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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Cytopathology 10 (1999), S. 0 
    ISSN: 1365-2303
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In cervical smears from post-menopausal women with mucosal atrophy it can be difficult to distinguish atrophic epithelial cell groups from neoplastic cell groups on cytomorphological criteria only. The consequence of post-menopausal atypia is that the woman is referred for a repeat smear after local oestrogen treatment or for colposcopy. We investigated whether immunocytochemical expression of Ki-67 (MIB-1) on the primary Papanicolaou-stained smear could be of any diagnostic help. Our data showed that negative Ki-67 expression is a very reliable indicator of a normal atrophic cell pattern, and by using this method on the original smear we were able to reduce the false-positive cytologic diagnoses by 86%.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Structural and multidisciplinary optimization 16 (1998), S. 246-257 
    ISSN: 1615-1488
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract In this paper, preference aggregation rules are used to define overall design evaluation measures in optimal design problems. A methodology for the efficient solution of the corresponding design optimization problems is presented. Each design criterion as well as the constraints imposed on the design variables and problem parameters are characterized by preference functions. The nondifferentiable nature of the optimization problems which arise in this formulation is coped with using a first-order algorithm combined with approximation concepts. High-quality approximations for the system response functions are constructed using the concepts of intermediate response quantities and intermediate variables. These approximations are used to replace the original problem by a sequence of approximate problems. Example problems are presented to study the performance of the proposed optimization technique as well as the methodology based on approximation concepts.
    Type of Medium: Electronic Resource
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