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  • 1
    Electronic Resource
    Electronic Resource
    Biological effects of trilostane in vitro on oocyte maturation and fertilization in the hamster (1984)
    Springer
    Cellular and molecular life sciences 40 (1984), S. 1214-1217 
    Details
    ISSN: 1420-9071
    Keywords: Hamster oocytes ; oocytes ; hamster ; trilostane ; oocyte fertilization in vitro ; oocyte maturation in vitro ; steroidogenesis ; pronuclear formation ; polyspermy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effects of the inhibition of steroidogenesis by trilostane on oocyte maturation were examined by studying spontaneous maturation and fertilization in vitro. 10−6 M trilostane had no influence on the meiotic process, whether the oocytes were naked or not. At a concentration of 10−6 M and 10−7 M trilostane, low normal pronuclear formation and high polyspermy were found during in vitro fertilization. However, no retarded male pronuclear development could be detected in the trilostane-treated group. Thus, steroid producing activity within ova is apparently necessary to prevent multiple sperm penetration, but it has no effect on meiosis or the action of the so-called male pronucleus growth factor (MPGF).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01946649
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  • 2
    Electronic Resource
    Electronic Resource
    Riesenzell-Pseudokalk-Nekrosen im Frühstadium arteriosklerotisch verschlußbedingter Rindennekrosen (1973)
    Springer
    Acta neuropathologica 23 (1973), S. 313-319 
    Details
    ISSN: 1432-0533
    Keywords: Pseudo-Calcium ; Colliquation Necrosis ; Giant Cell Proliferation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of extensive giant cell proliferation in association with abundant pseudocalcium deposits in a colliquation necrosis is reported. Neuropathological and ultrastructural findings are demonstrated, the pathogenetic factors are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687460
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  • 3
    Electronic Resource
    Electronic Resource
    Striatonigral degeneration combined with Alzheimer's disease (1981)
    Springer
    Acta neuropathologica 54 (1981), S. 253-256 
    Details
    ISSN: 1432-0533
    Keywords: Striatonigral degeneration ; Alzheimer's disease ; Parkonsonism ; Dementia ; Tyrosine hydroxylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case with clinical features of progressive parkinsonism and dementia of presenile occurrence was characterized by the following neuropathologic findings: (1) severe degeneration in the striationigral system and (2) widespread occurrence of numerous senile plaques and Alzheimer's neurofibrillary tangles in the cerebral cortex. We believe this to be a very rare case of striatonigral degeneration combined with Alzheimer's disease, because, as far as we know, only two similar cases have been reported and they had not such typical characteristics of Alzheimer's disease as ours did. In addition, in our case the biochemical examination revealed that the activity of one of the dopamine-synthesizing enzymes, tyrosine hydroxylase, was greatly decreased in the nigro-striato-pallidal system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687749
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  • 4
    Electronic Resource
    Electronic Resource
    Generalisierte zentrale Neurofibromatosen und ihre singulären formes frustes (1971)
    Springer
    Acta neuropathologica 18 (1971), S. 160-172 
    Details
    ISSN: 1432-0533
    Keywords: Neurofibromatosis ; Central Dysgenesia ; Glial Glioblastosis ; Diffuse Dysmyelination ; Glioma Opticum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The case of a 14-month-old boy afflicted with central neurofibrobromatosis is presented which included the following dysgenetic disorders: glioma of the optic nerve; diffuse cellular and fibrillar gliosis with deficient myelinization; subpial, subendymal and perivascular fibrillar gliosis with hypermyelinization; diffuse cellular and fibrillar gliosis in the cortex mainly of the limbic system and the paleocerebellum; ectopic subarachnoid glia; paraendymal spongioblast nodules and a single blastomatous glial nest. The diffuse dysgenetic gliosis did not appear to be blastomatous, and thus it cannot be compared with diffuse glioblastomatosis. The question of special dysgenetic disturbances of myelinization—with respect both to retarded and to paradox myelinization—is discussed in relation to findings made in recent electron microscopic studies and animal experiments. Bielschowsky's term: glial dysgenesia with blastomatosis, (Gliadysgenesien mit blastomatösem Einschlag) applies to tuberous sclerosis and central neurofibromatosis as well as to a very large group of singular, unifocal lesions for which only relatively rarely genetic connections with the two principal groups, i.e. Reckling-hausen's and Bourneville's disease, can be found. Epileptogenic, tumor-like, “paratumoral”, dysgenetic uncus gliosis and dysgenetic aqueduct stenosis for example, should be included here.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687604
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  • 5
    Electronic Resource
    Electronic Resource
    Virusähnliche Filamente und kristalloide Einschlüsse bei einem Fall von “primärer” Reticuloendotheliose des Gehirns (1972)
    Springer
    Acta neuropathologica 21 (1972), S. 39-49 
    Details
    ISSN: 1432-0533
    Keywords: Neuroreticulosis ; “Virus-like” Structure ; Crystalline Structures ; Myxo-viruses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 57 year old male complained of tiredness, apathy, dysarthria, unsteadiness of gait. The symptoms became more and more severe. Temperatures of 39° C (102.2° F) appeared and the patient died after 4 months illness. At autopsy pulmonary embolism was found. The neuropathological examination revealed changes typical of neuroreticulosis, such as tumor-like proliferation of reticulum cells in the medio-basal parts of the brain with abundant formation of reticulin fibres and diffuse astro- and microglial proliferations also in the cerebral cortex with perivascular cuffs. Electron microscopic study performed after 9 months of formalin-fixation of the tissue showed: 1. “virus-like”-filamentous structures in the cytoplasm of proliferated reticular cells near the vascular wall, which had an outside diameter of about 140–150 Å, and a length of 2300 Å. 2. peculiar distribution of nucleoprotein in the proliferative cells, such as filamentous or net-like structures of about 160 Å outside diameter. 3. intraplasmatic and nuclear crystalline structures of oblong rhombic shape with differentiated dark and bright stripes with a periodicity of 300–350 Å. There is some possibility that mixoviruses may play an aetiological role in neuroreticulosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687998
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  • 6
    Electronic Resource
    Electronic Resource
    Morphological and biochemical changes in the cholinergic and monoaminergic systems in Alzheimer-type dementia (1986)
    Springer
    Acta neuropathologica 70 (1986), S. 112-116 
    Details
    ISSN: 1432-0533
    Keywords: Alzheimer-type dementia ; Cytometry ; Cholinergic system ; Monoaminergic system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The integrity of cholinergic and monoaminergic neuronal systems in Alzheimer-type dementia (ATD) was studied using a combination of morphological and biochemical procedures applied to samples from seven ATD brains and ten control brains. On morphological examination, the number of neurons was counted in the nucleus basalis of Meynert (nbM), the locus coeruleus (LC) and the nucleus centralis superior (NCS). Biochemically, the activities of choline acetyltransferase (ChAT) and the concentrations of noradrenaline (NA) and serotonin (5-hydroxytryptamine; 5-HT) were measured in the nbM, LC, NCS, frontal cortex, temporal cortex and occipital cortex. Compared with the controls, the mean number of neurons in the nbM and LC were significantly reduced in the ATD brains. The neuronal loss in the NCS in the ATD brains was not significant. The ChAT activities in all regions from the ATD brains had a tendency to be reduced. Marked reductions in the NA concentrations in the LC and 5-HT concentrations in the temporal and occipital cortices were found in the ATD brains. These findings suggest that various neurotransmitter systems, including cholinergic, noradrenergic and serotonergic systems, are affected in the ATD brains.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691428
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  • 7
    Electronic Resource
    Electronic Resource
    Maturation of human ovarian follicular oocytes in vitro (1970)
    Springer
    Cellular and molecular life sciences 26 (1970), S. 640-642 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Des ∄ufs oocytes humains obtenus des follicules d'ovaire extraits opérativement ont été cultivés in vitro pour étudier le processus de leur maturation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01898736
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  • 8
    Electronic Resource
    Electronic Resource
    Menstrual cycle-associated alteration of sulfogalactosylceramide in human uterine endometrium: Possible induction of glycolipid sulfation by sex steroid hormones
    Amsterdam : Elsevier
    Archives of Biochemistry and Biophysics 268 (1989), S. 129-136 
    Details
    ISSN: 0003-9861
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-9861(89)90573-0
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  • 9
    Electronic Resource
    Electronic Resource
    An Amber Mutation of Prion Protein in Gerstmann-Straussler Syndrome with Mutant PrP Plaques
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 192 (1993), S. 525-531 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1006/bbrc.1993.1447
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  • 10
    Electronic Resource
    Electronic Resource
    Diplococcal β-galactosidase with a specificity reacting to β1-4 linkage but not to β1-3 linkage as a useful exoglycosidase for the structural elucidation of glycolipids
    Amsterdam : Elsevier
    Analytical Biochemistry 165 (1987), S. 465-469 
    Details
    ISSN: 0003-2697
    Keywords: carbohydrate linkage ; detergents ; glycolipids ; hydrolase ; sequencing
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0003-2697(87)90297-1
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