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  • 1
    Electronic Resource
    Electronic Resource
    A model for the quantitative study of Arthus (immunologic) hypersensitivity in rats (1975)
    Springer
    Inflammation research 5 (1975), S. 374-377 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A model of reverse passive Arthus (RPA) reaction in the pleural cavity of rats is described. The time course of development of exudate and migration of cells has been examined. It has been found to be complement dependent and dominated by polymorphonuclear cells. The reaction reaches a peak around 6 hours after challenge. Cyclic AMP levels have been measured both intracellularly and extracellularly and have been found to persist at high levels after the waning of the reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02205246
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  • 2
    Electronic Resource
    Electronic Resource
    New types of therapy for the arthropathies and inflammatory disease (1978)
    Springer
    Inflammation research 8 (1978), S. 166-168 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972438
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    New approaches to anti-rheumatic drugs (1976)
    Springer
    Inflammation research 6 (1976), S. 341-345 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01972252
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  • 4
    Electronic Resource
    Electronic Resource
    Pertussis vaccine oedema: An experimental model for the action of penicillamine-like drugs (1976)
    Springer
    Inflammation research 6 (1976), S. 613-617 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A delayed hypersensitivity response was induced in the rat paw using pertussis vaccine. Oedema was measured after the challenging injection.d-Penicillamine and levamisole enhanced the response, while indomethacin suppressed it. This model is useful to distinguish the effects of antiinflammatory drugs from those liked-penicillamine which have a specific activity in rheumatoid arthritis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01971579
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  • 5
    Electronic Resource
    Electronic Resource
    Pertussis vaccine pleurisy: A model of delayed hypersensitivity (1976)
    Springer
    Inflammation research 6 (1976), S. 618-621 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Male Wistar rats have been sensitized toBordetella pertussis using a mixture of Freund's incomplete adjuvant and pertussis organisms. Intrapleural challenge 12 days later with pertussis produced a marked delayed inflammatory response, maximal at 48 hours and dominated by influx of mononuclear cells. Dosing withd-penicillamine (25 mg/kg) and levamisole (5 mg/kg) at the time of challenge produced a significant enhancement of the reaction. A long period of dosing with either drug, or treatment with indomethacin (3 mg/kg), suppressed the response. The relevance of this to the testing and mode of action of antirheumtic drugs is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01971580
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  • 6
    Electronic Resource
    Electronic Resource
    The clinical value of measuring immunoglobulins when assessing penicillamine therapy in rheumatoid arthritis (1988)
    Springer
    Clinical rheumatology 7 (1988), S. 347-353 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Penicillamine ; Immunoglobulins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunoglobulins are often high in active rheumatoid arthritis and fall when treatment with a slow-acting anti-rheumatic drug is instituted. We assessed the value of monitoring immunoglobulins during penicillamine therapy; 145 patients were followed for up to 5 years, IgA, IgM and IgG levels were compared to 12 other clinical and laboratory variables on 903 occasions. Mean levels of IgA and IgG fell by 10–30%. These changes were less than with ESR or clinical measures such as articular index and duration of morning stiffness. Immunoglobulin levels showed weak correlations with other variables. Only a small number of patients had hypogammuglobulineamia. Initially, 5 cases had low IgA with subsequent falls in 3 more. Initially, 2 cases had low IgG with subsequent falls in 5 more. No patients had low IgM levels. These changes seemed clinically irrelevant. Radiological progression was related to IgA levels. Patients with persistently high rates of radiological progression had persistently higher serum IgA. We conclude that IgM gives the most “acute phase” pattern of response. IgA gives more theoretically interesting information, especially concerning radiological progression. There is only a limited amount of clinically valuable information gained from measuring immunoglobulins.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02239191
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  • 7
    Electronic Resource
    Electronic Resource
    Rheumatoid nodules do not predict response to treatment with slow-acting anti-rheumatic drugs (1991)
    Springer
    Clinical rheumatology 10 (1991), S. 384-387 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Rheumatoid Nodules ; Slow-Acting ; Anti-Rheumatic Drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rheumatoid nodules have been associated with a poor long-term prognosis. We investigated whether they predict a poor response to treatment with slow-acting anti-rheumatic drugs (SAARDs). Two hundred and twenty-eight patients with rheumatoid arthritis (RA) were treated for six months with a SAARD. Clinical and laboratory assessments of disease activity were made initially and after 6 months' treatment. Patients were divided into two groups according to the presence or absence of nodules at entry. Twenty-one % had nodules before treatment but their response was no different to patients without nodules (79%), both groups showing improvements in all variables. Males were more likely to develop nodules and had a relative risk of 1.7. High titres of rheumatoid factor correlated with nodules and no sero-negative patients had nodules. We conclude that nodules are not predictive of poor response to treatment with a SAARD, despite their presence being associated with a poor long-term prognosis. One possible implication is that SAARDs themselves, despite an early response, may not effect long-term outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02206657
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  • 8
    Electronic Resource
    Electronic Resource
    Rheumatoid inflammation and joint destruction: cause and effect or parallel phenomena? (1986)
    Springer
    Inflammation research 18 (1986), S. 538-543 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Joint damage is a characteristic and important consequence of rheumatoid arthritis; it is usually considered to be a direct result of the inflammatory synovitis. This view implies that by treating actively the synovial inflammation subsequent joint damage will be reduced and the long-term outlook of patients with rheumatoid arthritis thus improved. However, there is relatively little clinical evidence that suppressing inflammation reduces rheumatoid joint damage. An alternative view is that the mechanisms causing inflammation and those leading to joint destruction are parallel processes related only indirectly. Considerable evidence supports such a concept. Clinical studies show radiological progression of the disease occurs despite improvements in measures of joint inflammation and a reduction in the levels of acute phase proteins. Damage can progress in either actively inflamed hot joints or cool swollen joints. Histopathologically the features of rheumatoid synovitis are non-specific, while the radiological pattern of joint damage is very characteristic. There is evidence that lymphocytic infiltration is not a poor prognostic finding, despite it being a typical feature of inflamed joints. Experimental studies also fail to show a close correlation between inflammation and cartilage damage: this is seen in experimental arthritis, coculturein vitro systems, and the air pouch model of cartilage damage. We suggest that attempts to improve the outcome of rheumatoid arthritis should not merely concentrate on controlling inflammation but should also seek to modify the associated connective tissue changes of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964961
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  • 9
    Electronic Resource
    Electronic Resource
    Intra-articular drug therapy in rheumatoid arthritis (1982)
    Springer
    Rheumatology international 2 (1982), S. 129-132 
    Details
    ISSN: 1437-160X
    Keywords: Indoprofen ; Rheumatoid arthritis ; Intraarticular ; Oral
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six patients (4 men, 2 women) with moderate/large knee effusions due to rheumatoid arthritis (RA) were studied after receiving indoprofen, 25 mg intra-articularly and then 200 mg orally 1 week later. There was significant improvement in pain (t=3.74, P〈0.05), morning stiffness (t=2.91, P〈0.05) and range of movement (t=2.52, P〈0.05) for at least 1 week following the intra-articular injection. The terminal phase plasma half-life after the 200 mg oral dose was 6.4±0.7 h (mean±SEM) and was significantly longer than the often quoted plasma half-life of 2–3 h from previous studies, but much less than the pharmacodynamic half-life. Synovial fluid concentration were not significantly different from those in plasma in the post-distribution phase. Intra-articular indoprofen may be a useful addition to the treatment of RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541165
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  • 10
    Electronic Resource
    Electronic Resource
    Increased numbers of active B cells in the circulation of patients with rheumatoid arthritis (1984)
    Springer
    Rheumatology international 4 (1984), S. 19-21 
    Details
    ISSN: 1437-160X
    Keywords: Reverse haemolytic plaque assay ; Ig secreting cells ; Rheumatoid arthritis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Increased numbers of cells secreting immunoglobulins of class G, M and A have been demonstrated in the peripheral blood of patients with active rheumatoid arthritis using the reverse haemolytic plaque assay. Lower numbers of secreting cells were detected in rheumatoid patients in spontaneous remission. Culture of the peripheral blood mononuclear cells was associated with a fall in the number of immunoglobulin secreting cells. Values for rheumatoid and normal cells did not differ significantly after 3 days of culture. The presence of an activating factor in the rheumatoid patients is postulated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00683879
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