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  • 1
    Electronic Resource
    Electronic Resource
    Der Einfluss des Arginins, der Leber- und Magenextrakte auf die B-Avitaminose bei Tauben (1935)
    Springer
    Journal of molecular medicine 14 (1935), S. 379-380 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Tauben erhielten als Nahrung geschälten und 5 Stunden lang in fließendem Wasser gewaschenen Reis, dazu 2 proz. Salzmischung (Nr. 185) nachMcCollum und 1/4% Lebertran. 1. Die Kontrolltiere verendeten in 13 bis 24 Tagen. 2. Bei der Verabreichung eines Vitamin B-Präparates, welches aus Bäckerhefe mit saurem verdünntem Alkohol (pH ungefähr 4,5) zubereitet worden war, blieben die Tiere 22–36 Tage am Leben. 3. Verwendung eines Schweineleberextraktes bereitet mit demselben verdünnten sauren Alkohol: die Tiere lebten 10–39 Tage. 4. Extrakt aus dem Schweinemagen auf ähnliche Weise zubereitet: die Tiere blieben 22–36 Tage lang am Leben. 5. Nach der Verabreictung von Arginin blieben die Tiere 22–36 Tage am Leben. (Im Durchschnitt lebten diese am längsten.) 6. Auch die aus Kulturen von B. mesentericus, subtilis oder pyocyaneus mit saurem Alkohol hergestellten Extrakte konnten das Leben der Tiere bis zu 27–29 Tage verlängern. 7. Der Vitamin B-Komplex enthält einen Faktor, dessen Mangel auch Anämie verursacht. Dieser Faktor kann vielleicht teilweise mit dem Arginingehalt des Vitamin B zusammenhängen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01780440
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  • 2
    Electronic Resource
    Electronic Resource
    Eine Abstammungslehre der Lymphocyten, als Grundlage für Analysierung der Blutveränderungen und Bluterkrankungen (1936)
    Springer
    Journal of molecular medicine 15 (1936), S. 718-723 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01779457
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  • 3
    Electronic Resource
    Electronic Resource
    The effect on escherichia coli B of “radioprotectors” produced by fermentation (1962)
    Springer
    Archives of microbiology 44 (1962), S. 228-232 
    Details
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. The radioprotective activity of several hundreds of fermentation liquids have been examined by methods described in our previous reports. 2. Out of the tested fermentation liquids, good protective ability was rendered—mainly after acid hydrolysis—by the fermentation liquid of Penicillium notatum strain which is applied also in industry. 3. The agent, when it was produced, proved to be d-Penicillamine. 4. The radioprotective activity of d-Penicillamine as well as its ability to reduce the toxicity of nitrogen mustard have been compared with the effect of other wellknown radioprotectors, on an equimolar basis. 5. It was found that its protective ability for E. coli B against both X-ray and nitrogen mustard is about the same degree as that of cysteine. 6. From the results, theoretical and practical conclusions have been drawn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510942
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  • 4
    Electronic Resource
    Electronic Resource
    Screening-Methode zum Nachweis der Strahlenschutzwirkung von Streptomyces-Fermentsäften (1961)
    Springer
    Archives of microbiology 40 (1961), S. 119-125 
    Details
    ISSN: 1432-072X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Zusammenfassung 1. Zum Nachweis von biologischen radioprotektiven Substanzen wurde eine mikrobiologische Screening-Methode ausgearbeitet. 2. Bei diesen Untersuchungen wurden Escherichia coli 0 111 und Streptomyces bikiniensis als Testorganismen verwendet. 3. Die Empfindlichkeit des Tests wurde mit Dosen von 1, 10, 100 μg der bekannten Radioprotektoren kontrolliert. 4. Unter den in äquimolaren Dosen verglichenen Protektoren erwiesen sich die SH-Stoffe an beiden Mikroorganismen am wirksamsten. 5. Unter 40 unbekannten Streptomyces-Fermentsäften fanden wir zwei wirksame.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410002
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  • 5
    Electronic Resource
    Electronic Resource
    Altered glycosaminoglycan composition in reactive and neoplastic human liver
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 167 (1990), S. 883-890 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(90)90606-N
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  • 6
    Electronic Resource
    Electronic Resource
    The antiproliferative action of a melphalan hexapeptide with collagenase-cleavable site (1998)
    Springer
    Cancer chemotherapy and pharmacology 41 (1998), S. 292-298 
    Details
    ISSN: 1432-0843
    Keywords: Key words Prodrugs ; Collagenase ; Melphalan ; HT-1080
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: The objective of the present study was to examine the relevance of collagenase in the antitumor action of a melphalan peptide (MHP) with a collagenase-cleavable sequence. The question was addressed as to whether collagenase may act as an activator or a target in the antiproliferative mechanism of MHP. Methods: Melphalan was inserted into peptides representing the sequence Pro-Gln-Gly-Ile-Ala.Gly of the collagenase-cleavable site in collagens. Changes in growth and collagenase IV activities of HT-1080, HT-29, HT-168, and MCF-7 cell cultures were investigated. Results: The present investigations provide data indicating that Pro-Gln-Gly-Ile-Mel-Gly (melphalan hexapeptide, MHP) is a substrate for both bacterial and 72-kDa type IV collagenases and that in this way it can generate Ile-Mel-Gly (melphalan tripeptide, MTP) of higher cytotoxic potency. Indeed, the formation of MTP was detected in the conditioned medium of HT-1080, a collagenase IV-producing human fibrosarcoma. In a comparison of equimolar concentrations of melphalan and its two peptide derivatives (MHP and MTP), superior antiproliferative action of MTP was seen in HT-29, HT-1080, and HT-168 tumor cell cultures. However, the relatively modest cytostatic actions of MHP were increased when bacterial collagenase was added to the cell cultures. After melphalan treatment, reduced levels of both 92 and 72-kDa type IV collagenases were seen in the HT-1080 cell cultures. However, the reduction of collagenase activity and the cell counts did not run parallel in the MTP- or MHP-treated cultures; indeed, collagenase activity related to cell numbers showed an elevated level. Conclusions: As the conversion of MHP to the more toxic MTP was detected in the presence of collagenases, it is possible that collagenase-directed activation of prodrugs may be a promising approach for the development of more selective cytostatic drugs against malignant tumors with high collagenase activities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002800050742
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  • 7
    Electronic Resource
    Electronic Resource
    Antitumor action of N-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of biologically active polypeptide hormone fragments (1986)
    Springer
    Cancer chemotherapy and pharmacology 16 (1986), S. 129-132 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The antitumor action of the 2-chloroethylnitrosocarbamoyl derivatives of peptides related to the 9–13 amino acid residues of α-MSH/ACTH and of the C-terminal tetrapeptide analogue of gastrin have been investigated. Series of 2-chloroethylnitrosoureas attached to amino acids, di-, tri-, tetra-, or pentapeptides were examined in a primary screening system. Among these compounds the Pro-Val-, Lys-Pro-Val-, and Trp-Gly-Lys-Pro-Val-containing 2-chloroethylnitrosocarbamoyl groups were the most effective in the L1210 system. The human melanoma xenograft line was also affected by these agents, while colorectal xenografts were insensitive. A combination of tripeptide-2-chloroethyl-nitrosourea with BCNU induced more than additive growth inhibition of L1210 leukemia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00256162
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  • 8
    Electronic Resource
    Electronic Resource
    Studies on in vitro carcinogenesis (1976)
    Springer
    Journal of cancer research and clinical oncology 85 (1976), S. 117-124 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Einbau von radioaktiv markiertem Methylcholanthren wurde autoradiographisch (Licht-und Elektronenmikroskopie) und mit der Liquid-Szintillationsmethode untersucht. Nach 24 stündiger Behandlung mit einer Methylcholanthren-Konzentration von 0,01–2,5 μg/ml stehen die Zahlen der markierten Zellen und auch die Silberkornzellen in Korrelation mit der Behandlungszeit und mit den angewandten Dosen. Nach Behandlung mit 2,5 μg/ml Methylcholanthren sind alle Zellen markiert, bei 0,01 und 0,1 μg/ml nur 2 bzw. 10% der Zellpopulation. Diese Ergebnisse weisen darauf hin, daß der Markierungsindex früher 100% erreicht als das bei der Durchschnittszahl der Silberkörner zu erwarten ist. Die elektronenmikroskopische Autoradiographie zeigt eine ziemlich gleichmäßige Verteilung der Silberkörner und keine bevorzugte Bindungsstelle des Methylcholanthrens. Durch biochemische Analysen wird gezeigt, daß 1 Std und 24 Std nach Beginn der Behandlung 59 bzw. 44% der Radioaktivität an die Makromoleküle gebunden ist.
    Notes: Summary The incorporation of radioactive labelled Methylcholanthrene into CBA/T6T6 mouse embryonic fibroblast cultures was studied by using light and electronmicroscopic autoradiographic and also liquid scintillation counting techniques. During 24 hrs treatment time at the applied Methylcholanthrene concentrations (0.01–2.5 μg/ml) the proportion of cells labelled with 3H-Methylcholanthrene and the number of grains above the cells showed a relationship with the duration of treatment and also with the doses. Up to 24 hrs all cells were labelled after treatment with 2.5 μg/ml whereas at 0.01 and at 0.1 μg/ml concentrations Methylcholanthrene could have been detected only 2 and 10% of the cell population resp. The presented results suggested that labelling index reached saturation level earlier than the average number of grains. Electronmicroscopic autoradiography revealed a rather even distribution of grains and there were no signs for preferential binding site of Methylcholanthrene. Biochemical separation showed that 59 and 44% of the radioactivity was bound to macromolecules at 1 and 24 hrs after commencing treatment resp.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00304944
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  • 9
    Electronic Resource
    Electronic Resource
    Untersuchungen über den Zusammenhang von biologischen Wirkungsunterschieden und Verteilungsparametern bei 1,6-Dibromhexiten (1971)
    Springer
    Journal of cancer research and clinical oncology 75 (1971), S. 133-145 
    Details
    ISSN: 1432-1335
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wurde die Gewebeverteilung von C14-markiertem 1,6-Dibrommannit (DBM) und 1,6-Dibromdulcit (DBD) in vivo an Mäusen untersucht. Die in vivo-Gewebekumulation des über eine stärkere cytostatische Wirkung und ein breiteres tumorhemmendes Spektrum verfügenden Dibromdulcit war von größerem Ausmaß als die des Dibrommannit. Der in der intracellulären Kumulationsfähigkeit beider 1,6-Dibromhexite gefundene Unterschied zeigte auch quantitativ gute Übereinstimmung mit den zur Auslösung gleicher biologischer Wirkung benötigten Dosisunterschieden, bzw. gab Aufklärung über die Vertiefung und Spezialisierung der biologischen Wirkungen. In der in vitro-Zellpenetrationsuntersuchung bei den gegenüber Dibromhexiten sensitiven Yoshida, bzw. refraktären S-180-Ascitestumorzellen wurde die Aufnahme des 1-C14- und 1,6-di-Br82-markierten 1,6-Dibrommannit bzw. 1,6-Dibromdulcit untersucht. Von den in der Dibromhexitempfindlichkeit verschiedenen Tumorzellen wurden aus den C14- und Br82-markierten Verbindungen Radiobrom und Radiocarbon in verschiedenem Verhältnis aufgenommen bzw. beständig angebunden. Deshalb ist anzunehmen, daß sich die Biotransformationen beider Dibromhexite im Aufnahmevorgang hauptsächlich hinsichtlich des Spaltungsorts und der Spaltungsgeschwindigkeit ihrer C-Br-Bindungen voneinander unterscheiden.
    Notes: Summary Tissue distribution of C14-labelled 1,6-dibromomannitol (DBM) and 1,6-dibromodulcitol (DBD) was investigated in vivo in mice. The in vivo tissue accumulation of dibromodulcitol possessing a stronger cytostatic effect and broader antitumour spectrum was greater than that of dibromomannitol. The difference between the intracellular accumulation abilities of both 1,6-dibromohexitols showed a good quantitative agreement with the differences of doses required for producing identical biologic actions; thereby intensification and specialisation of the biological effects could be interpreted. The in vitro cell studies of the uptake of 1-C14 and 1,6-di-Br82 labelled 1,6-dibromo-D-mannitol and of 1,6-dibromodulcitol, respectively were mode in Yoshida tumour cells sensitive to dibromohexitols and in S-180 ascites cells resistant to the same drugs. Tumour cells, which were different in their dibromohexitol sensitivities, took up or bound steadily radiocarbon and radiobromine from Br82 and C14-labelled compounds in a different ratio. It was presumable that biotransformations of both dibromohexitols differed in the course of the uptake process, mainly in respect to place and velocity of the decomposition of their C-Br bonds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00525934
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  • 10
    Electronic Resource
    Electronic Resource
    Comparative study on Lewis lung tumor lines with ‘low’ and ‘high’ metastatic capacity. II. Cytochemical and biochemical evidence for differences in glycosaminoglycans (1987)
    Springer
    Clinical & experimental metastasis 5 (1987), S. 79-87 
    Details
    ISSN: 1573-7276
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The enhanced metastatic capacity of an in vivo selected Lewis lung tumor line (LLT-HH) was correlated with changes in cell-associated glycosaminoglycans (GAG) using ultrastructural cytochemistry, flow cytometry and biochemistry. The increase in highly sulphated GAG content on the cell membrane of LLT-HH cells compared to the parent LLT cells was demonstrated cytochemically. Using in vitro [3H]glucosamine labelling of GAG components it was shown that the LLT-HH cells were characterized by a high production of heparan sulphate while the parent LLT line had a high hyaluronic acid-chondroitin sulphate production. The high metastatic phenotype is accompanied by an altered production of cell-associated GAGs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00116628
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