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  • 1
    Electronic Resource
    Electronic Resource
    Erosion of Surfaces by Liquid Drops (1955)
    [s.l.] : Nature Publishing Group
    Nature 176 (1955), S. 303-304 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To study the fundamental mechanics of the erosion process an apparatus is required which will reproduce the high-speed impact between a single drop and a surface. Due to the low relative speeds at which water drops shatter1, difficulty is experienced in accelerating a water drop of the size ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/176303a0
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  • 2
    Electronic Resource
    Electronic Resource
    Therapeutic potentiation of the immune system by costimulatory Schiff-base-forming drugs (1995)
    [s.l.] : Nature Publishing Group
    Nature 377 (1995), S. 71-75 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We first studied the potent immunopotentiatory properties of small Schiff base-forming molecules as a class in human CD4 T cells responding to antigen in vitro (Fig. la). Specific murine Th-cell priming in vivo is also substantially enhanced after local administration of this class of drug (Fig. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/377071a0
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  • 3
    Electronic Resource
    Electronic Resource
    An experimental method for studying the high speed impact of a liquid drop on a liquid surface (1967)
    Springer
    Archive of applied mechanics 36 (1967), S. 280-284 
    Details
    ISSN: 1432-0681
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Übersicht Es wird eine experimentelle Methode zur Untersuchung des Aufprallens von Flüssigkeitstropfen auf eine Flüssigkeitsoberfläche beschrieben, bei der die flüssige Fläche mit hoher Geschwindigkeit gegen einen stationären Tropfen bewegt wird. Fotos des Aufprallvorgangs bei Geschwindigkeiten von 47,7 m/s mit Tropfen von 0,175 cm Durchmesser werden gezeigt. Weiterhin werden Vorschläge gemacht, wie bei künftigen Untersuchungen ] gewisse Unterschiede in den Ergebnissen nach der hier beschriebenen Methode und bei frei fallenden Tropfen aufgeklärt werden könnten.
    Notes: Summary An experimental method for studying the high speed impact of a liquid drop on a liquid surface is described in which the liquid surface is moved against the stationary drop. Photographs are presented of the impact of a water surface at 47,7 m/sec on a stationary water drop 0,175 cm diameter. Proposals are made for further work to resolve certain discrepancies between results obtained using this method and those derived from earlier work in which drops fall freely onto a standing surface.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634564
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Percentage development of a second infection of Nippostrongylus brasiliensis in rats (1970)
    Springer
    Parasitology research 33 (1970), S. 355-357 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00331471
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  • 5
    Electronic Resource
    Electronic Resource
    An in vitro screen for new fasciolicidal agents (1984)
    Springer
    Parasitology research 70 (1984), S. 655-661 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In vitro screens employing newly excysted, 6- and 12-week-old flukes, in a medium permitting the linear growth of the parasites, were assessed. When exposed to certain known fasciolicides, newly excysted flukes were susceptible only to diamphenethide, the free amine of diamphenethide, emetine hydrochloride and albendazole. Older flukes were affected by a much wider range of compounds including the chlorinated hydrocarbons, the substituted phenols and the salicylanilides. However their susceptibility to diamphenethide and its active metabolite was decreased significantly. The activity of fasciolicides in these in vitro assays therefore closely parallels their activity in vivo. When several broad spectrum anti-nematode agents were evaluated against newly excysted flukes in these screens the benzimidazole, isothiocyanate, pyrimidine and imidazothiazole anthelmintics showed activity but 12 potent antiprotozoal agents were all inactive. It is concluded that these in vitro assays were useful for detecting any intrinsic activity that a compound might possess against flukes. Such activity could often be missed in conventional in vivo screens because of problems associated with host pharmacokinetics. Negative results from such in vivo screens could preclude the development of more bioavailable derivatives or pro-drugs as novel and useful fasciolicidal agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00926594
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  • 6
    Electronic Resource
    Electronic Resource
    Improved detection of anthelmintic activity in an in vitro screen utilizing adult Nippostrongylus brasiliensis (1987)
    Springer
    Parasitology research 73 (1987), S. 190-191 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00536481
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  • 7
    Electronic Resource
    Electronic Resource
    A new primary screening test for anthelmintics utilizing the parasitic stages ofNippostrongylus brasiliensis, in vitro (1980)
    Springer
    Parasitology research 63 (1980), S. 261-269 
    Details
    ISSN: 1432-1955
    Keywords: In vitro culture ; Anthelmintics ; Primary screening test ; Nippostrongylus brasiliensis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A new in vitro test suitable for the large scale screening of chemical compounds for anthelmintic activity is described. The test which utilizes the fourth larval and adult stages ofNippostrongylus brasiliensis in a medium capable of supporting the growth and development of the parasite, detects selectively those compounds which possess either broad spectrum anthelmintic or specific anti-trichostrongyle activity. The screen is easy to operate requiring only minute quantities of experimental compound. It renders fully reproducible results which furthermore can be interpreted objectively. This is the first reported in vitro test directed against the parasitic stages of a nematode that is capable of detecting reliably the activity of a wide range of anthelmintics including thiophanate and all the benzimidazoles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00931988
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  • 8
    Electronic Resource
    Electronic Resource
    Nematospiroides dubius: response of the late fourth-stage larva to anthelmintics in vitro (1984)
    Springer
    Parasitology research 70 (1984), S. 395-402 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Approximately 60% of fourth-stage larvae ofNematospiroides dubius recovered from mice 6 days after infection, developed to the young adult stage when cultured over a 7-day period in a complex medium in vitro. Larvae at the late fourth stage of development were found to be highly susceptible to most broad spectrum anthelmintics under in vitro conditions, the benzimidazole, imidazothiazole, pyrimidine, isothiocyanate and macrocyclic lactone compounds all being active at very low concentrations. Narrow spectrum anthelmintics active only against ascarids, pinworms, filariae, cestodes or trematodes had little or no effect on these larvae. Ineffective also were those chlorinated hydrocarbon, substituted phenol and salicylanilide compounds known to affectHaemonchus but not trichostrongylid worms in general. It is concluded that in vitro assays employing larvae ofN. dubius are useful for the stringent screening of compounds for broad spectrum antitrichostrongyle activity. Used in conjunction with in vivo screens employingN. dubius in mice, they also afford means for detecting intrinsic activity against the parasite in a system free from any complicating host pharmacokinetics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00927827
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  • 9
    Electronic Resource
    Electronic Resource
    Wasseruntersuchung (1943)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 126 (1943), S. 354-359 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01461128
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