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  • 1
    Electronic Resource
    Electronic Resource
    Latent herpes simplex virus type 1 in human geniculate ganglia (1992)
    Springer
    Acta neuropathologica 84 (1992), S. 39-44 
    Details
    ISSN: 1432-0533
    Keywords: Herpes simplex virus ; Latent infection ; Human geniculate ganglion ; In situ hybridization ; Bell's palsy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Viral infection, especially by reactivation of herpes simplex virus (HSV) has been considered to be a possible explanation for the pathogenesis of idiopathic peripheral facial nerve palsy (Bell's palsy). We investigated whether the geniculate ganglia of man contain latent HSV type 1 (HSV-1), and compared the frequency of HSV-infected ganglia and that of latently infected neurons in human geniculate ganglia and in trigeminal ganglia. From autopsy specimens of eight adults 15 geniculate ganglia and 16 trigeminal ganglia were examined by means of in situ hybridization and immunohistochemical staining. The HSV-1 genome was detected in 11 of the 15 (71%) geniculate ganglia and in 13 of the 16 (81%) trigeminal ganglia. No HSV antigen was noted in any of the ganglia. The incidence of latently infected neurons was 0.9% in the trigeminal ganglia and 5.3% in the geniculate ganglia. The difference in percentages between the two types of ganglia was significant. Our results suggest that reactivation of latent HSV in the geniculate ganglia is a probable cause of some cases of herpetic stomatitis and of idiopathic peripheral facial nerve palsy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427213
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  • 2
    Electronic Resource
    Electronic Resource
    Jun and Fos related gene products bind to and modulate the GPE I, a strong enhancer element of the rat glutathione transferase P gene
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Gene Structure and Expression 1219 (1994), S. 499-504 
    Details
    ISSN: 0167-4781
    Keywords: (Rat) ; DNA binding activity ; GPE I ; Glutathione transferase P gene ; Jun and Fos related gene product ; Transcriptional regulation
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0167-4781(94)90077-9
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    The three-dimensional fibrillar arrangement of the basilar membrane in the mouse cochlea (1995)
    Springer
    European archives of oto-rhino-laryngology and head & neck 252 (1995), S. 495-498 
    Details
    ISSN: 1434-4726
    Keywords: Cochlea ; Scanning electron microscopy ; Basilar membrane ; Mouse ; Sodium hydroxide tissue maceration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The three-dimensional fibrillar arrangement of the basilar membrane in the mouse cochlea was studied using scanning electron microscopy. Fibrils of the basilar membrane were exposed by removing cellular elements of the cochlea using a sodium hydroxide maceration technique. The arrangement of fibrils in the basilar membrane was different between the pars arcuata and pars pectinata. In the pars arcuata, fibrils were arranged in radial and spiral direction, showing a woven pattern. In the pars pectinata, most of the fibrils ran in the radial direction. These findings suggest that the vibration pattern of the pars arcuata and pars pectinata is different when the basilar membrane vibrates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02114759
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    Paper (German National Licenses)
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