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  • 1
    Electronic Resource
    Electronic Resource
    Flush induced by fluoroquinolones in canine skin (1995)
    Springer
    Inflammation research 44 (1995), S. 461-465 
    Details
    ISSN: 1420-908X
    Keywords: Quinolone ; Flush ; Redness ; Dog ; Histamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The flush induced by two fluoroquinolone antibacterial agents, balofloxacin and ofloxacin, was studied in beagle dogs. Intradermal injection of the fluoroquinolones at concentrations above 10−5M produced a localized flushed area. The flush responses to fluoroquinolones were inhibited by co-administration with H2-antagonist(s) (ranitidine or cimetidine), but not with H1-antagonist(s) (mepyramine or chlorpheniramine). Similar inhibitory effects of these H2-antagonists were observed for the response to histamine. The flush responses to fluoroquinolones were inhibited by a local pretreatment with compound 48/80 administered to deplete the local stores of mast cell-bound histamine. When the fluoroquinolones were orally administered at a dose of 400 mg/kg, the concentration of histamine in plasma was increased, being accompanied by systemic erythema. These results indicate that the flush induced by fluoroquinolones is mediated by histamine release from canine cutaneous mast cells and H2-receptor stimulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01837910
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Changes in intracranial pressure (ICP) pulse wave following hydrocephalus (1986)
    Springer
    Acta neurochirurgica 82 (1986), S. 50-56 
    Details
    ISSN: 0942-0940
    Keywords: Pulse pressure ; intracranial pressure pulse wave ; elastance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The pulse pressure (PP) of the intracranial pressure pulse wave (ICPPW) was measured in experimental and clinical hydrocephalus: namely, obstructive and kaolin-induced hydrocephalus as an experimental study, and noncommunicating and communicating hydrocephalus as a clinical study. At approximately the same ICP level, the PP was much higher in the obstructive hydrocephalus group and slightly higher in the kaolin-induced hydrocephalus group than in the controls. Also the PP level in noncommunicating hydrocephalus patients [3.19mm Hg (SD: 1.04)] was significantly (P〈0.05) higher than that in the communicating hydrocephalus patients [1.88 mm Hg (SD: 0.60)]. The results of our research suggest that the stronger the disturbance of the communication of the CSF between cranial cavity and spinal cavity the higher the PP of ICPPW. This results from the distensibility of the spinal dural sac and exerts a great influence on the elasticity and the PP of the cranial system. It is reasonable, therefore, to suggest that a marked increase in the ratio of the PP to the ICP in the normal or slightly high ICP hydrocephalus may indicate disturbance of the CSF flow, especially loss of CSF communication between the cranial and spinal compartments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01456319
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Separation of double conjugates of bile acids by two-dimensional high-performance thin-layer chromatography with tetra-n-butylammonium phosphate and methyl β-cyclodextrin (1999)
    Springer
    Chromatographia 49 (1999), S. 681-685 
    Details
    ISSN: 1612-1112
    Keywords: Thin-layer chromatography ; 2-Dimensional development ; Bile acid conjugates ; Tetra-n-butylammonium phosphate ; Methyl β-cyclodextrin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary This paper describes a method for the separation, by high-performance thin-layer chromatography (HPTLC), of a series of polar, ionic, and hydrophilic double conjugates of bile acids amidated at the C-24 carboxyl group with glycine or taurine and sulfonated or glucosylated at hydroxyl groups in the 5β-steroid nucleus. The method involves two-dimensional (2D) reversed-phase (RP) HPTLC with the combined use of tetra-n-butylammonium phosphate (TBAP) and methyl β-cyclodextrin (Me-β-CD) as mobile phase additives. Complete separation of the hydrophilic bile acid conjugates, particularly of the recalcitrant pairs of chenodeoxycholic acid and deoxycholic acid conjugates in each group, was achieved by 2D inclusion RPHPTLC by developing with methanol-water-0.5 mol L−1 TBAP, 90:10:5–75:25:5 (ν/ν) in the first dimension and the same mobile phase containing 5mm Me-β-CD in the second dimension. The method could be usefully applied to biosynthetic and metabolic studies of bile acids in biological materials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02466912
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    Paper (German National Licenses)
    Fulltext
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