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  • 1
    Electronic Resource
    Electronic Resource
    Mathematische Modelle in der Hämatologie (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 935-940 
    Details
    ISSN: 1432-1440
    Keywords: Mathematical models ; Blood formation ; Stem cells ; Erythropoiesis ; Thrombopoiesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The use of mathematical models in haematology is shown by some examples concerning stem cell kinetics, erythropoiesis and thrombopoiesis. At first, model assumptions are formulated which include the biological knowledge and some regulatory hypotheses. Then, the reaction of the model on stimulation and suppression is calculated. Finally, by comparison with experimental or clincal data one can evaluate how far the model assumptions are sufficient to understand the measurements. Thus one can exclude wrong hypotheses and identify the important regulatory influences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01550265
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Cerebral complications in Schimke immuno-osseous dysplasia (1997)
    Springer
    European journal of pediatrics 156 (1997), S. 789-791 
    Details
    ISSN: 1432-1076
    Keywords: Key words Schimke immuno-osseous dysplasia ; Spondylo-epiphyseal dysplasia ; White-matter-lesions ; Cerebrovascular complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Schimke immuno-osseous dysplasia is a multisystem disorder consisting of spondylo-epiphysial dysplasia, progressive renal insufficiency due to focal segmental glomerulosclerosis, and immunodeficiency. Cerebrovascular complications have only been described in five patients. Here we report a patient with prominent neurological symptoms most likely caused by transient ischaemic attacks. Conclusion Neurological symptoms consisted of re-peated brief spells of hemiparaesthesia, motoric aphasia and diplopia. MRI studies of the CNS revealed progressive white matter lesions. Morphological changes as well as neurological deficits are compatible with cerebral ischaemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004310050714
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Di-(2-ethylhexyl)-phthalate as plasticizer in PVC respiratory tubing systems: indications of hazardous effects on pulmonary function in mechanically ventilated, preterm infants (1988)
    Springer
    European journal of pediatrics 147 (1988), S. 41-46 
    Details
    ISSN: 1432-1076
    Keywords: Premature infant ; Artificial respiration ; Polyvinyls ; Phthalic acids ; Respiratory distress syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several PVC medical devices contain the plasticizer Di-(2-ethylhexyl)-phthalate (DEHP) in high concentration. Taken systemically DEHP only has minor toxic effects in the human organism. In three preterm infants artifically ventilated with PVC respiratory tubes unusual lung disorders resembling those observed in hyaline membrane disease, verified both clinically and radiologically, were observed during the fourth week of life. It was assumed that these lung disorders were causally related to the exposure to high doses of DEHP, which was released from the walls of the respiratory tubes. DEHP was found in the lung tissue of one patient who died of pneumothorax soon after birth after being artifically ventilated. It is strongly recommended that for disposable PVC respiratory devices the plasticizer DEHP should be used with more restrictions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442609
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Autosomal-dominante kraniometaphysäre Dysplasie (1996)
    Springer
    Monatsschrift Kinderheilkunde 144 (1996), S. 1073-1077 
    Details
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Makrozephalus ; Kraniotubuläre Skelettdysplasie ; Knochenstoffwechsel ; Key words Craniotubular bone dysplasia ; Macrocephaly ; Bone metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Craniometaphyseal Dysplasia (CMD) is a rare congenital osteochondrodysplasia characterized by hyperostosis and sclerosis of the skull and widening of the metaphyseal region of the long bones with clinical manifestation in early childhood. We report on an 18 months old boy with macrocephaly, nasal obstruction and a dysmorphic face (hypertelorism, broad bony overgrowth of the root of the nose, dental irregularities), who's mother had similar but milder stigmata. Radiologic findings of skull and femora of both mother and child allowed the diagnosis. Our investigations of bone metabolism point to an overactivity of osteoblasts. Cranial nerve compression as a typical complication of CMD could be excluded. The nasal obstruction led to a surgical resection of the posterior vomer. Knowledge about this condition allows early diagnosis and therapy of complications.
    Notes: Zusammenfassung Die kraniometaphysäre Dysplasie stellt eine seltene Unterform der sklerosierenden Skelettdysplasien mit klinischer Manifestation im frühen Kleinkindesalter dar, die mit einer deutlichen Sklerose des gesamten Schädels und mit einer Aufweitung der Metaphysen der langen Röhrenknochen einhergeht. Wir berichten über ein zum Zeitpunkt der Diagnosestellung 18 Monate altes männliches Kleinkind, das mit zunehmendem Makrozephalus, chronischer Nasenatmungsbehinderung und einer Gesichtsdysmorphie (Hypertelorismus, breite Nasenwurzel, Zahnirregularitäten) auffällig wurde. Die Mutter des Patienten wies ähnliche Stigmata auf. Durch Röntgenaufnahmen von Schädel und Femur bei Patient und Mutter konnte die Diagnose gestellt werden. Untersuchungen des Knochenstoffwechsels des betroffenen Kindes weisen auf eine Überaktivität der Osteoblasten hin. Eine Hirnnervenkompression als typische Komplikation des Krankheitsbilds konnte ausgeschlossen werden. Die krankheitsbedingte Nasenatmungsbehinderung machte jedoch eine Choanalerweiterung durch Resektion des posterioren Vomer notwendig. Die Kenntnis dieses Krankheitsbilds erlaubt eine rechtzeitige Diagnosestellung und Intervention bei Komplikationen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001120050068
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    The kinetics of hematopoietic stem cells during and after hypoxia (1984)
    Springer
    Annals of hematology 49 (1984), S. 427-439 
    Details
    ISSN: 1432-0584
    Keywords: Hematopoiesis ; Stem cells ; Mathematical model ; Hypoxia ; Posthypoxia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A previously described mathematical model of the hematopoietic stem cell system has been extended to permit a detailed understanding of the data during and after hypoxia. The model includes stem cells, erythroid and granuloid progenitors and precursors. Concerning the intramedullary feedback mechanisms two basic assumptions are made: 1) The fraction “a” of CFU-S in active cell cycle is regulated. Reduced cell densities of CFU-S, progenitors or precursors lead to an accelerated stem cell cycling. Enlarged cell densities suppress cycling. 2) The self renewal probability “p” of CFU-S is also regulated. The normal steady state is described by p=0.5, indicating that on statistical average each dividing mother stem cell is replaced by one daughter stem cell, while the second differentiates. Diminished cell densities of CFU-S or enlarged densities of progenitors and precursors induce a more intensive self renewal (p〉0.5), such that the stem cell number increases. The self renewal probability declines (p〈0.5) if too many CFU-S or too few progenitors and precursors are present. The model reproduces bone marrow data for CFU-S, BFU-E, CFU-C, CFU-E, 59 Fe-uptake and nucleated cells in hypoxia and posthypoxia. Although the ratio of differentiation into the erythroid and granuloid cell lines is kept constant in the model, a changing ratio of CFU-E and CFU-C results. The model suggests that stem cells and progenitor cells are regulated by a regulatory interference of erythropoiesis and granulopoiesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320485
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  • 6
    Electronic Resource
    Electronic Resource
    Die Brutsaison einer städtischen Population der Ringeltaube (Columba palumbus L.) (1989)
    Springer
    European journal of wildlife research 35 (1989), S. 119-124 
    Details
    ISSN: 1439-0574
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Summary The breeding season of the Woodpigeon was studied in 1986 and 1987 on four urban study plots in Wuppertal/Northrhine-Westphalia. Occupied nests were found from May to October with the median in July and the highest number in August/September. The results are discussed with regard to the hunting time for Woodpigeons in the Federal Republic of Germany.
    Abstract: Résumé On a étudié la couvaison du Pigeon ramier sur quatre sites urbains totalisant 192 hectares dans l'agglomération de Wuppertal en Rhénanie-Westphalie. On a trouvé des nids occupés du mois de mai jusqu'au mois d'octobre avec une médiane au mois de juillet en 1986 et un maximum à la fin aoûtdébut septembre. Les résultats sont discutés en relation avec la saison de chasse du Pigeon ramier qui est actuellement d'application en République fédérale allemande.
    Notes: Zusammenfassung Auf vier Probeflächen von insgesamt 192 ha im Stadtgebiet von Wuppertal/Nordrhein-Westfalen wurde 1986 und 1987 die Brutsaison der Ringeltaube ermittelt. Besetzte Nester wurden von Mai bis Oktober gefunden; der Median lag 1986 im Juli, das Maximum Ende August/Anfang September. Die Ergebnisse werden im Hinblick auf die derzeit geltende Jagdzeit auf Ringeltauben in der Bundesrepublik Deutschland diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02242097
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    Paper (German National Licenses)
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