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  • 1
    ISSN: 1432-0428
    Keywords: Keywords Type II diabetes mellitus ; extracellular matrix ; glomerulosclerosis ; type IV collagen ; Otsuka-Long-Evans-Tokushima-Fatty rat.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Advanced glycation end products (AGEs) participate in the pathogenesis of diabetic nephropathy. We reported earlier that OPB-9195, a synthetic thiazolidine derivative and novel inhibitor of advanced glycation, prevented progression of diabetic glomerulosclerosis by lowering serum concentrations of advanced glycation end products and reducing their deposition in the glomeruli. Here, we examined their contribution and that of growth factors, such as transforming growth factor-β (TGF-β) and vascular endothelial growth factor (VEGF), to the progression of diabetic nephropathy. We also investigated the expression of type IV collagen in the kidneys of Otsuka-Long-Evans-Tokushima-Fatty (OLETF) rats, a Type II (non-insulin-dependent) diabetes mellitus model, after treatment with OPB-9195. Methods. Using northern blots and immunohistochemical techniques, we determined the renal expression of TGF-β and type IV collagen mRNAs and proteins in OLETF rats. We also examined OPB-9195's effects on renal expression of VEGF mRNA and protein. Results. Concomitant increases in TGF-β and type IV collagen expression were observed at each point in time in OLETF rats not given OPB-9195. In contrast, OPB-9195 treatment greatly suppressed the renal expression of TGF-β, VEGF and type IV collagen mRNAs and proteins to that seen in non-diabetic rats. Conclusion/interpretation. Since OPB-9195, an AGE-inhibitor, prevented the progression of diabetic nephropathy by blocking type IV collagen production and suppressing overproduction of two growth factors, TGF-β and VEGF, in diabetic rats, this compound warrants further investigation. [Diabetologia (1999) 42: 579–588]
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Mit elektromagnetischen Strömungsmessern wurde der Blutdurchfluß während akuter intrakranieller Drucksteigerung in den freigelegten Aa. carotides und vertebrales von Affen gemessen. Gleichzeitig wurden die Druckwerte in den einzelnen Schädelhöhlen, Blutdruck, CO2-Konzentration in der Atmungsluft und Atembewegungen registriert. Ein lokalisierter raumfordernder Prozeß führt zu verschiedenen Druckwerten in den einzelnen intrakraniellen Abschnitten. Während der Aufblähung eines supratentoriellen Ballons besteht in der Regel ein Druckgefälle im Subduralraum von der ipsi- zur kontralateralen Großhirnhemisphäre und vom supra- zum infratentoriellen Raum, während bei einem infratentoriellen raumfordernden Prozeß der Druck über beiden Großhirnhemisphären gleichmäßiger ansteigt. Entsprechend den verschiedenen arteriovenösen Druckdifferenzen in den einzelnen Hirnabschnitten ist auch der Blutdruckfluß in den großen Hirnarterien verschienden. Die arteriovenösen Druckdifferenzen werden durch Lage und Ausdehnung des raumfordernden Prozesses mitbeeinflußt. Durch eine Verlagerung der Hirnsubstanz wird eine zusätzliche Drosselung der Hirndurchblutung infolge Abklemmung von Brückenvenen verursacht, die bei gleichmäßiger Druckerhöhung ohne Massenverschiebung weniger ins Gewicht fällt. Die experimentellen Resultate deuten darauf hin, daß die für die Größe der Hirndurchblutung wichtige Blutdruckerhöhung während akuter Hirndrucksteigerung eher eine Folge axialer Hirnstammtorsionen als einer allgemeinen Ischämie im infratentoriellen Raum ist. Außerdem spielen Stoffwechselfaktoren, namentlich die Anreicherung von CO2 während Atemstörungen, eine Rolle. Die Hirndurchblutung während akuter intrakranieller Drucksteigerungen durch einen lokalisierten raumfordernden Prozeß wird deshalb nicht durch einen einzelnen Faktor allein, sondern durch das Zusammenspiel verschiedener anatomischer, hämodynamischer und metabolischer Faktoren bestimmt. Bei fehlender Massenverschiebung ist die Korrelation zwischen Blutdruck, resp. arteriovenöser Druckdifferenz und Hirndurchblutung deshalb wesentlich besser als beim Vorliegen von Massenverschiebungen.
    Abstract: Résumé On a mesuré le flux sanguin lors d'une augmentation aiguë de la tension intracrânienne au moyen d'un appareil électromagnétique (flow meter) dans les carotides et artères vertébrales de singes. Simultanément on a enregistré les tensions dans les différentes cavités crâniennes, la tension artérielle, la concentration du CO2 dans l'air respiré et les mouvements respiratoires. Lors du gonflement d'un ballon supratentoriel on trouve en général une chute de tension dans l'espace sous-dural entre l'hémisphère ipsilatérale et la contralatérale, ou entre l'espace supra-tentoriel et infratentoriel. Un processus infratentoriel augmente la tension au-dessus des deux hémisphères d'une façon plus régulière. La variation du flux sanguin dans les grandes artères cérébrales correspond aux différentes variations de tension artérioveineuses. Celles-ci sont entre autre influencées par la localisation et l'ampleur de la tumeur. Un déplacement de substance cérébrale accentue la diminution du flux sanguin par un rétrécissement des veines cérébrales. Ce phénomène est moins net lors d'une augmentation régulière de la tension sans déplacement de masse cérébrale. Les résultats des expériences démontrent les faits suivants: s'il y a une augmentation aigüe de la tension intracrânienne, la torsion axiale du tronc cérébral est bien importante pour l'élévation de la tension artérielle (déterminant le flux sanguin), qu'une ischémie générale de l'espace infratentoriel. Des facteurs métaboliques, surtout l'augmentation du CO2 lors de troubles respiratoires, ont également une certaine influence. Dans l'accroissement aigu de la tension intracrânienne par une tumeur circonscrite, le flux sanguin cérébral n'est donc pas déterminé par un seul facteur, mais par une combinaison de différents éléments anatomiques, hémodynamiques et métaboliques. C'est pourquoi la corrélation entre tension artérielle et flux sanguin cérébral est nettement meilleure, lorsqu'il n'y a pas de déplacement de substance cérébrale.
    Notes: Conclusions and summary 1. In acute intracranial hypertension produced by localised masses in the supratentorial space, carotid and vertebral flow are influenced by complex anatomical, hemodynamic and metabolic factors. The most important factors are: the site of the mass which influences different pressure gradients, the mean blood pressure and the a-v pressure difference. The height of the intracranial pressure itself seems less important. No threshold was found for a level of intracranial pressure at which cerebral blood flow decreased. There was also no threshold for a-v pressure difference. 2. The rise in blood pressure during acute intracranial hypertension seems to be dependent on pressure gradients developed between different intracranial cavities rather than due to diffuse ischemia of the medulla. It is postulated that the factor responsible for the rise in blood pressure during intracranial hypertension is distortion of the brain stem.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: : Antihypertensive activities derived from porcine skeletal muscle proteins were investigated. Thermolysin hydrolysates of porcine muscle water-insoluble proteins demonstrated antihypertensive activities in spontaneously hypertensive rats when administrated in single oral doses. Hydrolysates of porcine myosin and peptides (Met-Asn-Pro-Pro-Lys, Ile-Thr-Thr-Asn-Pro, Met-Asn-Pro, Pro-Pro-Lys) with parts of the sequence of myosin showed antihypertensive activities. This is the first report of antihypertensive activities of peptides derived from muscle proteins of domestic animals. The hydrolysates of porcine muscle protein and their corresponding bioactive peptides might be utilized for physiologically functional foods.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 138 (1986), S. 1084-1089 
    ISSN: 0006-291X
    Keywords: [abr] HPLC; high-performance liquid chromatography ; [abr] MeIQx; 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline ; [abr] TLC; thin-layer chromatography
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 130 (1985), S. 1147-1153 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 178 (1991), S. 707-712 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 202 (1994), S. 234-240 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 194 (1993), S. 287-293 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 177 (1991), S. 840-846 
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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