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  • 1
    Electronic Resource
    Electronic Resource
    Colorimetric determination of galactose and galactose-1-phosphate from dried blood
    Amsterdam : Elsevier
    Clinical Biochemistry 25 (1992), S. 37-39 
    Details
    ISSN: 0009-9120
    Keywords: colorimetry ; galactosemia ; newborn screening
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0009-9120(92)80043-G
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Rapid detection of influenza A neuraminidase subtypes by cDNA amplification coupled to a simple DNA enzyme immunoassay (1994)
    Springer
    Archives of virology 139 (1994), S. 439-444 
    Details
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A newly developed colorimetric method, DNA enzyme immunoassay (DEIA), was applied to the detection of neuraminidase subtypes N1 and N2 of influenza A viruses. Reverse transcription and polymerase chain reaction with universal primers were used for genomic amplification of H1N1, H2N2, and H3N2 strains. Following amplification, an aliquot of the PCR product was hybridized to biotinylated DNA sequences (N1/N2 probes) immobilized on microtiter wells. The hybridization event was revealed by monoclonal antibodies to double stranded DNA in a standard ELISA reaction. The assay described here was able to distinguish accurately between the two neuraminidase subtypes of human influenza A viruses. It is a simple and rapid method facilitating the handling of a large number of samples and therefore seems to be easily applicable to diagnostic laboratories.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01310805
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Neue Influenza A-Subtypen aus Hongkong – H5N1 und H9N2 Konsequenzen aus dem Influenzaausbruch 1997: Plädoyer für einen Pandemieplan (1999)
    Springer
    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 42 (1999), S. 769-775 
    Details
    ISSN: 1437-1588
    Keywords: Schlüsselwörter Influenza ; Pandemie ; Pandemie-Plan ; Key words Influenza ; Pandemic ; Preparedness plan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The occurrence of a new influenza virus subtype in 1997 in Hongkong caused only minor outbreaks due to the swift and determined actions of the institutions involved. However, this incident again made it clear that an influenza pandemic is still a pending threat. As a result the WHO presented a pandemic preparedness plan which is to facilitate the global measures taken to fight an imminent or ongoing pandemic. Strong efforts of influenza surveillance and the coordination of worldwide measures are essential to this plan. Furthermore the WHO suggested the developement and introduction of similar national preparedness plans.
    Notes: Zusammenfassung Nach dem Auftreten eines neuen Influenza A-Subtyps in Hongkong 1997 sind die Erkrankungsausbrüche in der Bevölkerung durch schnelles und konsequentes Handeln aller Beteiligten sehr begrenzt geblieben. Dennoch haben diese Ereignisse die Gefahr einer jederzeit drohenden Influenzapandemie deutlich vor Augen geführt. Als Konsequenz dieser Erfahrungen hat die WHO einen Bereitschaftsplan entwickelt, der dazu dienen soll, durch globale Surveillance neue Influenza-Subtypen frühzeitig zu entdecken und die nachfolgenden Maßnahmen zur Schadensbegrenzung bzw. Eindämmung einer Pandemie möglichst effektiv durchzuführen und weltweit zu koordinieren. Die WHO hat mit dem vorliegenden Plan den Aufruf verbunden, dementsprechende nationale Pläne zu entwickeln.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001030050278
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Rückblick auf die Influenza-Saison 1998/99 (1999)
    Springer
    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 42 (1999), S. 753-757 
    Details
    ISSN: 1437-1588
    Keywords: Schlüsselwörter Influenza ; Sentinel ; Surveillance ; Key words Influenza ; Sentinel ; Surveillance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 1998/99 the influenza season lasted the complete winter. While the early season hit particularly the southern parts of Germany, later on mainly the eastern and northern parts were affected. Over 2000 influenza viruses were isolated and identified as influenza A (H3N2) (67%) or influenza B (33%). All isolates met the expected virus variants which were part of the current vaccine. Altogether, the influenza activity was more intense than in the two previous years.
    Notes: Zusammenfassung Die letzte Influenza-Saison erstreckte sich über den gesamten Winter 1998/99. Zu Beginn war besonders der Süden Deutschlands betroffen, im weiteren Verlauf der Osten und Norden des Landes. Mehr als 2000 Influenzaviren wurden isoliert und als Influenza A(H3N2) (67%) und Influenza B (33%) identifiziert. Alle Viren entsprachen den erwarteten Virusvarianten, die als Komponenten in der Impfstoffkombination verwendet worden sind. Die diesjährige Influenzawelle war insgesamt stärker als in den beiden Jahren zuvor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001030050274
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Klinische Diagnose und Therapie der Influenza Stellenwert epidemiologischer Surveillance-Daten (1999)
    Springer
    Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz 42 (1999), S. 763-768 
    Details
    ISSN: 1437-1588
    Keywords: Schlüsselwörter Influenza ; Klinische Diagnose ; Prädiktiver Wert ; Leitsymptome ; Key words Influenza ; Clinical diagnosis ; Predictive value ; Key-symptoms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary There are no unequivocal symptoms linked to Influenza and hence diagnosis only considering the clinical picture is uncertain. The predictive value of typical symptoms of Influenza depends largely on the incidence of the infection. Some studies and observations indicate a high predictive value when the epidemic situation is additionally considered. Concepts taking into account the epidemic situation of influenza can enhance the proportion of proper diagnoses and thereby the appropriate use of neuraminidase inhibitors, as supplement to vaccine prophylaxis.
    Notes: Zusammenfassung Die Influenza hat keine eindeutigen Symptome, und eine Diagnose allein anhand des klinischen Bildes ist unsicher. Der prädiktive Wert „typischer Symptome” ist von der Häufigkeit der entsprechenden Erkrankung abhängig. Einige Studien und Beobachtungen weisen auf einen hohen prädiktiven Wert „typischer” Influenza-Symptome bei sinnvoller Berücksichtigung der epidemiologischen Situation hin. Konzepte, die diese Zusammenhänge berücksichtigen, können einen sinnvollen Einsatz der Neuraminidase-Inhibitoren – als Ergänzung der Impfprophylaxe – ermöglichen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001030050276
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    Paper (German National Licenses)
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