ISSN:
0170-2041
Keywords:
(-)-Hypnophilin, enantiomerically pure
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Chemistry and Stereochemistry of Iridoids, XVI. - EPC-Synthesis of (-)-HypnophilinThe synthesis of enantiomerically pure (-)-hypnophilin (27) from (6R,7R)-(-)-7-hydroxy-3-oxabicyclo[4.3.0]non-1-en-9-one (1) is described. 1 was obtained in 93% yield from catalpol, which is readily available from the aqueous sodium carbonate extract of Picrorhiza kurrooa (Scrophulariaceae). The specific rotation, MS, 1H- and 13C-NMR data of synthetic (-)-hypnophilin were identical with those of the natural product.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1991199101154
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