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  • 1
    Electronic Resource
    Electronic Resource
    Glucose modulation of aldose reductase mRNA expression and its activity in cultured calf pulmonary artery endothelial cells (1992)
    Springer
    Diabetologia 35 (1992), S. 730-734 
    Details
    ISSN: 1432-0428
    Keywords: Diabetes mellitus ; angiopathy ; endothelial cells ; glucose ; aldose reductase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We examined the effect of glucose on aldose reductase mRNA expression and its activity in calf pulmonary artery endothelial cells. After the cells were exposed to 18 mmol/l glucose, aldose reductase mRNA expression began to increase at 6 h, reached a maximum (about 2.4-fold increase) at 12 h, and thereafter gradually decreased. Aldose reductase activity was found to strongly correlate with aldose reductase mRNA expression after cells were exposed to 18 mmol/l glucose. In contrast, aldose reductase mRNA expression was significantly decreased following exposure to 55 mmol/l glucose. Aldose reductase activity was also decreased at 24 h after 55 mmol/l glucose. The increase in aldose reductase mRNA level caused by glucose was inhibited by 1 μg/ml of actinomycin D. These phenomena appear to be glucose-specific since neither 3-O-methylglucose nor fructose affected the levels of aldose reductase mRNA. We clearly demonstrate that aldose reductase mRNA level and its activity are modulated by glucose in calf pulmonary artery endothelial cells. Our data suggest that activation of aldose reductase in endothelial cells may contribute to the development of diabetic macroangiopathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429092
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  • 2
    Electronic Resource
    Electronic Resource
    Cystic renal cell carcinoma diagnosed by cystofiberscopy (2000)
    Melbourne, Australia : Blackwell Science Pty
    International journal of urology 7 (2000), S. 0 
    Details
    ISSN: 1442-2042
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 64-year-old man suffered from hypertensive syncope and was admitted to Branch Hospital, Faculty of Medicine, The University of Tokyo. On admission he had no symptoms; however, two renal cysts of about 5 cm in diameter were found in his left kidney. Cystofiberscopy with a thin optical fiberscope was performed in addition to puncture and cystography. Cytology revealed class I, but the wall surface of the lower cyst was uneven, fluid-filled, colloid-like and white-gray compared with that seen in the upper cyst. It was diagnosed as renal cell carcinoma (RCC) and left nephrectomy was performed (5 cm in diameter, RCC, papillary tubular, common, clear cell subtype, G2 〉 G1, INF beta, pT2, pMx, pV0, ew(–)).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1442-2042.2000.00161.x
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  • 3
    Electronic Resource
    Electronic Resource
    001 
Treatment of Hypertrophic Scar with the Silicone Cushion (2004)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 12 (2004), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: Various treatments for hypertrophic and keloid scars have been attempted including electron beam irradiation, local triamcinolone injection, oral tranilast administration, use of silicone sheets, and compression therapy using splints. Among them, we have been attempting silicone cushion patching on hypertrophic scar. Methods: Twenty cases (10 males, 10 females) with hypertrophic scar were treated with silicone cushion. Scar surfaces were kept in contact with silicone cushion for as long periods of time as possible every day. Results were assessed in scores using objective findings (redness, bulging, induration) and subjective symptoms (itching, spontaneous pain, tenderness). Results: As for objective findings, redness remained unchanged in one case, but bulging and induration were found improved in all cases. As for subjective symptoms, itching and tenderness were found improved in all cases and clinical course considered proving usefulness of the treatment was obtained. Conclusions: Silicone cushions have highly viscous silicone oil enclosed in the silicone pack designed to generate negative charge electrostatic fields. Generation of adequate and sustaining electrostatic fields is important for useful clinical effect to exhibit on hypertrophic scar recession. Generation of negative charge electrostatic fields was confirmed on potential determination data with an electrostatic field meter as well.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2004.abstractv.x
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  • 4
    Electronic Resource
    Electronic Resource
    009 
Calcium-Zinc Alginate and Recombinant Human bFGF; Its efficacy from the histological standpoint (2004)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 12 (2004), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim: To evaluate the efficacy of wound dressing material, Calcium-Zinc Alginate: Curasorb Zn® as a carrier of the recombinant human bFGF, histological detection was performed. Methods: Full thickness skin defect on the back of Wistar rat was made for four groups; the control group, bFGF group; topical application of recombinant human bFGF for 5 μg per day, Ca-Zn Alginate group; topical use of the dressing and the group that both the bFGF and Ca-Zn Alginate were applied, nine rats for respective group. Results: Significant granulation was noted both bFGF group and Ca-Zn Alginate group compared to the control group. Fibrosis was noted in the control and Ca-Zn Alginate group whereas no fibrosis was noted in the FGF group. Numerous amounts of cells were noted in the FGF group which indicate strong inflammation. Also, marked abscess formation was noted in the bFGF group. The greatest thickness of granulation was obtained in the group that both the bFGF and Ca-Zn Alginate were applied. Conclusions: It was considered that the appropriate use of the carrier for the bFGF is important to control infection. The Ca-Zn Alginate dressing was effective to suppress abscess formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2004.abstractab.x
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  • 5
    Electronic Resource
    Electronic Resource
    General session V
Moderated by Yashihiko Maehara: Reduction of Ischemia-Reperfusion Injury to Skin Flaps by Monoclonal Antibody to Leukocyte Endothelial Adhesion Molecule-1 (2005)
    Oxford, UK; Malden, USA : Blackwell Science Inc
    Wound repair and regeneration 13 (2005), S. 0 
    Details
    ISSN: 1524-475X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Aim:  Ischemia-reperfusion (I-R) injury continues to be a problem for successful free tissue transfer and replantation after prolonged periods of ischemia. It has been shown that leukocytes and vascular endothelial cells release a variety of inflammatory mediators during reperfusion after ischemia. The leukocyte endothelial adhesion molecule-1 (LECAM-1) is a ligand on the endothelium for some of the adhesion receptors on leukocytes. The purpose of this study was to evaluate the blockage of leukocyte-endothelial adhesion by a monoclonal antibody (MAb) to LECAM-1 in skin flaps to prevent I-R injury in rats.Methods:  Male SD rats (225–250 g) were used. A skin flap (45 × 30 mm) supplied by the superficial epigastric A&V including the femoral vessels was isolated unilaterally. The femoral vessels were cross-clamped the epigastric vessels for 9 hours of ischemia. Animals in treated group received MAb to LECAM −1 i.v. 15 minutes prior to reperfusion; those in the control group received normal saline. Skin flap viability was assessed by tracing the outline of viable and nonviable areas. Data were collected for the following 7 days. These data were corroborated with histological evidence on comparable areas of the flap.Results:  Tracing analysis revealed average flap survival area of about 90% in treated group and about 20% in control group (p 〈 0.05). Histopathologically, few inflammatory changes could be observed in treated group, while marked damage was observed in control group.Conclusions:  From this study, we concluded that treating skin flaps with Mab to LECAM -1 was effective for I-R injury after 9 hours of warm ischemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1067-1927.2005.130116s.x
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  • 6
    Electronic Resource
    Electronic Resource
    A criterion for evaluating the number of capsomeres of icosahedral capsids
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/General Subjects 104 (1965), S. 261-273 
    Details
    ISSN: 0304-4165
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0304-4165(65)90243-6
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  • 7
    Electronic Resource
    Electronic Resource
    Study of negatively stained images of sendai virus nucleocapsids using minimum-dose system
    Amsterdam : Elsevier
    Journal of Ultrasructure Research 84 (1983), S. 140-150 
    Details
    ISSN: 0022-5320
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0022-5320(83)90125-9
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  • 8
    Electronic Resource
    Electronic Resource
    Separation of sendai virus glycoproteins by cm-sepharose column chromatography
    Amsterdam : Elsevier
    FEBS Letters 114 (1980), S. 342-346 
    Details
    ISSN: 0014-5793
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(80)81147-1
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  • 9
    Electronic Resource
    Electronic Resource
    Lengths of the nucleocapsids of Newcastle disease and mumps viruses
    Amsterdam : Elsevier
    Journal of Molecular Biology 35 (1968), S. 369-373 
    Details
    ISSN: 0022-2836
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0022-2836(68)80031-2
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Renal oncocytoma (1987)
    Springer
    World journal of urology 5 (1987), S. 71-79 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A decade has now passed since “renal oncocytoma” became a diagnosis of acute interest to urologists, radiologists and pathologists. The number of patients with renal oncocytoma continues to increase; now a total of over 340 reported cases are available for analysis. Approximately 3% of tumors previously diagnosed as renal cell carcinomas are now considered to be renal oncocytomas. The overwhelmingly benign clinical behavior of typical renal oncocytomas seems well established. At present, there is no definitive way to make the diagnosis of renal oncocytoma preoperatively. Because renal oncocytomas are not so rare, clinicians dealing with solid renal tumors must keep in mind this diagnosis and its possible bilateral and multifocal occurrence. Conservative renal parenchyma sparing operations for oncocytomas should be encouraged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00327060
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