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  • 1
    Electronic Resource
    Electronic Resource
    Photolysis of carbonyl ylides. Double-irradiation studies (1976)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 98 (1976), S. 5697-5699 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00434a050
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  • 2
    Electronic Resource
    Electronic Resource
    Glycosylated haemoglobin in renal failure (1981)
    Springer
    Diabetologia 21 (1981), S. 163-163 
    Details
    ISSN: 1432-0428
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00251288
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of conventionalization on cecal wall structure of germ-free Wistar rats: quantitative light and qualitative electron microscopic observations (1989)
    Springer
    Anatomy and embryology 180 (1989), S. 191-198 
    Details
    ISSN: 1432-0568
    Keywords: Cecum ; Germ-free rat ; Microflora inoculation ; Morphometry ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The structural changes of the cecal wall in germfree rats were observed at regular intervals after the inoculation of fecal microflora from conventional rats. Quantitative light microscopy showed that most of the elements in the cecal wall increased at 12 or 24 h and reached peak values at 4 days after inoculation. On the 7th day, they decreased approximately to the values for conventional rats. The crypts were bent or widely open till 24 h but were not after the 4th day. Hyperplasia of the crypt epithelial cells including mucous-type cells was observed following microbial inoculation. Electron microscopy revealed that most of the epithelial cells lining the mucosa were typical columnar cells. Desquamation of the epithelial cells and contraction of the muscle fibers were often seen on 4th day. The mucous-type cells were divided into two types, goblet and non-goblet mucous-type cells. Reduction of cecal volume after microbial inoculation may be mainly caused by muscle contraction in the early period and hyperplasia and desquamation of the epithelial cells may suggest their role as the first and non-specific defense line prior to operation of the specific immune system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309771
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  • 4
    Electronic Resource
    Electronic Resource
    Morphological Purkinje cell changes in spinocerebellar ataxia type 6 (2000)
    Springer
    Acta neuropathologica 100 (2000), S. 371-376 
    Details
    ISSN: 1432-0533
    Keywords: Key words SCA6 ; Purkinje cell ; Immunohistochemisry ; Calbindin-D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Spinocerebellar ataxia type 6 (SCA6) was recently identified as a form of autosomal dominant spinocerebellar ataxia associated with a small CAG repeat expansion of the gene encoding an α 1 A-voltage-dependent calcium channel gene subunit on chromosome 19p13. In this study 50-μm-thick sections of cerebellar tissue from one patient with SCA6 were subjected to free-floating immunohistochemical staining with calbindin-D and parvalbumin antibodies. Severe loss of Purkinje cells was found, particularly in the vermis, and various morphological changes in Purkinje cells and their dendritic arborizations were demonstrated. Many of the remaining Purkinje cells were found to have heterotopic, irregularly shaped nuclei, an unclear cytoplasmic membrane outline, and somatic sprouts. Increased numbers of spine-like protrusions from swelling dendritic arborizations were found in the molecular layer. The axonal arrangement was disordered, and many torpedos were found in the granular layer and white matters. These morphological changes are completely different from those observed in paraneoplastic cerebellar degeneration (PCD) and multiple system atrophy (MSA) and are considered to be related to the genetic abnormality that causes abnormal development of Purkinje cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010000201
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  • 5
    Electronic Resource
    Electronic Resource
    Increased fructose-lysine of nail protein in diabetic patients (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 477-478 
    Details
    ISSN: 1432-1440
    Keywords: Fructose-lysine ; Furosine ; Haemoglobin A1 ; Glycosylation ; Diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fructose-lysine, which is formed by binding glucose to lysine, is degraded on acid hydrolysis into furosine. Furosine was determined by high-performance liquid chromatography according to the method of Schleicher et al. Furosine values were significantly higher in diabetic patients than in healthy subjects, and significantly correlated with haemoglobin A1 (HbA1) values. These results suggest that furosine, like HbA1, may become an indicator of long-term blood glucose control in diabetic patients and be useful in investigating diabetic complications on the level of tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726910
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  • 6
    Electronic Resource
    Electronic Resource
    Increased fructose-lysine of hair protein in diabetic patients (1985)
    Springer
    Journal of molecular medicine 63 (1985), S. 728-730 
    Details
    ISSN: 1432-1440
    Keywords: Fructose-lysine ; Furosine ; Haemoglobin A1 ; Glycosylation ; Diabetes mellitus ; Hair
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Fructose-lysine, which is formed by binding glucose to lysine, is changed by acid hydrolysis into furosine. Furosine derived from fructose-lysine of hair was determined by high-performance liquid chromatography according to the method of Schleicher et al. Furosine values were significantly higher in diabetic patients than in healthy subjects, and significantly correlated with the stable components of hemoglobin A1 (HbA1) values. These results suggest that furosine, like HbA1, may become an indicator of past blood glucose control at any time in diabetic patients and be useful in investigating diabetic complications on the level of tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01733118
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  • 7
    Electronic Resource
    Electronic Resource
    Relationship between bottom characteristics and benthic organisms in the shallow water of Oppa Bay, Miyagi (1989)
    Springer
    Marine biology 102 (1989), S. 265-273 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract An investigation was conducted to examine the species composition, abundance and biomass of benthic macrofaunal invertebrates in Oppa Bay, Miyagi Prefecture, Japan, in August 1984. Among 212 species identified, nearly half (105) were Polychaetes. Usually five species, Ampharete sp. 1, Neosabellides sp. 1, Nephtys polybranchia, Chaetozone sp. 1, and Lumbrineris longifolia were numerically dominant. The faunal features of dominant species were clearly divided into two areas using two indicator species, Amphalete sp. 1 and Neosabellides sp. 1. The former species decreased in numbers in the area from the river to the bay mouth, while the latter increased. Sediments consisted of sand at the river mouth and in the northern bay; and of silt-clay in the central bay, bay mouth and southern part of the bay. Gradients of species diversity (H′) were expressed as a function of distance by linear regression. The relationship was positive (r=0.812) from the river to the bay mouth accompanied by increasing depth; and negative (r=-0.906) from northern to southern parts of the bay in proportion to the increase of silt-clay in sediments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428288
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  • 8
    Electronic Resource
    Electronic Resource
    Actions of afferent impulses from muscle receptors on cerebellar purkyně cells I. Responses to muscle vibration (1972)
    Springer
    Experimental brain research 15 (1972), S. 177-193 
    Details
    ISSN: 1432-1106
    Keywords: Cerebellum ; Purkyně cell ; Muscle afferent fibres
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Investigations were made in the decerebrate cat of the effect of muscle vibration on the activity of 342 Purkyně cells in the ipsilateral anterior lobe of the cerebellum. The effects were studied for three different muscle groups: in the hindlimb, the anterior tibial group (extensor digitorum longus, peroneus longus, brevis and tertius, and tibialis anterior) and gastrocnemius-soleus; and in the forelimb, the extensor digitorum lateralis and communis muscles. The responses of Purkyně cells were mediated by both the mossy fibre and climbing fibre inputs. The mossy fibre induced responses were generally inhibitory and had latencies only a few msec longer than responses evoked by stimulation of the nerve supplying the muscle. In contrast, the latencies of responses mediated by the climbing fibres were long and variable. Nine cells out of 342 Purkyně cells showed weak response to vibration of less than 60 μ amplitude, as compared to approximately 40% of those which responded to vibration of above 60 μ up to 200 μ amplitude, indicating the preponderant action of Group II afferents on the Purkyně cells in contrast to far less influence from Group Ia afferents. There was no obvious difference in threshold of vibration amplitude regarding the response mediated by the climbing or mossy fibres. Purkyně cell responses mediated by both mossy and climbing fibre inputs displayed temporal summation in response to muscle vibration, although no tonic effects were observed in response to maintained periods (1–5 sec) of vibration. Purkyně cell responses evoked by the mossy fibre input were unable to follow the individual cycles of vibration at frequencies above approximately 50 cps. Those evoked by the climbing fibres could follow at frequencies of less than 10 cps.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00235581
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  • 9
    Electronic Resource
    Electronic Resource
    Actions of afferent impulses from muscle receptors on cerebellar Purkyně cells. II. Responses to muscle contraction: Effects mediated via the climbing fiber pathway (1972)
    Springer
    Experimental brain research 16 (1972), S. 104-114 
    Details
    ISSN: 1432-1106
    Keywords: Cerebellum ; Purkyně cell ; Climbing fibers ; Muscle afferent fibres
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of isometric contraction of the gastrocnemius-soleus muscle group was investigated on the responses of 79 cerebellar Purkyně cells (P-cells) in the decerebrate cat. Forty three percent of the P-cells tested were responsive to contraction via a pathway that acted by way of climbing fibres. The latency of these responses was long (mean 60 msec following ventral root stimulation) and variable. It was concluded that the responses were attributable to Group Ib afferent input. An excitatory action of the contraction on spindle afferent fibres was excluded because the responses were: a) evoked by submaximal contractions produced by weak single shock stimulation of the ventral root; b) negligible following isotonic contractions; and, c) augmented when a stretch was superimposed on the rising phase of the twitch. The effects of both muscle contraction and muscle vibration were studied for many of the P-cells in order to investigate the convergence from afferents of both spindle and tendon organ origin. Few P-cells had evidence of a convergent input from Group Ia, II, and Ib fibres. In contrast convergence from Group II and Group Ib input was quite common. With some cells, there appeared to be an input from only Group Ib or Group II fibres.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00233377
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  • 10
    Electronic Resource
    Electronic Resource
    Acycloguanosine therapy of the localized form of herpes simplex virus infection in a low-birth-weight infant (1983)
    Springer
    European journal of pediatrics 141 (1983), S. 113-114 
    Details
    ISSN: 1432-1076
    Keywords: Antiviral agents ; Herpes genitalis ; Herpes simplex ; Herpes virus infections
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It is known that the localized form of herpes simplex virus (HSV) infection does not always show a good prognosis. A preterm infant who evidenced skin and tongue lesions, caused by HSV type 1, was treated by acycloguanosine. The results was satisfactory without any complications. Therefore, a localized form of HSV infection of the newborn infant, even though the patient has a low-birth-weight, should be treated by the drug immediately after the observation of the positive HSV culture.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00496801
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    Paper (German National Licenses)
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