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  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructure of cerebellar capillary hemangioblastoma (1985)
    Springer
    Acta neuropathologica 67 (1985), S. 254-264 
    Details
    ISSN: 1432-0533
    Keywords: Capillary ; Cerebellum ; Endothelial cell ; Hemangioblastoma ; Morphometry ; Pericyte ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron microscopy and computerized morphometric techniques were employed to examine pericyte ultrastructure and to assess quantitatively their relationship to endothelial cells in five cases of cerebellar capillary hemangioblastoma. A total of 97 cross-sectioned capillary profiles were studied. Pericyte coverage of capillary ranged from 30.2% to 97.3% with a mean value of 68.7%, which is higher as compared with the available data from the cerebral cortex, skeletal and cardiac muscle, and pulmonary capillaries. The higher pericyte coverage of capillary suggests that pericyte is an active component of cerebellar capillary hemangioblastoma and may have a close functional relationship to endothelial cells. Pericytes contained bundles of parallel microfilaments along the adluminal side and in the terminal processes, and exhibited an intimate “peg-and-socket” relationship with endothelial cells, suggesting a contractile function of pericytes and their possible role in regulating capillary lumina and focal blood flow. The finding of abundant micropinocytic vesicles along the abluminal side of the cytoplasmic membrane indicates an active metabolic exchange between pericytes and the interstitium. It is possible that in cerebellar hemangioblastoma pericytes may act as a mechanical and metabolic monitor barrier for endothelial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687810
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  • 2
    Electronic Resource
    Electronic Resource
    Neuropathologic findings in thanatophoric dysplasia (1984)
    Springer
    Acta neuropathologica 63 (1984), S. 218-228 
    Details
    ISSN: 1432-0533
    Keywords: Thanatophoric dysplasia (dwarfism) ; Cloverleaf skull (Kleeblattschädel) ; Hippocampal malformation ; Neuronal migration ; Neuronal heterotopia ; Neuropathologic findings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neuropathologic study of eight cases of thanatophoric dysplasia (dwarfism) reveals developmental abnormalities including hypoplasia of posterior fossa, megalencephaly, cerebral gyral disorganization, hippocampal malformation, neuronal heterotopia, nuclear dysplasia, and abnormal axonal bundles. There are no noticeable differences in CNS abnormalities between thanatophoric dysplasia with and without cloverleaf skull (Kleeblattschädel). The CNS abnormalities, likely the result of abnormal neuronal migration and cytoarchitectonic disarrangement, are apparently not caused by skeletal abnormalities. The observation suggests that CNS abnormalities represent a characteristic and distinct manifestation of thanatophoric dysplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00685248
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructure of cerebellar capillary hemangioblastoma (1985)
    Springer
    Acta neuropathologica 66 (1985), S. 117-126 
    Details
    ISSN: 1432-0533
    Keywords: Cerebellar hemangioblastoma ; Crystalloid bodies ; Endothelial cells ; Lysosome ; Pinocytic vesicles ; Weibel-Palade bodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The endothelial cells of three cases of cerebellar capillary hemangioblastoma were studied by means of electron microscopy. Crystalloid bodies, not previously described in the vessels of the central nevous system (CNS), were found in 5%–10% of the endothelial cells, more often in the capillaries with small irregular lumens. They were not observed in the pericytes or stromal cells. They were round to polygonal, 0.5–1.0 μm in size and composed of substructural units of parallel thick and thin electron-dense lines with a periodicity of 180–220 Å. They coexisted occasionally with Weibel-Palade bodies but shared no structural correlation with them. The nature and significance of these crystalloid bodies are as yet unknown. Their close association with pinocytic vesicles suggests that the substructural crystalline might be the result of reconstruction of absorbed material from either the vascular lumen or the interstitium. Their subsequent development, associated with lysosomal activity, into intracytoplasmic dense bodies is postulated. Since crystalloid bodies were found only in endothelial cells, particularly those active in proliferation, they may play a pathophysiologic role in relation to angiogenesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688686
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructure of cerebellar capillary hemangioblastoma (1987)
    Springer
    Acta neuropathologica 74 (1987), S. 345-353 
    Details
    ISSN: 1432-0533
    Keywords: Concentric lamellar bodies ; Endoplasmic reticulum ; Cerebellar hemangioblastoma ; Vacuolization ; Stromal cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Concentric lamellar bodies of endoplasmic reticulum (CLB) were found in the stromal cells of all five cases of cerebellar capillary hemangioblastoma studied ultrastructurally. CLB were often present in the stromal cells with voluminous loose cytoplasm, particularly those close to the capillaries. They were rarely seen in small stromal cells with abundant organelles and stromal cells distended by large lipid droplets. Small lipid droplets were usually present in the center or in the vicinity of CLB. Vesiculation and vacuolization of the lamellar arrays of CLB were common. Some vacuolized CLB were transformed into large, varying-shaped, multilocular bodies. Some stromal cells were markedly distended by numerous large vacuoles derived from CLB. Granulo-fibrillary material was frequently present in the vacuolized lamellae. Discharge of vacuoles into the interstitial space was observed. It is suggested that CLB is one of the characteristic ultrastructural features of the stromal cells. They may represent a special type of hyperplasia of the endoplasmic reticulum, but their functional significance is not known.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687211
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  • 5
    Electronic Resource
    Electronic Resource
    A glioependymal cyst of the cerebellopontine angle (1987)
    Springer
    Acta neuropathologica 74 (1987), S. 382-388 
    Details
    ISSN: 1432-0533
    Keywords: Glioependymal cyst ; Heterotopic leptomeningeal neuroglial tissue ; Epithelial cyst ; Cerebellopontine angle ; Ependymal cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Epithelial cysts in the subarachnoid space are infrequently reported and appear to be histogenetically heterogenous. This report describes the gross, immunohistochemical and ultrastructural findings of an asymptomatic isolated 3-cm epithelial cyst in the cerebellopontine angle. The cyst wall was composed of an inner glial layer with a luminal ependymal lining and an outer fibrous layer with no external lining cells. The lining ependymal cells had vacuoles, bleb-like protrusions, normal and abnormal cilia, and microvilli, the later were sometimes distended and detached into the lumen. They possessed neither pinocytic vesicles nor a basement membrane. The glial layer contained astrocytes, glial bundles and ependymal cells, often in pairs and forming intercellular lumina with cilia and microvilli. Some single and paired ependymal cells contained abnormal cilia and intracytoplasmic lumina. The blood vessels within the glial layer had elongated tight junctions and were fenestrated. The glial layer was demarcated from the outer fibrous layer by a continuous basement membrane. This cyst appears to have originated from a leptomeningeal neuroglial heterotopia and may represent a continued proliferative growth rather than degenerative change of the heterotopia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687216
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  • 6
    Electronic Resource
    Electronic Resource
    Subarachnoid epithelial cyst of the cerebellum (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 220-224 
    Details
    ISSN: 1432-0533
    Keywords: Respiratory epithelium ; Cerebellum ; Subarachnoid ; Epithelial cyst ; Kulchitsky cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report describes the immunohistochemical and ultrastructural studies of a subarachnoid epithelial cyst of the cerebellum found incidentally at autopsy of a 76-year-old man. The cyst was composed of an inner epithelial layer, a middle connective tissue layer and an outer arachnoid membrane. The epithelial layer was strongly positive for cytokeratin, carcinoembryonic antigen and epithelial membrane antigen, but negative for glial fibrillary acidic protein, S-100 protein, neuron-specific enolase and vimentin. Ultrastructurally, the epithelial layer had four distinct types of cells: ciliated cells, non-ciliated cells with coated microvilli, basal cells with tonofilaments and desmosomes, and cells with dense-core secretory granules (Kulchitsky cells). The latter two types of cells have not been described previously in epithelial cysts of the CNS. The lining epithelium closely resembled the upper respiratory epithelium. The findings suggest that the cyst was of endodermal rather than neuroectodermal origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688212
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  • 7
    Electronic Resource
    Electronic Resource
    Intraspinal bronchogenic cyst: ultrastructural study of the lining epithelium (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 513-520 
    Details
    ISSN: 1432-0533
    Keywords: Intraspinal ; Bronchogenic cyst ; Enterogenous cyst ; Tracheobronchial epithelium ; Kulchitsky cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This report describes the ultrastructural characters of the lining epithelium of a symptomatic intraspinal bronchogenic cyst at the C5-T2 level of a 21-year-old female. Six distinct cell types were recognized: ciliated cells, non-ciliated cells, and goblet cells that reached the lumen, and basal cells, Kulchitsky cells and undifferentiated cells that were basally located and did not reach the lumen. The microvilli of non-ciliated cells were coated with granulofibrillary material. Discharge of granular contents from goblet cells was noted. Abnormal cilia, particularly compound cilia, were frequent. Complex interdigitations of cytoplasmic membrane with prominent desmosomes were present in the pseudostratified region. Kulchitsky cells contained characteristic membrane-bound dense-core neurosecretory granules. Intraepithelial unmyelinated axons were observed but none were closely associated with Kulchitsky cells. The types of cells forming the lining epithelium of the present cyst and their topographic distribution within the epithelium are very similar to those of the normal tracheobronchial epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687713
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  • 8
    Electronic Resource
    Electronic Resource
    Crystalloid bodies in skeletal muscle of hypothyroid myopathy (1987)
    Springer
    Acta neuropathologica 74 (1987), S. 22-32 
    Details
    ISSN: 1432-0533
    Keywords: Crystalloid bodies ; Hirano bodies ; Basophilic bodies ; Skeletal muscle ; Hypothyroid myopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Crystalloid bodies in skeletal muscle fibers have been described in myopathic and non-myopathic conditions. They have been interpreted as viral, glycogen, protein-glycogen complex, artifacts and of unknown nature. This report described similar crystalloid bodies in the postmortem muscle samples of two patients with hypothyroid myopathy. The crystalloid bodies were preferentially located in the I band and Z line region and in the subsarcolemmal region closely associated with lipofuscin. Some were present within basophilic bodies. They were formed by parallel filaments of 6–10 nm beaded periodically by electron-dense particles of 10–18 nm in a lattice, hexagonal or parallel-ripple pattern. Merging of filaments of crystalloid bodies into actin filaments of the I band was noted. The electron-dense particles stained strongly with periodic acid-thiocarbohydrazide-silver proteinate method for polysaccharides and were unaffected or partially digested by diastase treatment on the ultrathin sections. The filamentous component was neither stained for polysaccharides nor digested by diastase treatment. It is suggested that crystalloid bodies of muscle fibers are composed of two distinct subunits with particles of glycogen complex attached to filaments of unknown nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00688334
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  • 9
    Electronic Resource
    Electronic Resource
    Colloid cysts of the third ventricle: ultrastructural features are compatible with endodermal derivation (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 605-612 
    Details
    ISSN: 1432-0533
    Keywords: Colloid cyst ; Endoderm ; Respiratory epithelium ; Third ventricle ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The histogenesis of colloid cyst of the third ventricle remains unsettled. Ultrastructural and immunohistochemical analyses have suggested the following possible origins: (a) neuroepithelium, including paraphysis, ependyma, choroid plexus and tela chorioidea; and (b) endoderm, including respiratory and enteric epithelium. This report describes the ultrastructural features of the lining epithelium in four cases of colloid cyst. Six distinct cell types were recognized: (1) ciliated cells with occasional abnormal cilia; (2) non-ciliated cells with microvilli coated with granulofibrillary material; (3) goblet cells showing discharge of secretory granules; (4) basal cells with prominent tonofilaments and desmosomes; (5) basal-located cells with elongated electron-lucent cytoplasm and scattered membrane-bound dense-core granules (150–350 nm); and (6) small undifferentiated cells with scanty organelles. Junctional complexes were present in the former four cell types but absent in the latter two. The types of epithelial cells and their topographic distribution within the epithelium are both very similar to those of normal respiratory epithelium and to the lining epithelium of intraspinal bronchogenic cyst. The observations made in the present study are compatible with the hypothesis that colloid cysts of the third ventricle originate from the endoderm, most likely the respiratory epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00299409
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  • 10
    Electronic Resource
    Electronic Resource
    Ciliary claws: their existence in various epithelial cysts of the central nervous system (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 453-456 
    Details
    ISSN: 1432-0533
    Keywords: Ciliary claws ; Ciliary tip ; Colloid cyst ; Bronchogenic cyst ; Epithelial cyst of CNS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We describe claw-like projections and their issociated structures as encountered at the tips of cilia in a cerebellar epithelial cyst, an intraspinal bronchogenic cyst and two colloid cysts of the third ventricle. Ciliary claws appear either as a single structure or as a cluster of two to five projections measuring 22–28 nm in length and 8–10 nm in diameter, extending from the plasma membrane of the ciliary tip. The transmembranous fibrils of the ciliary claws are bound to a multilayered electron-dense disc which is attached by the distal ends of axonemal microtubules. These observations suggest that ciliary claws are common in several types of epithelial cysts of the central nervous system; the presence of these structures supports the premise that the corresponding epithelium is of endodermal origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227675
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