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  • 1
    Electronic Resource
    Electronic Resource
    Akute kombinierte Alpha- und Betarezeptorenblockade bei essentieller Hypertonie: Wirkungen auf Blutdruck, Nierenfunktion, Renin und Aldosteron (1979)
    Springer
    Journal of molecular medicine 57 (1979), S. 731-739 
    Details
    ISSN: 1432-1440
    Keywords: Alpha-beta-adrenergic blockade ; Essential hypertension ; Renal function ; Renin ; Aldosterone ; Alpha- und betaadrenerge Blockade ; essentielle Hypertonie ; Nierenfunktion ; Renin ; Aldosteron
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei sieben Patienten mit unkomplizierter essentieller Hypertonie wurden unter Dauerinfusionsclearance-Bedingungen die Wirkungen einer akuten Blockade der Alpharezeptoren, allein oder in Kombination mit einer chronischen Betarezeptorenblockade, auf Blutdruck, Nierenfunktion, Plasmarenin und Aldosteron untersucht. Akute Alphablockade mit Phentolamin (20 mg intravenös infundiert) verstärkte den blutdrucksenkenden Effekt einer chronischen Betablockade mit Slow-Oxprenolol (160 mg/Tag × 14 Tage) signifikant (−14,5% gegenüber −7,4% systolisch, −12,4% gegenüber −6% diastolisch, 2α jeweils 〈0,05). Unter der kombinierten Rezeptorenblockade nahmen der renale Plasmafluß zu, die glomeruläre Filtration und die Filtrationsfraktion ab (jeweils 2α〈0,05), während die fraktionellen renalen Clearances von Natrium, Kalium, freiem Wasser und “solute load” unverändert blieben. Die Aktivierung der Renin-Angiotensin-Achse, die unter alleiniger Alpharezeptorenblockade auftrat, wurde durch vorausgehende Betarezeptorenblockade verhindert. Diese Befunde zeigen einen günstigen blutdrucksenkenden Effekt einer akuten kombinierten Alphaund Betarezeptorenblockade, ohne unerwünschte Auswirkungen auf Nierenfunktion und Renin-Angiotensin-Achse.
    Notes: Summary In seven patients with uncomplicated essential hypertension the effects of an acute alpha-adrenergic blockade, alone and combined with a chronic beta-adrenergic blockade, on blood pressure, renal function as measured by standard clearance methods, plasma renin activity, and plasma aldosterone were evaluated. Acute alpha-adrenergic blockade with phentolamine (20 mg by intravenous infusion) significantly enhanced the antihypertensive effect of chronic beta-adrenergic blockade with slow-oxprenolol (160 mg/day×14 days) (−14.5% versus −7.4% for pulse pressure, −12.4% versus −6.0% for diastolic pressure, 2α〈0.05). Under combined adrenergic blockade renal plasma flow increased, glomerular filtration rate and filtration fraction decreased (2α〈0.05 each), whereas the fractional clearances of sodium, potassium, free water, and solute load remained unchanged. The activation of the renin-angiotensin-axis, elicited by alpha-adrenergic blockade alone, was suppressed by the preceding beta-adrenergic blockade. These findings demonstrate a favourable antihypertensive action of a combined blockade of alpha-und beta-adrenergic receptor sites without untoward side effects on renal function or the renin-angiotensinaxis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477555
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  • 2
    Electronic Resource
    Electronic Resource
    Antazoline as an adjuvant in immunosuppressive therapy in renal transplant patients (1986)
    Springer
    Journal of molecular medicine 64 (1986), S. 552-557 
    Details
    ISSN: 1432-1440
    Keywords: Antazoline ; Adjuvans immunosuppressive therapy ; Kidney transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The survival of transplanted cadaver kidneys was compared in a group of 33 first-transplant patients treated with antazoline (Antistine) in addition to conventional immunosuppressive therapy (group A) and a group of 36 patients receiving immunosuppressive therapy only (group B). After 1 year, the transplant survival rate was 79% in group A as compared to 56% in group B (P〈0.05). The difference which was still present after 2 and 5 years could not be attributed to any other factors that might have influenced the survival rate. Antazoline appears above all to diminish the intensity of moderately severe rejection episodes, which often lead to graft loss inducing a chronic type of rejection reaction. However, the frequency of rejection crises during the first 4 months and the percentages of patients without rejection or with primary irreversible rejection crises were practically the same in the two groups. The mechanism of action underlying this potentially important immunosuppressive effect of antazoline is as yet not clarified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01735318
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  • 3
    Electronic Resource
    Electronic Resource
    Rapid prototyping (stereolithography) in the management of intra-articular calcaneal fractures (1997)
    Springer
    European radiology 7 (1997), S. 187-191 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Stereolithography ; Rapid prototyping ; Computed tomography ; Calcaneal fracture ; ROC curves
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this study was to evaluate and compare the diagnostic performance of stereolithography vs workstation-based three-dimensional (3D) reformations in intra-articular calcaneal fractures. A total of 30 intra-articular calcaneal fractures were examined using standard radiographs, coronal CT scans, and 2D and 3D reformations. The CT data were transferred to an outside institution, and stereolithograms were produced from photopolymer resin employing a laser beam system. 3D reformations and stereolithograms were analyzed in a blinded fashion by two staff radiologists. Receiver-operating-characteristic (ROC) curves were obtained for six clinically significant fracture components. Standard radiographs, coronal CT scans, and 2D reformations served as the standard of reference. The area under the ROC curves for 3D reformations and stereolithograms were 1.0 and 0.98 for abnormal tuber angles, 0.91 and 0.91 for anterior and middle talo-calcaneal joint involvement, 0.90 and 0.95 for involvement of the posterior talo-calcaneal joint, 0.65 and 0.78 for the presence of a lateral bulge, 0.80 and 0.81 for the involvement of the calcaneocuboidal joint, and 0.62 and 0.67 for the presence of a “tongue-type” fracture. No statistically significant difference was demonstrated for the two methods (Wilcoxon signed-rank test, p = 0.138). Based on our results stereolithograms did not prove to be statistically superior to workstation-based 3D reformations. Stereolithograms may still be useful for teaching purposes and for surgical planning at a thinking-efficacy level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050132
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  • 4
    Electronic Resource
    Electronic Resource
    Contrast media in MR arthrography of the glenohumeral joint: intra-articular gadopentetate vs saline: preliminary results (1997)
    Springer
    European radiology 7 (1997), S. 498-502 
    Details
    ISSN: 1432-1084
    Keywords: Key words: MR arthrography ; Contrast media ; MRI ; Glenohumeral joint ; Rotator cuff
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this investigation was to compare gadopentetate and saline as contrast media in MR arthrograms of the glenohumeral joint. In 60 consecutive patients MR arthrograms with either gadopentetate (n = 26) or saline (n = 34) were performed. After injection of gadopentate, 3D gradient-echo (GE) images were obtained (TR 32 ms, TE 10 ms, flip angle 40 °). With saline, double-echo steady-state images (heavily T2-weighted 3D GE images) were obtained (TR 40 ms, TE 9/45 ms, flip angle 40 °). In the last 14 of these patients T2-weighted turbo spin-echo (SE) images were added (TR 2900 ms, TE 96 ms). Contrast-to-noise ratios standardized for imaging times proved to be superior for the gadolinium arthrograms compared with GE and SE saline arthrograms (intra-articular fluid vs subacromial fat: p = 0.0001 and 0.0008; intra-articular fluid vs supraspinatus tendon: p = 0.0001 and 0.046). Using a qualitative scoring system gadolinium arthrograms were superior to saline arthrograms (p 〈 0.0001 and p 〈 0.0001). Saline arthrograms in combination with GE and SE sequences are inferior to gadopentetate arthrograms with GE sequences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050191
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  • 5
    Electronic Resource
    Electronic Resource
    MR guidance of laser disc decompression: preliminary in vivo experience (1998)
    Springer
    European radiology 8 (1998), S. 592-597 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Spine ; Intervertebral disks ; Lasers ; MR imaging guidance ; MR imaging temperature monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this study was to perform percutaneous laser disc decompression (PLDD) under MR guidance in an open configuration 0.5-T MR system. Following failed conservative treatment for 6 months, eight patients with contained disc herniations were enrolled in the study. Following MR guided introduction of the laser fiber into the targeted disc space, the laser-induced temperature distribution was visualized using a color-coded subtraction technique based on a T1-weighted GRE sequence. In seven patients PLDD could be performed. In all cases laser effects were depicted by MR. In this regard the color-coded technique was found to be superior to conventional magnitude images. Whereas no apparent decrease in the extent of herniation was discovered immediately following PLDD, T2-weighted FSE images showed signal intensity alterations in two of the seven patients. Clinical evaluation, obtained 3–4 months after PLDD, revealed a fair (n = 2) or good (n = 4) response to the treatment. One patient showed no change in symptoms. MR guidance and monitoring of PLDD is feasible within an open 0.5-T system and seems to render PLDD more safe and controllable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050441
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  • 6
    Electronic Resource
    Electronic Resource
    Patient throughput times for orthopedic outpatients in a department of radiology: results of an interdisciplinary quality management program (1999)
    Springer
    European radiology 9 (1999), S. 1381-1384 
    Details
    ISSN: 1432-1084
    Keywords: Key words: Quality assurance ; Radiology and radiologists ; Departmental management ; Design of radiological facilities ; Socioeconomic issues ; Medical economics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The purpose of this project was to employ quality management methods in order to decrease throughput times for orthopedic outpatients sent to the department of radiology. The following intervals were measured at the onset of the study and after 6 and 12 months: (a) between arrivals at outpatient clinic and radiology counter; (b) between arrival at radiology counter and time of last radiograph; and (c) between time of last radiograph and radiology report printing time. After the initial measurement, numerous changes were initiated both in radiology and in orthopedic surgery. The mean interval between arrival at the outpatient clinic and in radiology decreased by one third from 60 min during the first measurement to 40 (p 〈 0.001) and 41 min during the second and third measurement. The proportion of patients with total radiology times of more than 30 min decreased from 41 to 29 % between the first and third measurements (p 〈 0.001). The corresponding results for radiology times of more than 45 min were 17 and 11 % (p = 0.03). A standard type of quality management program can be employed successfully in order to reduce radiology throughput times for orthopedic outpatients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003300050852
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  • 7
    Electronic Resource
    Electronic Resource
    Difference in nitroglycerin dose-response in the venous and arterial beds (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 455-460 
    Details
    ISSN: 1432-1041
    Keywords: nitroglycerin ; plasma concentrations ; haemodynamic effects ; venous distension ; arterial resistance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In twelve healthy volunteers given nitroglycerin sublingually (1.6 mg) or epicutaneously (12 mg), venous distensibility was found to be maximal, even at low plasma concentrations (〈0.2 ng/ml); there was no further change with increasing concentrations. Peripheral arterial resistance, on the other hand, decreased progressively with rising plasma concentrations and no distinct plateau was demonstrable, even at the highest plasma concentration measured (〉2.0 ng/ml).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00874655
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  • 8
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of cefoperazone in patients undergoing chronic ambulatory peritoneal dialysis: Clinical and pathophysiological implications (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 609-612 
    Details
    ISSN: 1432-1041
    Keywords: cefoperazone ; peritoneal dialysis ; pharmacokinetics ; terminal renal failure ; peritonitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of cefoperazone after i.p. and/or i.v. administration were studied in 12 CAPD patients. After i.v. injection, the plasma half-life was 2.65±0.4 h, the total clearance amounting to 70.1±19.2 ml/min. Peritoneal clearance was calculated to be 6.9±1 ml/min. After peritoneal instillation, the bioavailability was 63.9±5%. After repeated i.p. administration, no accumulation of the drug in the body was observed. Thus, cefoperazone can be safely administered for the treatment of peritonitis in CAPD patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543494
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  • 9
    Electronic Resource
    Electronic Resource
    Plasma concentrations and haemodynamic effects of nitroglycerin during and after intravenous infusion in healthy volunteers (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 99-106 
    Details
    ISSN: 1432-1041
    Keywords: nitroglycerin ; i.v. infusion ; plasma level ; haemodynamic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of nitroglycerin, infused intravenously at 3.4 and 7.5 µg/min over 30 min, on haemodynamic parameters were determined in the morning and the afternoon in a randomized, placebo-controlled study in 5 healthy volunteers. The mean steady-state concentrations of nitroglycerin reached in the plasma during the infusions of 3.4 and 7.5 µg/min were 0.35±0.06 ng/ml and 0.64±0.22 ng/ml, respectively. Wide inter-individual variation was noted. The nitroglycerin-induced increase in the orthostatic rise in heart rate and the change in digital-pulse-wave morphology roughly paralleled the plasma concentration, whereas the reduction in systolic blood pressure in the upright position was still evident 15 mins after the infusion, i.e. when nitroglycerin was no longer measurable in plasma. No significant diurnal variation in vascular sensitivity to the vasodilative action of nitroglycerin was demonstrable. The change in pulse-wave morphology resulting from the reduction in peripheral resistance (shift of the dicrotic wave in the descending limb towards the base-line) proved to be the most sensitive haemodynamic parameter.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00545962
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  • 10
    Electronic Resource
    Electronic Resource
    Fehlen von Nierenveränderungen nach langdauernder Kieselsäureverabreichung beim Meerschweinchen; ein Versuch zur ätiologischen Klärung der endemischen Nephropathie im Balkan (1974)
    Springer
    Research in experimental medicine 162 (1974), S. 215-226 
    Details
    ISSN: 1433-8580
    Keywords: Endemic Balkan nephropathy ; Silicic acid toxicity ; Experimental nephropathy ; Guinea pig ; Endemische Balkan-Nephropathie ; Kieselsäuretoxicität ; Experimentelle Nephropathie ; Meerschweinchen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Dem Trinkwasser von 36 Meerschweinchen wurde während 4–11 Monaten reines Kieselsäurekolloid mit einer Partikelgröße von 20–100 Å in einer Konzentration von 300 mg/l, in den letzten 3 Monaten 600 mg/l zugesetzt. Im Vergleich zu 24 Kontrolltieren ließen sich nach einer Expositionsdauer von 4, 8 und 11 Monaten gemessen an Kreatinin-, Harnstoffstickstoff- und Standardbicarbonat-Konzentration im Blut sowie der Eiweißausscheidung im Urin keine Zeichen einer funktionellen Nierenschädigung nachweisen. Die histologische Untersuchung der Nieren der exponierten Versuchstiere nach der gleichen Expositionsdauer ergab wohl mit atypischem basophilem Material in den Sammelrohren, interstitiellen Infiltraten, Nekroseherden und diskreten glomerulären Veränderungen gewisse pathologische Befunde. Diese pathologischen Veränderungen waren jedoch bei den Kontrolltieren ebenso häufig und in gleicher Frequenz nachweisbar. Aus den Versuchen muß geschlossen werden, daß der Zusatz von kolloidaler Kieselsäure zum Trinkwasser in den gewählten Konzentrationen für Meerschweinchen nicht nephrotoxisch wirkt. Diese Resultate sprechen nicht für eine Bedeutung von Silicaten bei der Entstehung der endemischen Balkan-Nephropathie.
    Notes: Summary Pure colloidal silicic acid particles of 20–100 Å were added to the drinking water of 36 guinea pigs for 4–11 months, first in a concentration of 300 mg/l, then as 600 mg/l during the last 3 months. Compared with 24 control animals, concentrations of serum creatinine, BUN and standard bicarbonate as well as urinary protein excretion failed to reveal functional renal disturbances. Histological examination of the kidneys in animals exposed to silicic acid showed pathological atypical material in the collecting ducts, interstititial infiltrations, focal necrotic areas and dicrete glomerular changes. However, as similar changes in equal frequency were also present in the control animals, it would seem that colloidal silicic acid added to drinking water in the above concentrations was not nephrotoxic. These results are not consistent with the hypothesis that silicates are of primary significance in the pathogenesis of Balkan nephropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851243
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