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  • 1
    ISSN: 1432-2161
    Keywords: Bone mineral density ; Quantitative computed tomography ; Magnetic resonance ; Marrow fat ; Collagen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the usefulness of assessing bone components using magnetic resonance imaging (MRI), the contributions of bone components, including mineral, fat and collagen, to bone mineral density (BMD) and T1 relaxation time (T1) were studied using phantoms. Excised human vertebrae were also evaluated by quantitative computed tomography (QCT) and MRI. T1 was shortened with increasing quantities of fat and collagen. In water, T1 was significantly affected by bone density, while in oil, T1 became slightly longer as bone density increased. The presence of fat and collagen caused under- and overestimations of BMD, respectively. There was good correlation between T1 and BMD in osteoporotic vertebrae and the vertebrae with long T1 showed an increased content of hematopoietic marrow and/or abnormally increased bone mineral. It was concluded that the experimental data showed that MRI can contribute to the assessment of bone quality.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-5604
    Keywords: hypoparathyroidism ; bone mineral density ; age-related bone loss
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Parathyroid hormone (PTH) is a key factor involved in the systemic regulation of bone resorption. It is well known that a high turnover of bone occurred together with the reduced bone mass in patients with hyperparathyroidism. However, the effect of subnormal secretion of PTH on age-related bone loss has not been extensively investigated. Recently, some investigators and us have focused on the effect of suppressed PTH secretion and have demonstrated that patients with subnormal secretion of PTH preserved a relatively higher bone mineral densities than age- and sex-matched controls. We believe that these results will give a new insight into the mechanism of age-related bone loss or osteoporosis. Further studies are needed to evaluate the mechanisms of this protective effect of suppressed PTH secretion on bone mass.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1435-5604
    Keywords: Key words: disuse osteoporosis ; nonweightbearing ; peripheral quantitative computed tomography (pQCT) ; bone mineral density (BMD)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: Tibial bone mineral density (BMD) was measured in 11 patients who had undergone hip joint surgery, including 10 women (22–61 years old; mean ± SD = 42.6 ± 10.3) and 1 man (61 years old). Four patients received total hip replacement (THR), while the others underwent rotational acetabular osteotomy (RAO). In one case, the start of rehabilitation was delayed until 4 months after the surgery because of infection at the surgical site. Nine patients underwent hip surgery for osteoarthritis and 2 patients for avascular necrosis. These 2 patients had a history of medication with corticosteroid. BMD of the tibia on the surgically treated side was measured by a peripheral quantitative CT (pQCT) system, which provided three different BMD values of trabecular BMD in the distal portion, total BMD in the distal portion, and total BMD in the diaphysis. The measurements were obtained preoperatively, and at several time points postoperatively, at 2, 4, 6, and 8 weeks and 3, 4, 5, 8, 12, 18, and 24 months after surgery. Brief periods of nonweightbearing lead to significant bone loss, and 1–1.5 years was required to recover to the baseline BMD. Accelerated bone loss was seen in patients in the perimenopausal state, with prolonged bed rest, and in patients receiving corticosteroid. Both trabecular and cortical components were influenced by nonweightbearing and restoration of weightbearing. The decrease in the cortical region occurs after the decrease in the trabecular and endosteal regions.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-0743
    Keywords: coronary artery-cardiac chamber shunt (CA-CC shunt) ; coronary angiography ; coronary arteries ; hypertrophic cardiomyopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Coronary artery-cardiac chamber shunts (CA-CC shunts) were observed in 101 out of 2267 consecutive patients (4.5%) receiving selective coronary angiography. In these patients, contrast medium injected into the coronary artery escaped directly into the cardiac chamber. CA-CC shunts were angiographically classified into the following two types. Type I: The endocardial layer was diffusely opacified, and contrast medium escaped into the cardiac chamber on systole (n=83). Type II: Contrast medium escaped directly into the cardiac chamber via an undilated branch (n=11). Type I and type II shunts were observed simultaneously in 7 patients. It is speculated that type I is a shunt via a persistent arterio-sinusoidal vessel, while type II is a shunt via a persistent arterio-luminal vessel. Both types were observed frequently (24.9%) in hypertrophic cardiomyopathy. The degree of CA-CC shunts in hypertrophic cardiomyopathy was not influenced by the presence or absence of myocardial squeezing. CA-CC shunts are considered to be due to an abnormality in the coronary microcirculation of the myocardium. We describe the angiographic features of the two types of CA-CC shunt and discuss their pathophysiological significance.
    Type of Medium: Electronic Resource
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