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  • 1
    Electronic Resource
    Electronic Resource
    Effects of angiotensin-converting enzyme inhibition on renal sodium handling after furosemide injection (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. 622-627 
    Details
    ISSN: 1432-1440
    Keywords: Angiotensin-converting enzyme inhibitors ; Cilazapril ; Furosemide ; Natriuresis ; Antinatriuresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The goal of this study was to quantitate the effect of angiotensin-converting enzyme inhibition on renal sodium handling after furosemide injection. The study was carried out on low and normal salt intake to assess potential interaction with salt balance. Eighteen healthy normotensive volunteers were examined in a double placebo-controlled parallel group design. Subjects were randomly put on either low-salt (20 mmol/day) or normal-salt (110 mmol/day) diet. In either arm of the diet volunteers were first treated orally with placebo for 1 week and subsequently with 2.5 mg/day of the angiotensin-converting enzyme inhibitor cilazapril for another 1 week. Cumulative 24-h urinary sodium excretion was measured on the 6th day of the respective week after sham injection and on the 7th day after injection of 40 mg furosemide. Compared to pretreatment with placebo, pretreatment with cilazapril resulted in a higher cumulative sodium excretion after furosemide injection (day 7) than after the sham injection (day 6) on both salt intakes. The difference in natriuresis (cilazapril versus placebo) was evident 2 and 3 h after injection of furosemide. Neither the time of onset nor the magnitude of antinatriuresis were affected by cilazapril. Following furosemide angiotensin II increased significantly even after cilazapril pretreatment. Cilazapril tended to reduce urinary furosemide excretion. At any given urinary furosemide concentration, the increment in urinary sodium excretion was significantly greater with cilazapril irrespective of salt intake. The study shows that (a) cilazapril increases furosemide-induced natriuresis irrespective of salt intake, (b) antinatriuresis is not affected by cilazapril, and (c) angiotensin II levels rise after furosemide on cilazapril in therapeutic doses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00184489
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  • 2
    Electronic Resource
    Electronic Resource
    Glial cell line-derived neurotrophic factor improves survival of ventral mesencephalic grafts to the 6-hydroxydopamine lesioned striatum (1997)
    Springer
    Experimental brain research 116 (1997), S. 29-38 
    Details
    ISSN: 1432-1106
    Keywords: Key words Glial cell line-derived neurotrophic factor ; Striatum ; Nigrostriatal dopaminergic pathway ; Transplants ; Neurotrophic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  One approach to replace lost dopaminergic neurons in Parkinson’s disease is to transplant fetal mesencephalic tissue into the striatum. In an attempt to expand the developmental window useful for grafting of mesencephalic tissue and increase the fiber outgrowth from grafted dopaminergic neurons, we have pretreated fetal mesencephalic tissue with the dopaminotrophic factor glial cell line-derived neurotrophic factor (GDNF). Mesencephalic tissue pieces from embryonic day 18–19 Fischer 344 rats were preincubated for 20 min with GDNF (1 μg/μl) or vehicle. Two tissue pieces were then transplanted into the striatum of rats that had been unilaterally lesioned by medial forebrain bundle injections of 6-hydroxydopamine. The animals were tested for apomorphine-induced rotations prior to intracranial grafting. Host rats received intrastriatal injections of 10 μg GDNF or control solution at 10 days and 4 weeks postgrafting. The animals were tested in the rotometer twice monthly following transplantation. Despite the fact that these transplants were from a suboptimal donor stage, the rotations were significantly decreased in both transplanted groups. Immunohistochemical evaluation of the host brains revealed that the overall size of transplanted mesencephalic tissue was significantly increased in the GDNF-treated animals, and that the average size of transplanted tyrosine hydroxylase (TH)-positive neurons was also increased. Furthermore, we found that the innervation density of surrounding host striatal tissue was significantly increased in the GDNF-treated group, as compared with controls. Taken together, these results suggest that treatment of intrastriatal ventral mesencephalon grafts with GDNF can optimize the conditions for intracranial grafting and thus improve the chances for functional recovery following the intrastriatal grafting procedure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00005741
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  • 3
    Electronic Resource
    Electronic Resource
    Campylobacter colitis in a young child (1982)
    Springer
    European journal of pediatrics 138 (1982), S. 277-280 
    Details
    ISSN: 1432-1076
    Keywords: Campylobacter ; Colitis ; Inflammatory bowel disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report describes a three-year old boy with serological, bacteriological and histological evidence of a colitis caused by Campylobacter jejuni. Symptomatic and histological recovery followed immediately the erradication of Campylobacter jejuni from the faeces by erythromycin. The history is suggestive of a chronic or recurrent infection with onset at 11 months.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441219
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  • 4
    Electronic Resource
    Electronic Resource
    Concentrations of Serum α 2 -Macroglobulin in Twins (1969)
    [s.l.] : Nature Publishing Group
    Nature 221 (1969), S. 289-290 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table : 1. DETAILS OF TWINS STUDIED Serum a2-macroglobulin Storage of serum at No. pairs Age (years) concentration (mg/100 ml.) -20 C (months) studied Mean S.D. Range Mean S.D. Range Mean S.D. Range Female monozygotic 32 19-8 9-6 12-50 396 80 203-622 43.3 1-9 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/221289a0
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  • 5
    Electronic Resource
    Electronic Resource
    Extension: The Face of Plant Pathology (1981)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Phytopathology 19 (1981), S. 51-67 
    Details
    ISSN: 0066-4286
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.py.19.090181.000411
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  • 6
    Electronic Resource
    Electronic Resource
    Epidermal growth factor receptor expression in normal endometrium and endometriosis: an immunohistochemical study (1992)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 99 (1992), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To study epidermal growth factor (EGF) receptor expression in endometrium throughout the menstrual cycle and to compare EGF-receptor expression in endometrium from patients with endometriosis with receptor expression in synchronously sampled endometriosis and in endometrium from healthy women.Design An immunohistochemical study of receptor expression using murine monoclonal antibodies and timed endometrial and endometriotic biopsies.Subjects 25 healthy women and 27 patients with a diagnosis of endometriosis.Results Positive staining for EGF receptors was observed in 24 of 25 samples from normal women and in 26 of 27 endometrial samples from patients with endometriosis. In neither group was there any variation in the intensity of staining throughout the menstrual cycle and both glands and stroma were stained. EGF-receptor expression was observed in the glands of 15 out of 17 endometriotic lesions and in 12 of these biopsies positive staining was also present within endometriotic stroma.Conclusion This study shows no difference in the intensity of staining of EGF receptors in endometrium throughout the menstrual cycle or between the glands of normal endometrium and those of endometriosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1992.tb13756.x
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  • 7
    Electronic Resource
    Electronic Resource
    PLACENTAL PROTEIN 5 (PP5): DEVELOPMENT OF A RADIOIMMUNOASSAY AND MEASUREMENT OF CIRCULATING LEVELS IN NORMAL PREGNANCY (1981)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 88 (1981), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A specific and sensitive, double antibody, solid phase radioimmunoassay was developed for measurement of placental protein 5 (PP5) in serum. A sensitivity limit of 0.8 μg/1 was achieved by pre-incubation with antiserum and use of a small assay volume. Single serum samples from 244 retrospectively proven normal pregnancies were used to construct a normal range of PP5 concentrations. PP5 was detectable at week 7 and rose to reach a maximum mean value of 54 μg/1 at weeks 36–37. Diurnal variation of PP5 concentration was similar to that encountered from day to day, and slightly greater than variation due to the radioimmunoassay. The decline of serum PP5 concentration post partum was initially rapid (half-life 5–14 minutes), but slowed after 0.5–1 hours; immunoreactive PP5 was still detectable seven days after delivery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1981.tb01021.x
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  • 8
    Electronic Resource
    Electronic Resource
    PLACENTAL PROTEIN 5 (PP5) IN COMPLICATED PREGNANCIES (1981)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 88 (1981), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Maternal serum PP5 concentrations were assayed in pregnancies complicated by intrauterine growth retardation, pre-eclampsia, diabetes mellitus, placental abruption and twins. Elevated PP5 levels were noted in twin pregnancies and to a lesser extent in diabetes and pre-eclampsia. Measurement of PP5 was of no value in the detection of fetal growth retardation. The great majority of PP5 levels above the normal range were associated with a placental abnormality.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1981.tb01022.x
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  • 9
    Electronic Resource
    Electronic Resource
    PLASMA LEVELS OF PREGNANCY–SPECIFIC β1–GLYCOPROTEIN IN NORMAL PREGNANCY (1976)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 83 (1976), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pregnancy-specific β1–glycoprotein (PSβG) is a major product of the trophoblast which has only recently been identified. Like human placental lactogen, the concentration of PSβG in maternal blood rises throughout pregnancy until about 34 weeks, thereafter tending to remain constant until term, with only a small day-to-day variation in individuals. The circulating maternal levels of PSβG between 34 weeks and term are about 200 μg/ml, 20 to 30 times greater than the levels of placental lactogen, thus allowing detection and measurement of PSβG by relatively simple techniques. The levels of PSβG are above the normal range in the majority of twin pregnancies. It is suggested that PSβG measurements may be useful in assessing placental function and may help in the detection of multiple pregnancies at an early stage of gestation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1976.tb00743.x
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  • 10
    Electronic Resource
    Electronic Resource
    A SIMPLE AND SENSITIVE RADIOIMMUNOASSAY FOR PREGNANCY-SPECIFIC β1-GLYCOPROTEIN (1977)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 84 (1977), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A simple, sensitive and relatively rapid radioimmunoassay for pregnancy-specific β1-glycoprotein (PSβG) is described. The concentrations of PSβG in plasma from cord blood and in amniotic fluid were approximately 0·1 per cent and 1·0 per cent respectively of the maternal plasma levels. The amniotic fluid PS(3G levels in pregnancies associated with an anencephalic fetus were not significantly different from normal levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1977.tb12657.x
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