lattice parameters. The main results of the present work are: (i) The lateral mobility of a given solute molecule in lamellae of saturated lecithins is independent of hydrocarbon chain length and rather a universal function of temperature. (ii) In unsaturated dioleyl lecithin the amphiphatic molecules have lateral mobilities of the same size as in saturated lipids. The jump frequency of pyrene, however, is by a factor of two larger in the unsaturated lecithin. (iii) The jump frequencies in phosphatidyl ethanolamines are about equal to those in lecithins. (iv) In phosphatidic acid layers the hopping frequencies depend on the chargers of the head groups of both the lipids and the probes. (v) Cholesterol strongly reduces the jump frequency in fluid layers. (vi) The lateral mobility in biological membranes is comparable to that in artificial lipid bilayers. The experimental results are discussed in terms of the free volume model of diffusion in fluids. Good agreement with the predictions made from this model is found. A striking result is the observation of a tilt in dioleyl-lecithin bilayer membranes from the hopping frequencies of pyrene and pyrene lecithin. A tilt angle of ϕ-17° is estimated.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 23 (1980), S. 107-112 
    ISSN: 1432-0630
    Keywords: 46.30 Jv ; 68.10 Et ; 46.30 Rc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Mechanical strains along oxide edges of semiconductor devices with oxide isolation were studied by real-time x-ray topography in the temperature range from 20 to 1100°C. Due to the different thermal expansion coefficients of silicon and oxide, the strain at these edges decreases continuously with increasing temperature. The strength of the strain pattern corresponds to the structure size. The strain depends also on the thickness of the Si3N4 layer though the nitride was removed before the experiment. During the first heat treatment the contrast splits up into two lines at about 780°C.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1076
    Keywords: Key words Anthracycline ; Cardiomyopathy ; Echocardiography ; Impedance cardiography ; Physical exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the long-term effects of anthracyclines on the myocardium of the young child we examined 34 patients who had been treated with anthracyclines in childhood. In addition to anthracycline, the patients were treated with other potentially cardiotoxic substances within the framework of different protocols. The mean cumulative anthracycline dose was 128.6 mg/m2, the average age at onset of chemotherapy 4.2 years, and the time interval after discontinuation of treatment 9.0 years. The cardiological examination consisted of a physical examination, electrocardiography and echocardiography, including Doppler and bio-impedance cardiography. The patients were studied at rest and after physical exercise with a cycle ergometer test in a supine position. The results of the physical examination, the electrocardiogram at rest and the 24 h Holter monitoring were normal. The left ventricular enddiastolic diameter, shortening fraction, velocity of fibre shortening (VCF), the diastolic flow profile at the mitral valve level and the cardiac stroke volume at rest were also normal. However, the shortening fraction (SF) was below the margin of 2 standard deviations in two patients and the VCF in three patients. There was a significant reduction in septal thickness, (–1.4 SD, P 〈 0.0004), in the width of left ventricular posterior wall (–1.5 SD, P 〉 0.0002) and in the left ventricular myocardial mass (–0.76 SD, P = 0.0042). Physical working capacity was normal. Immediately after physical stress the expected rise of SF and VCF did not occur and the SF fell below the values at rest. In comparison to a healthy control group the SF and the VCF were markedly decreased (P 〉 0.0001). The stroke volume decreased by 14 % compared to the pre-exercise value. Conclusion Chemotherapy with anthracyclines, even in low dosages, results in myocardial damage, which does not however, effect physical capacity over a long period but which is revealed by reduced left ventricular wall thickness and myocardial mass. Functional effects include insufficient increase of SF, VCF and stroke volume during physical exercise.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1076
    Keywords: Anthracycline ; Cardiomyopathy ; Echocardiography ; Impedance cardiography ; Physical exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the long-term effects of anthracyclines on the myocardium of the young child we examined 34 patients who had been treated with anthracyclines in childhood. In addition to anthracycline, the patients were treated with other potentially cardiotoxic substances within the framework of different protocols. The mean cumulative anthracycline dose was 128.6 mg/m2 the average age at onset of chemotherapy 4.2 years, and the time interval after discontinuation of treatment 9.0 years. The cardiological examination consisted of a physical examination, electrocardiography and echocardiography, including Doppler and bio-impedance cardiography. The patients were studied at rest and after physical exercise with a cycle ergometer test in a supine position. The results of the physical examination, the electrocardiogram at rest and the 24 h Holter monitoring were normal. The left ventricular enddiastolic diameter, shortening fraction, velocity of fibre shortening (VCF), the diastolic flow profile at the mitral valve level and the cardiac stroke volume at rest were also normal. However, the shortening fraction (SF) was below the margin of 2 standard deviations in two patients and the VCF in three patients. There was a significant reduction in septal thickness, (−1.4 SD,P〈0.0004), in the width of left ventricular posterior wall (−1.5 SD,P〉0.0002) and in the left ventricular myocardial mass (−0.76 SD,P=0.0042). Physical working capacity was normal. Immediately after physical stress the expected rise of SF and VCF did not occur and the SF fell below the values at rest. In comparison to a healthy control group the SF and the VCF were markedly decreased (P〉0.0001). The stroke volume decreased by 14% compared to the pre-exercise value. Conclusion Chemotherapy with anthracyclines even in low dosages, results in myocardial damage, which does not however, effect physical capacity over a long penod but which is revealed by reduced left ventricular wall thickness and myocardial mass. Functional effects include insufficient increase of SF, VCF and stroke volume during physical exercise.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 149 (1990), S. 459-464 
    ISSN: 1432-1076
    Keywords: Newborn ; Erythropoiesis ; Anaemia ; Congenital heart disease ; Renal failure ; Arterial oxygen content
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serum immunoreactive erythropoietin (siEPO) was determined in cord serum from neonates (n=97, gestational age 36–43 weeks), in healthy children from birth to adolescence (n=260) and in children with haematological (n=30), renal (n=10) and congenital heart diseases (n=70). In healthy children siEPO levels decreased after birth (geometric mean cord siEPO 35.6 mU/ml with 95% range of 17–56 mU/ml in eutrophic, nondistressed fetuses) and reached lowest values during the first 2 months (geometric mean siEPO 11.5 mU/ml). Thereafter siEPO levels increased slightly and were constant between 2 months and adolescence. The geometric mean siEPO for healthy children after birth was 18.8 mU/ml with 95% range of 7–47 mU/ml. These estimates were not significantly different from normal adult values. In newborns with fetal distress (n=15) cord siEPO was significantly elevated (geometric mean 63.0 mU/ml;P〈0.001). In children with haematological disease, siEPO and Hb concentration were inversely correlated (log siEPO (mU/ml)=4.1−0.20×Hb (g/dl);r=−0.62;P〈0.0005). This relationship was significantly different in children with chronic renal failure (log siEPO (mU/ml)=0.67+0.035×Hb (g/dl);r=0.50;P=0.1). In children with heart disease the geometric mean siEPO was 19.2 mU/ml with 95% range 8–65 mU/ml for cyanotic (SaO2〈94%) and 17.7 mU/ml with 95% range of 12–36 mU/ml for acyanotic patients. In this group siEPO values were inversely correlated to the arterial oxygen content (log siEPO (mU/ml) =1.61−2.04×oxygen content (l/l);r=−0.28;P〈0.02).
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1017
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
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  • 10
    facet.materialart.
    Unknown
    Berlin : Periodicals Archive Online (PAO)
    Deutsche Zeitschrift für Philosophie. 18:11 (1970) 1349 
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