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  • 1
    ISSN: 1432-1084
    Keywords: Key words: Ovarian cancer ; Lesion characterization ; Recurrence ; PET ; CT ; MRI
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The aim of this study was to compare prospectively the accuracy of whole-body positron emission tomography (PET), CT and MRI in diagnosing primary and recurrent ovarian cancer. Nineteen patients (age range 23–76 years) were recruited with suspicious ovarian lesions at presentation (n = 8) or follow-up for recurrence (n = 11). All patients were scheduled for laparotomy and histological confirmation. Whole-body PET with FDG, contrast-enhanced spiral CT of the abdomen, including the pelvis, and MRI of the entire abdomen were performed. Each imaging study was evaluated separately. Imaging findings were correlated with histopathological diagnosis. The sensitivity, specificity and accuracy for lesion characterization in patients with suspicious ovarian lesions (n = 7) were, respectively: 100, 67 and 86 % for PET; 100, 67 and 86 % for CT; and 100, 100 and 100 % for MRI. For the diagnosis of recurrent disease (n = 10), PET had a sensitivity of 100 %, specificity of 50 % and accuracy of 90 %. The PET technique was the only technique which correctly identified a single transverse colon metastasis. Results for CT were 40, 50 and 43 %, and for MRI 86, 100 and 89 %, respectively. No statistically significant difference was seen. Neither FDG PET nor CT nor MRI can replace surgery in the detection of microscopic peritoneal disease. No statistically significant difference was observed for the investigated imaging modalities with regard to lesion characterization or detection of recurrent disease; thus, the methods are permissible alternatives. The PET technique, however, has the drawback of less accurate spatial assignment of small lesions compared with CT and MRI.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1433-3023
    Keywords: Female urinary incontinence ; Lower urinary tract ; Ultrasound
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion Ultrasound is a complementary evaluation for the study of female urinary incontinence which allows functionalmorphological documentation. A reliable urogynecologic examination is based on the patient's history, clinical evaluation, urodynamics and imaging. Training in sonography of the female lower urinary tract should be performed within the scope of urogynecological evaluations.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0711
    Keywords: Photodynamic therapy ; Photosensitizers ; m-THPC ; Breast cancer ; In vitro ; Adenosine triphosphate cell viability assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Photodynamic therapy (PDT) might be of clinical value for patients with breast cancer with local recurrences or metastasis. However, there is a need for improved photosensitizers that are effective in combination with laser light and have few, if any, side-effects. We evaluated in vitro the effectiveness of a second generation photosensitizer by testing the influence of laser light on cell cultures of a human breast carcinoma cell line, incubated with meta-tetrahydroxy-phenylchlorin (m-THPC) (=Temoporfin®).Experimental design: Five thousand MCF-7 cells were plated in 96-well plates. Forty-eight hours before laser treatment, the cells were plated to achieve a monolayer configuration. Twenty-four hours after plating, they were incubated with m-THPC. On day 6 after treatment with m-THPC we lysed the cells to extract the intracellular ATP that correlates with the number of living cells. The ATP-CVA was used to assess the cytotoxicity of the tested photosensitizer m-THPC at various concentrations and the relevant laser light alone prior to their combination after six days of culture.Results: We found a dose-response for m-THPC alone ranging from 2 to 16 μg/ml. The calculated inhibition concentration to produce 50% cell kill (IC50) was 4.55 μg/ml. We also observed a very low cytotoxicity for laser irradiation alone but a very strong cell kill for the combination of m-THPC together with laser light.Conclusions: PDT gave almost total cell kill at m-THPC concentrations that are not toxic in vitro.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0711
    Keywords: Key words: Photodynamic therapy ; Photosensitizers ; m-THPC ; Breast cancer ; In vitro ; Adenosine triphosphate cell viability assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract.  Background: Photodynamic therapy (PDT) might be of clinical value for patients with breast cancer with local recurrences or metastasis. However, there is a need for improved photosensitizers that are effective in combination with laser light and have few, if any, side-effects. We evaluated in vitro the effectiveness of a second generation photosensitizer by testing the influence of laser light on cell cultures of a human breast carcinoma cell line, incubated with meta-tetrahydroxyphenylchlorin (m-THPC) (=Temoporfin®). Experimental design: Five thousand MCF-7 cells were plated in 96-well plates. Forty-eight hours before laser treatment, the cells were plated to achieve a monolayer configuration. Twenty-four hours after plating, they were incubated with m-THPC. On day 6 after treatment with m-THPC we lysed the cells to extract the intracellular ATP that correlates with the number of living cells. The ATP-CVA was used to assess the cytotoxicity of the tested photosensitizer m-THPC at various concentrations and the relevant laser light alone prior to their combination after six days of culture. Results: We found a dose-response for m-THPC alone ranging from 2 to 16 µg/ml. The calculated inhibition concentration to produce 50% cell kill (IC50) was 4.55 µg/ml. We also observed a very low cytotoxicity for laser irradiation alone but a very strong cell kill for the combination of m-THPC together with laser light. Conclusions: PDT gave almost total cell kill at m-THPC concentrations that are not toxic in vitro.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Archives of gynecology and obstetrics 249 (1991), S. 87-93 
    ISSN: 1432-0711
    Keywords: Long-term survival ; Stage III and IV ovarian cancer ; Radical surgery
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 104 unselected, previously untreated patients with invasive stage III or IV ovarian cancer were operated on between 1977 and 1984. Nine patients were lost in follow-up, three died from non-malignant disease. Thirteen of the 92 eligible patients (15%) were observed to survive 5 years or longer. In the 13 long-term survivors, 4 had stage IV disease, 7 positive peritoneal cytology, 3 bowel resection, and 12 residual disease 〈2 cm after primary surgery. Retroperitoneal lymph nodes were involved in 6/9 cases. The majority of 5-year survivors (69%) received cis-platin-containing combination chemotherapy. 5/7 long-term survivors had positive second-look. At 5 years, life-quality in 9/13 patients who were free of disease, was high. It can be concluded that only patients with optimally resected stage III or IV ovarian cancer have a realistic chance of long-term survival. It is expected that increasing radicality in surgery for ovarian cancer together with platinum-based chemotherapy regimens may improve long-term survival in the future. In addition, further studies of new chemotherapeutic approaches are needed.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Trophoblast ; „Placental site trophoblastic tumor“ ; „Exaggerated placental site“ ; „Placental site nodule“ ; Zytokeratin ; β -HCG ; HPL ; Key words Placental ; Site trophoblastic tumors ; Exaggerated placental site ; Placental-site nodule ; Sytokeratin ; β -Human chorionic gonadotrophin ; Human placental lactogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A placental-site trophoblastic tumor is a rare neoplasia that is derived from the cells of the intermediate trophoblast. Morphological, biochemical, and Doppler ultrasound findings are presented regarding differential diagnosis using material from three recent cases. Essentially, placental-site trophoblastic tumors can be diagnosed if infiltration of the myometrium is seen by a monomorphic trophoblastic proliferation that is not interrupted by decidual cells. Necrosis and hemorrhages are not features of placental-site trophoblastic tumors. However, there is a peculiar behavior towards the uterine vasculature as spiral arteries are dilated and transformed the same way as occurs at the site of physiological implantation of pregnancy. It appears that as a result of this phenomenon there is a characteristic finding in ultrasound. Examination of this type of tumor demonstrates cystic spaces that can be defined as blood vessels by their Doppler signal. In two of the three cases a hysterectomy was performed, and criteria for the assumption of malignant placental-site tumors are therefore presented. However, only the mitosis rate seems to possess some predictive value.
    Notes: Zusammenfassung Beim „placental site trophoblastic tumor“ handelt es sich um eine seltene Neoplasie, die aus den Zellen des sog. intermediären Trophoblasten entsteht. Die vorliegende Arbeit präsentiert morphologische, laborchemische und dopplersonographische Befunde zur Differentialdiagnose anhand von 3 kürzlich beobachteten Fällen. Wesentlich für die Annahme eines „placental site trophoblastic tumor“ ist der Nachweis einer Infiltration des Myometriums durch eine monomorphe trophoblastäre Zellpopulation, die nicht von dezidualen Zellen unterbrochen wird. Nekrosen und Hämorrhagien größeren Ausmaßes fehlen im Bereich des infiltrativen Wachstums; stattdessen kommt die Umgestaltung und Aufweitung mütterlicher Spiralarterien zur Beobachtung, wie sie für die physiologische Implantationsregion bekannt ist. Aus diesem Phänomen scheint ein charakteristischer Ultraschallbefund zu resultieren: in der Uteruswand gelegene zystischen Herde weisen dopplersonographisch einen gefäßtypischen Blutfluß auf. Da in 2 Fällen anschließend der Uterus zur Untersuchung kam, werden auch Kriterien zur Annahme eines malignen Verhaltens des Tumors vorgestellt. Morphologisch scheint nur die Mitoserate in der Läsion einen gewissen prädiktiven Wert zu besitzen.
    Type of Medium: Electronic Resource
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