ISSN:
1432-0428
Keywords:
Sucrose-diet
;
streptozotocin-diabetes
;
retinopathy
;
rats
;
trypsin digests
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Normal and streptozotocin-diabetic rats have been maintained for 6–11 months on completely balanced, reconstituted diets in which the sole source of carbohydrate was either 68% corn starch or 68% sucrose. The retinal vascular system was isolated by trypsin digestion and examined histologically for the presence of tortuosity and irregularity of capillary diameter, increased PAS-positive deposits, microaneurysms, loss of pericytes, endothelial proliferation, acellularity and strand formation. None of these pathological changes occurred in normal rats fed a starch-rich diet, but all developed to a similar extent in the sucrose-fed normal rats and the starch-fed diabetic group. The changes were more severe in sucrose-fed diabetic rats after 6 months. In all groups the retinopathy progressed with time. The possibility that a factor common to both the ingestion of a sucrose-rich diet and streptozotocin diabetes in rats has been considered since, histologically, the retinopathy observed was identical both with respect to severity and rate of development in normoglycaemic, sucrose-fed and hyperglycaemic, starch-fed diabetic rats.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00420981
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