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  • 1
    Electronic Resource
    Electronic Resource
    Ultrasound, computed tomography and endoscopic retrograde cholangiopancreatography in the morphologic diagnosis of pancreatic disease (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 291-296 
    Details
    ISSN: 1432-1440
    Keywords: Ultrasound ; Computed tomography ; Endoscopic retrograde cholangiopancreatography ; Chronic pancreatitis ; Pancreatic tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary From February to November 1981 the diagnostic relevance of ultrasound (US), computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP) was compared prospectively in 75 patients with suspected pancreatic disease. Final diagnosis was confirmed by autopsy, surgery, clinical course, and further laboratory data. Thus it was possible to exclude pancreatic disorders in 32 patients. By ERCP we diagnosed all tumors; sensitivity was 100%. Sensitivity of US and CT were 63% each. In five cases US made the false positive diagnosis” pancreatic malignant tumor” (specifity 93%), CT and ERCP in two cases (specifity 97% each). In chronic pancreatitis specifity of US and ERCP were 100% and specifity of CT was 98%. Sensitivity of ERCP amounted to 93%, CT and US revealed 74% and 52%, respectively. We conclude that ERCP is the best morphologic diagnostic tool in differentiating chronic pancreatitis from pancreatic carcinoma. US is a good screening method and CT reveals good diagnostic results in acute pancreatitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01497778
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Der orale Pankreasfunktionstest mit FDL in der Diagnose der chronischen Pankreatitis (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 193-198 
    Details
    ISSN: 1432-1440
    Keywords: Pancreolauryltest (PLT) ; Sensitivity ; Specificity ; Chronic pancreatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The diagnostic accuracy of a tubeless pancreatic function test — Pancreolauryl (PLT) — was evaluated on 97 patients and healthy controls: we found a pathological result of PLT in 31 (88,6%) of 35 patients with proven chronic pancreatitis and a normal PLT in 30 (90%) of 33 controls with no pancreatic disease. In 29 patients with a defined gastrointestinal disease other than chronic pancreatitis the test result was pathological in 51%. This result points towards a limited specifity of the PLT in this latter group, but shows its usefulness as an indicator for maldigestion accompanying the primary disease. In comparison to firmly established diagnostic means for chronic pancreatitis the PLT result was in accordance with the Secretin-Ceruletide function test in 81,3% with ERCP in 80,9% and with computertomography in 76,4%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01488974
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Hemmung von Fibroblastenkulturen durch D-Penicillamin (1974)
    Springer
    Journal of molecular medicine 52 (1974), S. 794-796 
    Details
    ISSN: 1432-1440
    Keywords: D-Penicillamine ; fibroblast cultures ; thymidine uptake ; leucine uptake ; D-Penicillamin ; Fibroblastenkulturen ; Thymidineinbau ; Leucineinbau
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung D-Penicillamin (D-PA) hemmt dosisabhängig in Fibroblastenkulturen die Anfnahme von3H-Thymidin und3H-Leucin sowie die Zellproliferation. Die Hemmung des Fibroblastenstoffwechsels und der Zellvermehrung ist bei Konzentrationen von 1,0 mg D-PA/ml und darunter reversibel. Aus den vorliegenden Befunden kann geschlossen werden, daß D-PA mesenchymsuppressiv wirkt nicht nur durch eine Störung der Kollagenquervernetzung, sondern auch durch Hemmung der Fibroblasten.
    Notes: Summary D-Penicillamine (D-PA) inhibited dose-related the uptake of3H-thymidine and3H-leucine as well as the cell proliferation in fibroblast cultures. The inhibition is reversible for D-PA-concentrations of 1,0 mg/ml and less. These data suggest that D-PA depresses mesenchymal reactions not only by inducing abnormalities in the cross-linking of collagen but also by inhibition of the fibroblasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468741
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The effect of an immunosuppressive drug (azathioprine) on the latent infection of marmoset monkeys (Callithrix jacchus) with the oncogenicHerpesvirus saimiri (1975)
    Springer
    Medical microbiology and immunology 161 (1975), S. 171-174 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Callithrix jacchus (CJ) marmoset monkeys can be latently infected withHerpesvirus saimiri (HVS). In order to determine whether this resistance to the oncogenic potential of HVS could be due to the immune surveillance, azathioprine, a known immunosuppressive drug, was given to 7 latently infected CJ marmosets. The animals died within 147 days probably from side effects caused by azathioprine, but no animal developed a tumor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02121007
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    Paper (German National Licenses)
    Fulltext
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