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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 131 (1994), S. 157-159 
    ISSN: 0942-0940
    Keywords: Pituitary adenoma ; Cushing's disease, inferior petrosal sinus sampling (IPSS) ; Raymond's syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Inferior petrosal sinus sampling (IPSS) is used to evaluate the pituitary-dependency of Cushing's disease, and to predict the laterality of a microadenoma prior to transsphenoidal operation. A serious complication occured in a 14-year-old boy: he suffered brain stem ischaemia with abducens nerve palsy and hemiparesis (Raymond's syndrome). The case prompted us to reconsider the indication for this investigation.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  · Background: A study was carried out to evaluate the potential suitability of a free-running erbium:YAG 2.94-µm laser for trephination of human corneas in penetrating keratoplasty. · Methods: Two human donor corneas were placed in an artificial anterior chamber and moved with an automated rotation device (one rotation per minute). An erbium:YAG laser beam (pulse duration 400 µs, repetition rate 2/s, energy density 2.5 and 15.0 J/cm2) was focused on the outer edge of a round ceramic mask placed on the human donor corneas for ablation of tissue. · Results: With a fluence of 15.0 J/cm2, perforation was achieved after 500 pulses. Perpendicular central cut edges with mild stromal ridges and, by light microscopy, a 12 to 45-µm area of stromal thermal effects and focal endothelial changes up to 200 µm central to trephination were observed. · Conclusions: The erbium:YAG laser could be a promising ”low-cost alternative” to the excimer laser for nonmechanical trephination in penetrating keratoplasty. Further studies will have to focus on reduction of thermal damage and on wound healing.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Graefe's archive for clinical and experimental ophthalmology 236 (1998), S. 426-433 
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  · Background: The purpose of this study was to quantify blood-ocular barrier impairment by measuring aqueous flare in retinitis pigmentosa (RP) and to search for clinical correlations. · Methods: Forty-nine patients (94 eyes) with RP and 85 normal controls were examined. Aqueous flare was quantified with the noninvasive laser flare-cell meter (FC-1000, Kowa, Japan). Degrees of cystoid macular edema (CME), vitreous pigment dusting (VPD), intraretinal migration of retinal pigment epithelium, and waxy pallor of the optic nerve head were determined semiquantitatively by biomicroscopy. Data were analyzed using the t-test the Mann-Whitney U-test, the chi-squared test and regression analysis by taking into account the dependency of data from two eyes of the same patients. · Results: Aqueous flare (photon counts/ms) was significantly higher in RP (mean 10.11±3.53) than in normals (3.89±0.94; P〈0.001). Clinically significant CME was present in 26% of eyes with RP, being significantly more frequent in autosomal dominant RP (11 of 16 eyes, 69%) than in other variants (17%; P〈0.005). Multivariate analysis revealed that CME was most strongly associated with flare values (r=0.84, P〈0.01), whereas – after adjusting for CME – correlations between aqueous flare and other clinical findings did not reach significance. · Conclusion: RP eyes show increased aqueous flare values, indicating impairment of blood-ocur barriers. This appears to be associated with CME and with autosomal dominant RP.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Purpose: Thermal effects on the laser aperture mask may play a major role in the thermal loading of the cornea during nonmechanical trephination in penetrating keratoplasty. The purpose of this study was to assess the temperature increase on the laser mask using the 2.94-µm Er:YAG laser in order to find suitable parameters for avoidance of thermal damage to the cornea. Methods: Thermal load measurements were performed on donor (7.5 mm trephination diameter, 0.7 mm thickness, central hole 3.0 mm) and recipient (7.5 mm trephination diameter, 0.7 mm thickness, outer diameter 13.0 mm) aperture masks. The masks were either mounted on a thermal isolator or fixed directly on porcine corneal samples. Temperature increase was measured either under static conditions in the ablation area (setup 1) and at the opposite side of the mask (setup 2) or in the ablation area under dynamic conditions, rotating the whole globe to simulate a constant trephination speed with the mask positioned directly on a porcine cornea (setup 3). We used the NWL Er:YAG solid-state laser in a 1.3-mm free-running spot mode focused on the trephination margin (half of the beam on the mask and half of it on the cornea) with a pulse energy of 200 or 400 mJ and 18CrNi10 stainless steel versus three different types of ceramic masks (silicium carbide, silicium nitrite, aluminum oxide). Temperature was assessed using an infrared pyrometer with automatic data acquisition software for a personal computer. Results: Overall, the temperature rise ranged between 43.6 K (metal donor mask at the trephination area with 400 mJ pulse energy) and 3.3 K (silicium carbide recipient mask at the opposite side of the mask with 200 mJ pulse energy). With all setups and both energy levels, the heating of the metal mask was significantly higher (P〈0.02) than the heating of the three types of ceramic masks. The silicium carbide masks revealed the lowest temperature rise. Comparing the three setups, the temperature rise was maximal under static conditions in the ablation area and minimal at the opposite side, with the dynamic setup ranging in between. Temperature rise was significantly greater (P〈0.04) in donor masks than in recipient masks for each mask material and both energy levels. Conclusion: The physical characteristics of silicium carbide masks seem superior to those of metal masks with regard to minimizing the thermal load of the epithelium or superficial stroma during Er:YAG laser trephination of the cornea for penetrating keratoplasty.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Graefe's archive for clinical and experimental ophthalmology 238 (2000), S. 642-646 
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Background: Photorefrative keratectomy can be used to flatten the curvature of the anterior cornea and reduce the myopic refraction of the eye. This leads to un-physiological topographical changes of the cornea and may alter the conditions for examinations of corneal surface topography. The purpose of this study was to check for mutual agreement of three different methods of assessment of astigmatism before and after myopic photorefractive keratectomy (PRK). Patients and methods: Forty-seven eyes of 28 patients (age 32.7±6.6 years) following PRK using an 193-nm excimer laser were included in this study. 37 eyes were treated for pure myopia (–4.9±2.4 D) and 10 eyes for myopic astigmatism (sphere –2.0 to –7.0 D, cylinder –1.0 to –3.0 D). Preoperatively and at 18 months postoperatively, subjective refractometry, keratometry and topography analysis were performed. The axes of topographic and keratometric cylinder were standardized periodically (180°) with respect to the refractive cylinder axis. Results: Pre- and postoperatively, the absolute astigmatism values correlated highly significantly between all three methods (P≤0.001). The mean refractive cylinder was 0.65±0.61 D preoperatively and 0.46±0.41 D postoperatively (P=0.2). The mean keratometric astigmatism was 1.14±0.64 D before and 0.94±0.50 D after PRK treatment (P=0.2). Among the three methods, the mean topographic astigmatism was the highest (P〈0.001) preoperatively (1.31±0.56 D) and postoperatively (1.21±0.52 D) (P=0.3). In eyes treated for pure myopia, no difference between pre- and postoperative refractive, keratometric and topographic astigmatism was detected (P〉0.5). The axes of both topogra-phic and keratometric astigmatism correlated highly significantly with the refractive cylinder axis (R≥30.9, P〈0.0001). Conclusion: Up to 2 years after myopic PRK, the difference between refractive and keratometric astigmatism does not differ from the preoperative value, indicating an even corneal surface. The absolute astigmatism values and the cylinder axis correlated well between subjective and objective methods of astigmatism assessment. Thus, objective measurements may be helpful in determining the cylinder component of best spectacle correction after PRK. However, topographic analysis overestimates astigmatism values systematically before and after PRK.
    Type of Medium: Electronic Resource
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