ISSN:
1573-8221
Keywords:
vascular smooth muscles
;
serotonin
;
histamine
;
calcium ions
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Experiments on isolated segments of the dog internal carotid artery showed that serotonin (5-HT), in a concentration of 5·10−11 to 5·10−5 g/ml, activates contractions. Histamine in a concentration of 5·10−9 g/ml causes relaxation of the segments, but higher concentrations activate contractile responses. 5-HT and histamine were found to evoke contractile responses of depolarized vascular smooth muscle. It is suggested that 5-HT activates the inward calcium ion current through the membrane whereas histamine activates both the inflow of extracellular calcium and the outflow of calcium ions from the intracellular depots.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00804760
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