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  • 1
    Electronic Resource
    Electronic Resource
    Additions and Corrections - Organoboron Compounds in Organic Synthesis. 1. Asymmetric Hydroboration. (1985)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 107 (1985), S. 5832-5832 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00306a604
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  • 2
    Electronic Resource
    Electronic Resource
    Topology-Oriented Implementation—An Approach to Robust Geometric Algorithms (2000)
    Springer
    Algorithmica 27 (2000), S. 5-20 
    Details
    ISSN: 1432-0541
    Keywords: Key words. Clipping a convex polyhedron, Line-segment Voronoi diagram, Robust implementation, Topological consistency.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract. This paper presents an approach, called the ``topology-oriented approach,'' to numerically robust geometric algorithms. In this approach, the basic part of the algorithm is described in terms of combinatorial and topological computation primarily; this description guarantees robustness of the algorithm because combinatorial and topological computation is never contaminated with numerical errors. However, this part of the algorithm is usually nondeterministic, the flow of processing containing many alternative branches. Hence, numerical computation is used in order to choose the branch that seems the most promising to lead to the correct answer. The algorithm designed in this way is robust and simple. The basic idea of this approach as well as the basic properties of the resulting algorithms is shown with examples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004530010002
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  • 3
    Electronic Resource
    Electronic Resource
    An adult-onset case of sporadic motor neuron disease with basophilic inclusions (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 660-665 
    Details
    ISSN: 1432-0533
    Keywords: Juvenile amyotrophic lateral sclerosis ; Neurofibrillary tangles ; Putamen ; Motor cortex ; Motor neuron disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 36-year-old man developed motor neuron signs consisting of weakness and atrophy of the right upper limb, which progressed to involve the other limbs along with development of upper motor neuron signs including pseudobulbar palsy. He died 8.5 years after onset. Bilateral precentral gyri and putamina were grossly atrophic. In addition to severe degeneration of bilateral pyramidal tracts and marked neuronal cell loss of the precentral gyri and putamina, basophilic inclusions were widely distributed in the motor cortex, putamina, general somatic motor neurons such as the hypoglossal nucleus and spinal anterior horns, and other areas like the red nucleus and inferior olive. The inclusions were clearly shown with Nissl stain to be anilinophilic irregular masses with distinct rims. Ultrastructurally the inclusions appeared to consist of thick filamentous structures of 12–25 nm in diameter studded with electron-dense ribosomelike granules. Thick filamentous profiles were relatively short or occasionally fragmentary, haphazardly mingled with various amounts of granules and other organelles. No prominent accumulation of 10-nm neurofilaments or eosinophilic inclusions like Bunina bodies were found. The inclusions were indistinguishable from those reported in so-called “juvenile” amyotrophic lateral sclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00307636
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  • 4
    Electronic Resource
    Electronic Resource
    Brain lesions of the Leigh-type distribution associated with a mitochondriopathy of Pearson's syndrome: Light and electron microscopic study (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 337-341 
    Details
    ISSN: 1432-0533
    Keywords: Pearson's syndrome ; Leigh's disease ; Mitochondrial disease ; Mitochondriopathy ; Mitochondrial encephalomyopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pearson's syndrome is a disease of refractory sideroblastic anemia and exocrine pancreatic dysfunction due to abnormal mitochondrial DNA (mtDNA). A male infant with Pearson's syndrome developed necrosis of both thalami and basal ganglia when he suffered from gastroenteritis at 1 year and 11 months of age. He died of sepsis at the age of 2 years and 4 months. Analysis of mtDNA from various organs revealed abnormal mtDNA with deletion by 5 kbp, confirming the diagnosis. At autopsy, the brain had symmetrical cavities in putamen, caudate nuclei and medial nuclei of the thalami. Ferruginous granules in nerve cells in medial thalamic nuclei, and scattered round bodies with neuronophagia in lateral nuclei were found at light microscopic observation. Electron microscopy showed that these granules were composed of radiating spicules and a dense layer containing packed cytoplasmic organelles, respectively. The macroscopic distribution of brain lesions was very similar to and characteristic of Leigh's disease. This similarity leads to the supposition that defective intracellular energy utilization common to Leigh's disease could be responsible for brain lesions in this case. Although the histological appearance was somewhat atypical for Leigh's disease, very acute formation of brain lesions in this case was thought to have caused the histological difference.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227830
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  • 5
    Electronic Resource
    Electronic Resource
    Myelination of two axons by a single Schwann cell (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 574-576 
    Details
    ISSN: 1432-0533
    Keywords: Aberrant myelination ; Axon ; Myelination ; Schwann cell
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A Schwann cell can form only one internode of myelin around an axon. However, we observed the formation by a single Schwann cell of myelin around two axons of different diameters in the sural nerve of a 45-year-old man with mononeuritis multiplex. Schwann cell processes spiraled in the same direction around each axon, forming mesaxons. The findings in this case appear to be an undescribed type of aberrant myelination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304478
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  • 6
    Electronic Resource
    Electronic Resource
    Ultrastructural study of chromatolytic neurons in an adult-onset sporadic case of amyotrophic lateral sclerosis (1988)
    Springer
    Acta neuropathologica 75 (1988), S. 523-528 
    Details
    ISSN: 1432-0533
    Keywords: Amyotrophic lateral sclerosis ; Chromatolysis ; Ultrastructure ; Motor neuron disease ; Hyaline intraneuronal inclusions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ultrastructural features of chromatolytic neurons observed in a sporadic case with amyotrophic lateral sclerosis (ALS) are reported. A 70-year-old woman died of weakness and atrophy of the four limbs, bulbar and facial muscles, and hyperreflexia, of 3 1/2 years' duration. Neuronal loss was marked in the anterior horn of the spinal cord, with degeneration of the pyramidal tracts. Most of the remaining neurons showed chromatolysis. Some of the chromatolytic neurons contained faintly eosinophilic inclusions with a halo. Few spheroids were observed. Hypoglossal nuclei, nucleus ambiguus, motor nuclei of N. VII and N.V were well populated, but contained several chromatolytic neurons. Ultrastructurally, the chromatolytic neurons contained aggregates of fibrils thicker than the 10-nm neurofilaments. These fibrils were arranged randomly, and were closely associated with granular materials as well as rough endoplasmic reticulum. Neurofilamentous accumulations reported to be common in sporadic ALS were rare in this case. No Bunina body was observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687142
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  • 7
    Electronic Resource
    Electronic Resource
    Adult-type citrullinemia (1989)
    Springer
    Acta neuropathologica 78 (1989), S. 96-100 
    Details
    ISSN: 1432-0533
    Keywords: Citrullinemia ; Pseudoulegyric-type hepatocerebral disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An autopsy case of adult-type citrullinemia in a 42-year-old male is reported. The patient neuropathologically presented mixed cerebral changes consisting of the pseudoulegyric and ischemic types of hepatocerebral disease. In common with previously reported cases of the pseudoulegyric type, the nature and localization of the cerebral changes in this case were characteristic, in that neuronal loss occurred most severely and symmetrically in the mediobasal part of the frontal and occipital lobes, gyrus cinguli, claustrum, insula and temporal lobe, and that the watershed area of the cerebral cortex, basal ganglia and Purkinje cells were only slightly affected. The importance of hypercitrullinemia was stressed in the pathogenesis of the cerebral changes evident in adulttype citrullinemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00687408
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  • 8
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of flosequinan in elderly patients with chronic congestive heart failure (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 387-389 
    Details
    ISSN: 1432-1041
    Keywords: Flosequinan ; Congestive heart failure ; elderly ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have investigated the pharmacokinetics of the direct vasodilator flosequinan in elderly patients with congestive heart failure. Eight patients received a single dose of 50 mg, and 8 patients received once-daily treatment with 25 mg for two weeks. In the single dose study, the tmax of flosequinan was 2.5 h, Cmax was 1.17 μg · ml−1 and t1/2 was 5.63 h. The tmax of the metabolite BTS 53554 was 20.3 h, Cmax was 1.44 μg · ml−1 and t1/2 was 62.0 h. BTS 53554 accumulated gradually in the 14-day repeated dose study and steady-state was reached after approximately 2 weeks. Flosequinan was not found to accumulate. Adverse reactions were not observed in either the single or repeated dose study. It is advisable to consider renal function and body weight when flosequinan is to be administered to elderly patients with congestive heart failure. The initial dose should be 25 mg.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316479
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  • 9
    Electronic Resource
    Electronic Resource
    Partition Distribution of Aroma Volatiles from Orange Juice into Selected Polymeric Sealant Films (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 55 (1990), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The sorption of organic volatiles from orange juice by polymeric food contact materials was investigated. Three sealant films were evaluated, a commercial low density polyethylene and two developmental films, an ethylene vinyl alcohol copolymer of high ethylene content and a co-polyester. Samples of the films were immersed in the juice for 24 days at 22°C and the level of sorbed volatiles monitored as a function of time. Three probe compounds (d-limonene, neral and geranial) were selected as being representative of orange juice flavor components. A gas chromatographic technique was developed to quantify the level of probe compounds in juice and films. Results compared favorably to the more traditional bromide-bromate titration method. Sorption of organic volatiles by one of the developmental films (co-polyester) was significantly lower than the others.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1990.tb06041.x
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  • 10
    Electronic Resource
    Electronic Resource
    Adsorption of Methyl Orange on Starches (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 56 (1991), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Adsorption characteristics of methyl orange were investigated on kudzu, sweet potato, corn, rice, wheat, potato and snake gourd starches. No adsorption of methyl orange, an anionic dye, was observed on potato starch and snake gourd starch because of the presence of phosphate esters. Adsorption isotherms were found to fit both the Langmuir equation and Freundlich equation in all others. The degree of adsorption by kudzu, sweet potato, corn and wheat starches was related to the number of hydroxyl groups. We suggested methyl orange was confined to a monolayer on surface hydroxyl groups of the starches.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1991.tb07982.x
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