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  • 1
    Electronic Resource
    Electronic Resource
    INCREASED CA2+ INFLUX IN THE RESTING STATE MAINTAIN THE MYOGENIC TONE AND ACTIVATES CHARYBDOTOXIN-SENSITIVE K+ CHANNELS IN FEMORAL ARTERIES FROM YOUNG SHR (1995)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 22 (1995), S. 0 
    Details
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. To determine the possible role of voltage-dependent Ca2+ channels (VDCC) and Ca2+-activated K+ (KCa) channels in the regulation of resting tone of arteries from young spontaneously hypertensive rats (SHR), mechanical responses to the agents which interact with these channels were examined in endothelium-denuded strips of femoral arteries from 4 week old SHR and age-matched normotensive Wistar-Kyoto (WKY) rats. Systolic blood pressures at this age were not significantly different between SHR and WKY.2. The strips from SHR, but not from WKY, maintained a myogenic tone; that is, the resting tone decreased when nifedipine was added.3. Studies using 1 or 5 min pulse labelling of the strips with 45Ca showed that the basal Ca2+ influx was increased in SHR when compared with WKY, and this increase in SHR was abolished by nifedipine. Similar results were obtained when the cytoplasmic Ca2+ concentration ([Ca2+]i) in the resting state of the strips was measured by fura-PE3.4. The addition of charybdotoxin (ChTX, a blocker of large conductance Kca channels) to the resting state caused a concentration-dependent contraction, which was much greater in SHR than in WKY. The ChTX-induced contraction in SHR was abolished by nifedipine.5. In strips preloaded with 86Rb, the basal 86Rb efflux rate constant was significantly greater in SHR than in WKY. The increase in 86Rb efflux in SHR was abolished by nifedipine.6. The results suggest that the Ca2+ influx via L-type VDCC was increased in the resting state of the femoral artery from 4 week old SHR, and therefore the myogenic tone was maintained and ChTX-sensitive K+ channels were highly activated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1440-1681.1995.tb02892.x
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  • 2
    Electronic Resource
    Electronic Resource
    Visible evidence for interparticle attraction in polymer latex dispersions (1985)
    s.l. : American Chemical Society
    Langmuir 1 (1985), S. 176-177 
    Details
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/la00061a033
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  • 3
    Electronic Resource
    Electronic Resource
    Estimation of Solubility Parameters for Some Olefin Polymers and Copolymers by Inverse Gas Chromatography (1979)
    s.l. : American Chemical Society
    Macromolecules 12 (1979), S. 1163-1167 
    Details
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ma60072a030
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  • 4
    Electronic Resource
    Electronic Resource
    On the dynamic character of "ordered" structure in polymer latex suspensions (1988)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 110 (1988), S. 6955-6963 
    Details
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ja00229a004
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  • 5
    Electronic Resource
    Electronic Resource
    Neurotransmitters partially restore glucose sensitivity of insulin and glucagon secretion from perfused streptozotocin-induced diabetic rat pancreas (1995)
    Springer
    Diabetologia 38 (1995), S. 1276-1284 
    Details
    ISSN: 1432-0428
    Keywords: Key words Acetylcholine ; norepinephrine ; insulin ; glucagon ; diabetes mellitus.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To elucidate the mechanisms of insensitivity of hormone secretion to glucose in streptozotocin-induced diabetic rat islets, we investigated the effects of acetylcholine (ACh) and norepinephrine on insulin and glucagon secretion in response to changes in glucose concentration, using perfused pancreas preparations. Basal insulin secretion at a blood glucose level of 5.6 mmol/l was significantly higher and basal glucagon secretion significantly lower in streptozotocin-induced diabetic rats than in controls, and neither high (16.7 mmol/l) nor low (1.4 mmol/l) blood glucose concentrations influenced insulin or glucagon secretion. Addition of 10−6 mol/l ACh to the perfusate increased glucose-stimulated insulin secretion. Also, 10−6 mol/l ACh, 10−7 mol/l norepinephrine, as well as a combination of both, induced marked glucagon secretion, this was suppressed by high blood glucose level. Although simultaneous addition of 10−6 mol/l ACh and 10−7 mol/l norepinephrine induced only a slight increase in glucagon secretion in response to glucopenia, there was a significant increase in glucagon secretion in conjunction with an ambient decrease in insulin. Histopathological examination revealed a marked decline in acetylcholinesterase and monoamine-oxidase activities in the islets of streptozotocin-induced diabetic rats. We speculate that reduction of the potentiating effects of ACh and norepinephrine lessens glucose sensitivity of islet beta and alpha cells in this rat model of diabetes. [Diabetologia (1995) 38: 1276–1284]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401759
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  • 6
    Electronic Resource
    Electronic Resource
    Neurotransmitters partially restore glucose sensitivity of insulin and glucagon secretion from perfused streptozotocin-induced diabetic rat pancreas (1995)
    Springer
    Diabetologia 38 (1995), S. 1276-1284 
    Details
    ISSN: 1432-0428
    Keywords: Acetylcholine ; norepinephrine ; insulin ; glucagon ; diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To elucidate the mechanisms of insensitivity of hormone secretion to glucose in streptozotocin-induced diabetic rat islets, we investigated the effects of acetylcholine (ACh) and norepinephrine on insulin and glucagon secretion in response to changes in glucose concentration, using perfused pancreas preparations. Basal insulin secretion at a blood glucose level of 5.6 mmol/l was significantly higher and basal glucagon secretion significantly lower in streptozotocin-induced diabetic rats than in controls, and neither high (16.7 mmol/l) nor low (1.4 mmol/l) blood glucose concentrations influenced insulin or glucagon secretion. Addition of 10−6 mol/l ACh to the perfusate increased glucose-stimulated insulin secretion. Also, 10−6 mol/l ACh, 10−7 mol/l norepinephrine, as well as a combination of both, induced marked glucagon secretion, this was suppressed by high blood glucose level. Although simultaneous addition of 10−6 mol/l ACh and 10−7 mol/l norepinephrine induced only a slight increase in glucagon secretion in response to glucopenia, there was a significant increase in glucagon secretion in conjunction with an ambient decrease in insulin. Histopathological examination revealed a marked decline in acetylcholinesterase and monoamine-oxidase activities in the islets of streptozotocin-induced diabetic rats. We speculate that reduction of the potentiating effects of ACh and norepinephrine lessens glucose sensitivity of islet beta and alpha cells in this rat model of diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401759
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  • 7
    Electronic Resource
    Electronic Resource
    Fan-shaped hepatic parenchymal damage after ethanol injection therapy for hepatocellular carcinoma: MRI appearances (1999)
    Springer
    Abdominal imaging 24 (1999), S. 56-60 
    Details
    ISSN: 1432-0509
    Keywords: Key words: Magnetic resonance imaging (MRI)—Liver—Hepatocellular carcinoma—Percutaneous ethanol injection therapy—Parenchymal damage.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: T1- and T2-weighted magnetic resonance (MR) images frequently show fan-shaped areas of hypo- or hyperintensity in the hepatic parenchyma adjacent to a treated hepatocellular carcinoma after percutaneous ethanol injection (PEI) therapy. These areas correspond to abnormal contrast enhancement on serial dynamic MR images. The purpose of the present study was to describe the location, appearance, and frequency of these abnormalities because it is important to understand these entities for the correct assessment of therapeutic efficacy. Methods: MR imaging including a multisection dynamic study was performed in 20 consecutive patients with hepatocellular carcinoma treated with PEI therapy. We retrospectively evaluated the presence of fan-shaped hypointensities adjacent to treated tumors in the liver parenchyma on T1-weighted images and hyperintensities on T2-weighted images and corresponding fan-shaped contrast enhancement on both arterial-dominant and delayed-phase dynamic MR images. We review the location, appearance, and frequency of these findings, and we discuss the possible causes on the basis of pathologic examinations. Results: Seven (35%) of the 20 patients showed fan-shaped hyperintense areas adjacent to the treated tumors on T2-weighted images. These areas showed isointensity in five patients and hypointensity in two patients on T1-weighted images. Of these seven patients, one (14%) underwent the MR imaging within 1 month after the completion of PEI therapy, and six (86%) had it 2–9 months after the completion of PEI therapy (mean = 6 months). In all seven patients, fan-shaped hyperperfusion abnormalities corresponding to these areas of hyperintensity on T2-weighted images were seen on both arterial-dominant and delayed-phase dynamic MR images. Pathologically, the coagulative necrosis of the hepatocytes with sinusoidal dilatation and the restoration by the development of fibrous tissue were seen in these fan-shaped areas. Conclusion: The fan-shaped areas of abnormal intensity on T1- and T2-weighted images and contrast enhancement on dynamic MR images seem to be attributable to pathologic changes in the normal liver parenchyma induced by the toxic reaction of ethanol. Awareness of the occurrence of such abnormalities in the peripheral liver parenchyma adjacent to the treated tumor is important for the correct assessment of therapeutic efficacy. RID=""ID=""〈e5〉Correspondence to:〈/e5〉 T. Fujita
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900440
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  • 8
    Electronic Resource
    Electronic Resource
    Homogeneous enhancement of hepatic parenchyma: MR imaging during arterial portography versus CT during arterial portography (1998)
    Springer
    Abdominal imaging 23 (1998), S. 51-55 
    Details
    ISSN: 1432-0509
    Keywords: Key words: MR during arterial portography—CT during arterial portography—Liver—Gadolinium.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Background: The goal of this study was to investigate the frequency of inhomogeneous parenchymal enhancement of the liver in magnetic resonance imaging during arterial portography (MRAP) versus computed tomography during arterial portography (CTAP). Methods: CTAP and MRAP were performed in 29 and in 21 patients, respectively, who had suspected primary or secondary liver tumors on clinical or biological grounds. We evaluated the frequency of inhomogeneous hepatic parenchymal enhancement not related to a decrease of portal blood supply due to compression or obstruction by the tumor and physiologic variation in portal perfusion. Inhomogeneous parenchymal enhancement of the liver was classified as segmental or subsegmental and as nonsegmental. Results: Segmental or subsegmental inhomogeneous parenchymal enhancement was seen in six of 29 patients (20.1%) on CTAP and in one of 21 patients (4.8%) on MRAP. Nonsegmental inhomogeneous parenchymal enhancement was seen in five of 29 patients (17.2%) on CTAP images and in none of the patients (0%) on MRAP images. The incidence of nonsegmental inhomogeneous parenchymal enhancement was significantly lower on MRAP than on CTAP. Conclusion: MRAP was superior to CTAP in achieving homogeneous parenchymal enhancement of the liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002619900284
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  • 9
    Electronic Resource
    Electronic Resource
    Free MRA of the abdomen: postprocessing dynamic gadolinium-enhanced 3D axial MR images (2000)
    Springer
    Abdominal imaging 25 (2000), S. 62-66 
    Details
    ISSN: 1432-0509
    Keywords: Key words: MRI—Technique—MR angiography—Abdomen—Contrast agents.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dynamic contrast-enhanced whole-abdomen axial images were obtained by using a fat-suppressed, three-dimensional, breath-hold enhanced fast spoiled gradient-echo technique, configured for optimal evaluation for detection and characterization of liver lesions. We then evaluated the feasibility of using these images to reconstruct “free” abdominal magnetic resonance angiography, without additional cost or acquisition time, in 32 randomly chosen patients. The aorta, celiac trunk, superior mesenteric, hepatic, splenic, and renal arteries were clearly depicted.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/s002619910013
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  • 10
    Electronic Resource
    Electronic Resource
    Hepatic morphologic changes in cirrhosis: MR imaging findings (2000)
    Springer
    Abdominal imaging 25 (2000), S. 456-461 
    Details
    ISSN: 1432-0509
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1107/s002610000013
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