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  • 1
    Unknown
    Lexington, Ky : University Press of Kentucky
    Religion in the South  
    Keywords: Southern States, Church history. ; Revivals, Southern States.
    Pages: xvii, 236 p., [4] p. of plates
    ISBN: 0-8131-7065-6
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  • 2
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report is concerned with control of cell shaping, positioning, and cytoskeletal integration in a highly ordered cochlear neuroepithelium. It is largely based on investigations of events that occur during abnormal morphogenesis of the organ of Corti in the Bronx waltzer (bv/bv) mutant mouse. The organ's sensory hair cells and adjacent supporting cells ordinarily construct a spatially elaborate and supracellularly integrated cytoskeletal framework. Large microtubule bundles are connected to cytoskeletal components in neighbouring cells by actin-containing meshworks that link them to substantial arrays of adherens junctions. In bv/bv mice, degeneration and loss of most inner hair cells and outer pillar cells occurs during organ development. These cells flank each side of a row of inner pillar cells that respond by upregulating assembly of their actin-containing meshworks. This only occurs in surface regions where they no longer contact cell types involved in construction of the cytoskeletal framework. The meshworks are larger and exhibit a more extensive sub-surface deployment than is normally the case. Hence, assembly of intercellular cytoskeletal connecting components can proceed without contact with appropriate cell neighbours but termination of assembly is apparently subject to a negative feedback control triggered by successful completion of intercellular connection with the correct cell neighbours. In addition, inner pillar cells compensate for loss of cell neighbours by interdigitating and overlapping each other more extensively than is usually the case to increase opportunities for generating adherens junctions. Certain adherens junctions in the organs of +/+ and bv/bv mice exhibit features that distinguish them from all previously described cell junctions. The dense plaques on their cytoplasmic faces are composed of aligned ridges. We suggest that they are called ribbed adherens junctions. Perturbations of cell shaping and positioning indicate that loss of inner hair cells is the primary consequence of the bv mutation. Most of the other abnormalities can be understood in terms of a secondary sequence of morphogenetic aberrations (precipitated by loss of inner hair cells). These aberrations provide new information about the ways in which supporting cells help to control hair cell positioning.
    Type of Medium: Electronic Resource
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  • 3
    Book
    Book
    Providence, RI :American Math. Soc.,
    Title: Toric varieties /; 124
    Author: Cox, David A.
    Contributer: Little, John B. , Schenck, Henry K.
    Publisher: Providence, RI :American Math. Soc.,
    Year of publication: 2011
    Pages: XXIV, 841 S. : , graph. Darst.
    Series Statement: Graduate studies in mathematics 124
    ISBN: 978-0-8218-4819-7
    Type of Medium: Book
    Language: English
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  • 4
    Book
    Book
    Berlin u.a. :Springer,
    Title: ¬A¬ Course in Functional Analysis
    Author: Conway, John B.
    Publisher: Berlin u.a. :Springer,
    Year of publication: 1985
    Pages: 404 S.
    Type of Medium: Book
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  • 5
    Title: Ideals, varieties, and algorithms : an introduction to computational algebraic geometry and commutative algebra
    Author: Cox, David A.
    Contributer: Little, John B. , O'Shea, Donal
    Edition: 4. ed.
    Publisher: Cham [u.a.] :Springer,
    Year of publication: 2015
    Pages: XVI, 646 S. : , Ill., graph. Darst.
    Series Statement: Undergraduate texts in mathematics
    ISBN: 978-3-319-16721-3 , 978-3-319-16720-6
    Type of Medium: Book
    Language: English
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  • 6
    Unknown
    Washington, D.C : Brookings Institution Press
    Keywords: Old age pensions, Government policy, United States, Congresses. ; Old age pensions, United States, Congresses. ; Pension trusts, United States, Congresses. ; Retirement income, Government policy, United States, Congresses. ; Social security, United States, Congresses.
    Notes: The transition to hybrid pensions plans in the United States : an empirical analysis / Robert L. Clark and Sylvester J. Schieber -- What people don't know about their pensions and Social Security / Alan L. Gustman and Thomas L. Steinmeier -- Financial education and private pensions / Dean M. Maki -- Life-cycle saving, limits on contributions to DC pension plans, and lifetime tax benefits / Jagadeesh Gokhale, Laurence J. Kotlikoff, and Mark J. Warshawsky -- The effects of Social Security reform on private pensions / Andrew A. Samwick -- Pension choices with uncertain tax policy / Joel M. Dickson -- The design and cost of pension guarantees / Kent Smetters -- Effects of nondiscrimination rules on pension participation / Robert L. Clark, Janemarie Mulvey, and Sylvester J. Schieber -- Asset location for retirement savers / James M. Poterba, John B. Shoven, and Clemens Sialm -- Longevity-insured retirement distributions from pension plans : market and regulatory issues / Jeffrey R. Brown and Mark J. Warshawsky
    Pages: viii, 406 p.
    ISBN: 0-8157-9642-0
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  • 7
    Keywords: Indonesia, Armed Forces, Political activity. ; Indonesia, Armed Forces, Reorganization. ; Indonesia, Military relations, United States. ; Indonesia, Politics and government, 20th century. ; United States, Military relations, Indonesia. ; Civil-military relations, Indonesia.
    Pages: xxvi, 157 p.
    ISBN: 0-8330-3402-2
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  • 8
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Marked abnormalities of the magnetic resonance intensity of N-acetylaspartate (NAA) have been reported in patients with various neurological disorders, but the neurochemical consequences of these alterations are difficult to assess because the function of NAA remains speculative. The purpose of this study was to examine whether NAA plays a role in protecting neurons against osmotic stress. Intracerebral microdialysis was used to expose a small region of the rat dorsolateral striatum to an increasingly hyposmotic environment and to measure resulting changes in NAA extracellular concentrations. NAA changes in the extracellular fluid (ECF) were compared with those of the amino acids, in particular, taurine, known to be involved in brain osmoregulation. Stepped increases in cellular hydration produced by hyposmotic perfusion media induced a marked increase in ECF NAA, reflecting a redistribution of NAA from intra-to extracellular space. Parallel experiments showed that, of all the extracellular amino acids measured, only taurine markedly increased with hyposmolar perfusion medium, indicating that the ECF NAA increase associated with hyposmotic stress was a specific response and not passive leakage out of the cells. As NAA is predominantly neuronal, it may contribute to the protection of neurons against swelling (i.e., regulatory volume decrease). In conditions with impaired blood-brain barrier and cytotoxic oedema, efflux of intracellular NAA subsequent to sustained cellular swelling might lead to a reduction in total brain NAA detectable by magnetic resonance spectroscopy. Alternatively, redistribution of NAA from intra-to extracellular space implies changes in its chemical environment that may alter its magnetic resonance visibility.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: In this study we have examined (1) the integrated function of the mitochondrial respiratory chain by polarographic measurements and (2) the activities of the respiratory chain complexes I, II–III, and IV as well as the ATP synthase (complex V) in free mitochondria and synaptosomes isolated from gerbil brain, after a 30-min period of graded cerebral ischaemia. These data have been correlated with cerebral blood flow (CBF) values as measured by the hydrogen clearance technique. Integrated functioning of the mitochondrial respiratory chain, using both NAD-linked and FAD-linked substrates, was initially affected at CBF values of ∼35 ml 100 g−1 min−1, and declined further as the CBF was reduced. The individual mitochondrial respiratory chain complexes, however, showed differences in sensitivity to graded cerebral ischaemia. Complex I activities decreased sharply at blood flows below ∼30 ml 100 g−1 min−1 (mitochondria and synaptosomes) and complex II–III activities decreased at blood flows below 20 ml 100 g−1 min−1 (mitochondria) and 35–30 ml 100 g−1 min−1 (synaptosomes). Activities declined further as CBF was reduced below these levels. Complex V activity was significantly affected only when the blood flow was reduced below 15–10 ml 100 g−1 min−1 (mitochondria and synaptosomes). In contrast, complex IV activity was unaffected by graded cerebral ischaemia, even at very low CBF levels.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 55 (1990), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We studied the binding of [18F]GBR 13119 {1-[[(4-[18F]fluorophenyl) (phenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine} to rat brain with autoradiography after intravenous injection. The rank order of binding was dorsal striatum 〉 nucleus accumbens = olfactory tubercle 〉 sub-stantia nigra = ventral tegmental area 〉 other areas. Binding was blocked by prior injection of dopamine uptake blockers but not by injection of dopamine receptor antagonists or drugs that bind to the dialkylpiperazine site. Unilateral 6-hydroxy dopamine lesions of dopamine neurons caused a marked decrease in striatal and nigral binding on the side of the lesion. We conclude that intravenous injection of [18F]GBR 13119 provides a useful marker of presynaptic dopamine uptake sites.
    Type of Medium: Electronic Resource
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