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  • 1
    Electronic Resource
    Electronic Resource
    Cyclooxygenase inhibitors enhance the production of tissue inhibitor-1 of metalloproteinases (TIMP-1) and pro-matrix metalloproteinase 1 (proMMP-1) in human rheumatoid synovial fibroblasts (1997)
    Springer
    Inflammation research 46 (1997), S. 320-323 
    Details
    ISSN: 1420-908X
    Keywords: Key words: TIMP-1 — MMP-1 — Indomethacin — Diclofenac
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Objective and Design: We investigated the influence of cyclooxygenase inhibitors against the production of tissue inhibitor-1 of metalloproteinases (TIMP-1) and pro-matrix metalloproteinase 1 (proMMP-1) in rheumatoid arthritis (RA) synoviocytes.¶Material: Synovial fibroblasts from RA patients were used.¶Treatment: The cells were treated with recombinant human interleukin 1β (rhIL-1β) (100 ng/ml) and/or indomethacin (0.1, 1, 10 μM) and diclofenac (0.1, 1, 10 μM) and/or prostaglandin E2 (PGE2) (1, 10 μM) for 72 h.¶Methods: The amounts of TIMP-1, proMMP-1 and PGE2 was measured by enzyme linked immunosorbent assay (ELISA). Statistical significance was tested with Student's t-test and Dunnett test.¶Results: RhIL-1β augments the production of TIMP-1 and proMMP-1 in synovial fibroblasts from RA patients, and this IL-1-induced production of TIMP-1 and proMMP-1 was further enhanced by treatment with the cyclooxygenase inhibitors, indomethacin and diclofenac. Exogenous PGE2 significantly suppresses indomethacin- and diclofenac-enhanced TIMP-1 and proMMP-1 production.¶Conclusion: PGE2 down-regulates the production of TIMP-1 and proMMP-1 in RA synoviocytes, and cyclooxygenase inhibitors regulate the production of TIMP-1 and proMMP-1 through the inhibition of PGE2 production in inflammation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050194
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  • 2
    Electronic Resource
    Electronic Resource
    An immunoperoxidase study of S-100 protein, lysozyme and NCA protein distribution in histiocytosis X and allied disorders (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 240-242 
    Details
    ISSN: 1432-069X
    Keywords: S-100 Protein ; Lysozyme ; NCA protein ; Histiocytosis X ; Non-X histiocytosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414235
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of a precursor form of cathepsin D in microsomal lumen: Characterization of enzymatic activation and proteolytic processing in vitro
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 148 (1987), S. 335-343 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(87)91115-6
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  • 4
    Electronic Resource
    Electronic Resource
    Stereochemical control of microbial reduction. 2. Reduction of β-keto esters by immobilized bakers' yeast
    Amsterdam : Elsevier
    Tetrahedron Letters 26 (1985), S. 4213-4216 
    Details
    ISSN: 0040-4039
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4039(00)98995-0
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of a soluble pseudo-receptor on verotoxin 2-induced toxicity (2000)
    Springer
    Journal of infection and chemotherapy 6 (2000), S. 21-25 
    Details
    ISSN: 1437-7780
    Keywords: Key words Globotrisylceramide (Gb3) ; Lyso Gb3 ; O-157 ; Verotoxin 2 (VT2) ; Vero cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To neutralize the toxicity of verotoxin (VT) produced by Escherichia coli type O-157, a soluble pseudo-receptor (Lyso Gb3) was synthesized with the deacylated form of the natural receptor, globotrisylceramide (Galα 1-4Galβ1-4-glucosylceramide; Gb3). In this study, we evaluated the characteristics and pharmacological effects of Lyso Gb3, using VT2. It was confirmed that Lyso Gb3 specifically recognized VT2. Lyso Gb3 itself had little influence on the in-vitro growth of Vero cells, but markedly augmented VT2-induced cytotoxicity. In addition, the VT2-induced killing of mice was not decreased, but was, rather, increased by Lyso Gb3. These results indicate that the soluble pseudo-receptor Lyso Gb3 recognized VT2. However, it did not reduce, but, rather, enhanced, VT2-induced toxicity in the presence of the natural receptor, although Lyso Gb3 alone had no toxicity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101560050044
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  • 6
    Electronic Resource
    Electronic Resource
    The role of granzyme B-expressing CD8-positive T cells in apoptosis of keratinocytes in lichen planus (1997)
    Springer
    Archives of dermatological research 289 (1997), S. 527-532 
    Details
    ISSN: 1432-069X
    Keywords: Key words Granzyme B ; Perforin ; Apoptosis ; Lichen planus ; Colloid body ; CD8 cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Epidermal basal cell injury with colloid body formation is a characteristic feature of lichen planus. Infiltrated cells are thought to be responsible for the epidermal injury. Ultrastructural findings of colloid bodies are typical of apoptosis. Granzymes in cytotoxic T lymphocytes are involved in apoptosis probably together with perforin. Based on this background, we analyzed the role of granzyme B in the mechanisms of epidermal injury in lichen planus. On electron microscopy, basal and suprabasal cells showed condensed chromatin and fragmented nuclei which are typical morphological features of apoptosis. Nuclei of colloid bodies were positively stained by the in situ nick end labeling technique indicating that colloid bodies are subsequently formed in the process of apoptosis. Immunohistochemical staining showed CD8-positive infiltrating cells to contain granzyme B. Cells undergoing exocytosis also contained granzyme B. By immunoelectron microscopy, granzyme B molecules were observed to be secreted from a lymphocyte to an apoptotic keratinocyte. These findings suggest that granzyme B-positive CD8 cells seem to induce apoptosis of keratinocytes in lichen planus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050234
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  • 7
    Electronic Resource
    Electronic Resource
    An important role of tumor necrosis factor-α in the induction of adhesion molecules in psoriasis (1998)
    Springer
    Archives of dermatological research 290 (1998), S. 246-252 
    Details
    ISSN: 1432-069X
    Keywords: Key words Psoriasis ; Adhesion molecule ; Cytokine ; Tumor necrosis factor-α
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Recent studies have suggested that cell adhesion plays an important role in the development and regulation of inflammation. To elucidate the mechanisms of regulation of adhesion molecule expression by cytokines in psoriatic lesions, we compared the expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, E-selectin, and P-selectin immunohistochemically in involved and uninvolved psoriatic skin with the expression of these molecules in normal skin, and measured the amounts of tumor necrosis factor-α, interferon-γ, interleukin-1α, and interleukin-1β in the supernatant of freeze-thawed skin specimens using an enzyme-linked immunosorbent assay. There was strong staining for P-selectin on endothelial cells from involved skin. There was also strong staining for intercellular adhesion molecule-1 on keratinocytes, dermal infiltrates, and endothelial cells from involved skin and on endothelial cells from uninvolved skin, and strong staining for vascular cell adhesion molecule-1 on dermal dendritic cells and fibroblasts and for E-selectin on endothelial cells from involved skin. Large amounts of tumor necrosis factor-α were detected in six out of ten specimens of involved skin, but not in uninvolved or normal skin, although interferon-γ was detected in both involved and uninvolved skin to the same extent. Neither interleukin-1α nor interleukin-1β was detected in involved skin. There was strong staining for tumor necrosis factor-α on keratinocytes and endothelial cells from involved skin. These findings suggest that tumor necrosis factor-αmight play an important role in the induction of vascular adhesion molecules in psoriatic lesions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050299
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