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  • 1
    ISSN: 1432-1440
    Keywords: Bromocriptin ; Prostatakarzinom ; Prolaktin ; Androgene ; Testosteron ; Bromocriptine ; Prostatic Carcinoma ; Prolactin ; Androgens ; Testosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In 12 patients with advanced prostatic carcinoma the effect of bromocriptine-induced hypoprolactinemia on the peripheral androgen metabolism was investigated after3H-testosterone injection under conditions that each individual served as his own control. After a 5-day significant prolactin suppression, the elimination of3H-label 1 h after testosterone injection was about 45% and equal to pre-bromocriptine values. The recovery of dihydrotestosterone separated by silica gel T.L.C., however, was significantly augmented, resulting in a marked decrease of the testosterone/dihydrotestosterone ratio from 12.2 to 6.3. This induced 5α-reductase activity after prolactin suppression is in accordance with our earlier findings on prostatic carcinoma tissue, matches well with observations of Magrini et al. on induced hyperprolactinemia and may be a new approach to the understanding of androgen dependent disorders.
    Notes: Zusammenfassung Beeinflussung des peripheren Testosteronstoffwechsels durch induzierte Hypoprolaktinämie bei Patienten mit Prostatakarzinom. Der Effekt einer Bromocriptin-induzierten Hypoprolaktinämie auf den peripheren Androgenstoffwechsel wurde bei 12 Patienten mit fortgeschrittenem Prostatakarzinom nach Injektion von3H-Testosteron in der Weise untersucht, daß jeder Patient als seine eigene Kontrolle galt. Nach einer fünftägigen Hypoprolaktinämie betrug die Elimination androgengebundener Radioaktivität 1 Stunde nach Testosteroninjektion 45% und entsprach dem Wert vor Bromocriptinbehandlung. Die durch Silica Gel-Dünnschichtchromatographie analysierte Recovery von Dihydrotestosteron war allerdings signifikant erhöht. Daraus ergab sich eine deutliche Verminderung des Verhältnisses Testosteron/Dihydrotestosteron von 12.2 auf 6.3. Diese induzierte Kapazität der 5α-Reduktase nach peripherer Prolaktin-Suppression steht in Übereinstimmung mit unseren früheren Ergebnissen an Prostatakarzinomgewebe, wird unterstützt durch Beobachtungen von Magrini et al. bei induzierter Hyperprolaktinämie und könnte wichtige Rückschlüsse für das Verständnis androgenabhängiger Krankheitsbilder liefern.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 103 (1968), S. 277-284 
    ISSN: 1432-1076
    Keywords: Meningokokkenmeningitis ; Meningokokkensepsis ; Defektzustände
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurden 200 Kinder im Alter von 2–171/2 Jahren nach einer in den Jahren 1955–1966 abgelaufenen Meningokokkenmeningitis und-sepsis eingehend nachuntersucht. Die Probanden wurden einer ausführlichen klinisch-neurologischen Untersuchung, einer Elektrencephalographie, Echoencephalographie und einem Kramer-Intelligenztest unterzogen. Dabei fanden sich bei 39,5% restlose Heilungen, bei 35% leichte und bei 19,5% schwerere Restschäden. Mit zunehmendem Alter der Kinder verringerten sich die schweren Spätschäden. Die restlichen 6% ließen nicht ausschließen, daß der zentral-nervöse Schaden nicht schon vor der Meningitis bestand bzw. nur eine Verschlimmerung durch die Erkrankung erfuhr. Da es sich um Nachuntersuchungen bei Überlebenden aus zum Teil entfernten Gegenden handelt, liegen keine Zahlen über die Letalität in dieser Zeit vor.
    Notes: Summary 200 children of 2 to 171/2 years of age who have had a meningococcal meningitis or -sepsis in 1955–1966 have been reexamined. The patients were submitted to an extensive neurological examination with electroencephalography and echoencephalography and a Kramer-intelligencetest. 39,5% of the patients were found to be completely cured, 35% had mild, 19,5% had severe residual damage. With increasing age of the children the severe damage lessened. In 6% of the patients a preexistent cerebral damage which was aggravated by the meningitis could not be ruled out. Letality numbers during this time could not be established as the surviving patients came out of distant areas.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1076
    Keywords: Key words Coagulation ; Fibrinolysis ; Head injury ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study was designed to evaluate the post-trauma haemostatic changes in 27 children with severe cranio-cerebral trauma defined by a modified Glasgow Coma Score (GCS) 〈10. Blood samples for coagulation studies (fibrinogen, von Willebrand factor (vWf), factor VIII:C, antithrombin, protein C, plasminogen, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI), D-dimer) were obtained within two hours of admission, 24 h later, and on days 3–5, 7–9, 21 and 35. Data of this study indicate that alterations of coagulation in paediatric patients are similar to those in adults: On hospitalisation, activated haemostasis was found with decreased fibrinogen, antithrombin and protein C along with enhanced t-PA and PAI. Twenty-four hours later, hypercoagulability with significantly increased vWF and fibrinogen started, with a peak level within the second week. Within 24 h of admission, 17 children developed disseminated intravascular coagulation (DIC) with a clear-cut decrease of antithrombin and fibrinogen together with platelet consumption and enhanced D-dimer. The outcome of children with DIC was significantly poorer than in those without DIC. Complete recovery was seen in five patients; sequelae no handicap and moderate disability were each found in six patients. Severe disability was diagnosed in two children, and fulminant DIC with lethal outcome occurred in eight patients. The GCS (P 〈 0.01) and the occurrence of DIC (P 〈 0.005) showed the strongest association with the patients' clinical outcome. Conclusion Our data underline the significance of post-trauma disturbances of the haemostatic system for the clinical course and outcome in children with severe cranio-cerebral injuries.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    BBA Section Nucleic Acids And Protein Synthesis 145 (1967), S. 470-484 
    ISSN: 0005-2787
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    BBA - Biochimica et Biophysica Acta 58 (1962), S. 155-170 
    ISSN: 0006-3002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Freshwater biology 8 (1978), S. 0 
    ISSN: 1365-2427
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SUMMARY. Benthic macroinvertebrate distribution, abundance, and composition were observed in a fluctuating (7.7 m) central Wisconsin, U.S.A., reservoir during 1973–74. Chironomidae and Oligochaeta represented 98% of the total fauna by number. The chironomid, Chironomus plumosus, and an oligochaete, Limnodrilus, each averaged 36% of the total benthic biomass. Annual mean numbers and biomass in areas exposed to air, exposed to ice cover, or remaining inundated were 3025/m2 (1.8g/m2), 4311/m2 (4.5g/m2), and 8558/m2 (16.0 g/m2), respectively. A substantial portion of the benthic fauna was stranded and subsequently decreased rapidly in drying and frozen substrates exposed to air. Total benthic numbers and biomass were greatest immediately below the drawdown limit.Recolonization required 3 months (mid-March to mid-June, 1974) to attain pre-drawdown values for numbers and biomass, and subsequently both were greater after reinundation than before the substrate was exposed. Recolonization of areas exposed to the air was greater in substrates containing large amounts of organic matter than in sandy areas containing little organic matter. Sorting and transportation of sediments redistributed organic materials from the regulated zone to below the drawdown limit, and macrophytes were eliminated from the regulated zone. When compared to other reservoirs and lakes, the density of benthos in the Big Eau Pleine Reservoir is neither high nor low. However, when compared with non-fluctuating reservoirs the number of Ephemeroptera, Plecoptera, Trichoptera, Amphipoda, and Gastropoda was low.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 21 (1992), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The clinicopathological features of two infants with desmoplastic supratentorial neuroepithelial tumours are described. The cases were similar to the 26 cases reported previously as desmoplastic infantile ganglioglioma and superficial cerebral astrocytoma attached to dura. Neuronal differentiation was absent on routine stains, but was immunohistochemically established. We review the literature and suggest classifying this clinicopathological entity by using a general designation such as desmoplastic supratentorial neuroepithelial tumours of infancy, a term which indicates the variability in the amount and lines of differentiation.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Plant Science Letters 5 (1975), S. 67-71 
    ISSN: 0304-4211
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 28 (1987), S. 197 
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1573-7276
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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