Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Clinical and basic studies on the G-1 column, a new extracorporeal therapeutic device effective in controlling rheumatoid arthritis (1998)
    Springer
    Inflammation research 47 (1998), S. 166-176 
    Details
    ISSN: 1420-908X
    Keywords: Key words: G-1 column — Extracorporeal perfusion — Rheumatoid arthritis — Granulocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The G-1 column, which is filled with cellulose acetate spherical beads of 2 mm diameter, is a new type of extracorporeal perfusion device originally designed to remove granulocytes from the venous circulation of patients with rheumatoid arthritis. A dramatic improvement in clinical symptoms was seen after treatment with the G-1 column in two successive clinical trials. Early effects include pain relief, reduction in the swollen joints, and a continued decrease in inflammation as a late effect. The results were further confirmed in the adjuvant arthritic rat model. G-1 beads adsorb some amounts of platelets at the beginning and then about a quarter of circulating neutrophils, monocytes, natural killer cells, and B cells, but not T cells. Various factors released from blood cells during transit through the column must have influenced the cells including lymphocytes which passed through the column. G-1 column actually eliminates some parts of aggressive leukocytes, but a more interesting story is the modification of blood components, which occurred in the G-1 column, and when returned to the patients, may have ameliorated the unbalanced homeostatic network and induced acceleration of healing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000110050311
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Properties of vascular permeability factor in human sera for guinea-pig skin (1979)
    Springer
    Cellular and molecular life sciences 35 (1979), S. 676-678 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Properties of vascular permeability factor in native human sera (PF/Nat) showed close similarities with those of necrotizing factor. Time course studies revealed that skin necrosis could be initiated by enhanced vascular permeability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01960394
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Suppressive Effect of Prostaglandin E1 on Pulmonary Hypertension Induced by Monocrotaline in Rats (1999)
    Springer
    Lung 177 (1999), S. 77-88 
    Details
    ISSN: 1432-1750
    Keywords: Key words: Monocrotaline—Pulmonary hypertension—Prostaglandin E1—Cytokine—Ca2+ influx.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The effect of administering prostaglandin E1 (PGE1) on the extent of monocrotaline (MCT)-induced pulmonary hypertension and cytokine production [interleukins (IL) 1 and 6 and tumor necrosis factor (TNF)] by macrophages during MCT induction of pulmonary hypertension was studied. Right ventricle/left ventricle plus septum weight ratios (RV/LV + S) were used as an index of the development of pulmonary hypertension. Administering PGE1 at a dose of 0.2 mg/kg/day for 4 weeks reduced significantly the RV/LV + S ratio from 0.428 ± 0.070 to 0.243 ± 0.059 (p 〈 0.01) and decreased the production of these cytokines: IL-1, from 4.675 ± 3.558 to 1.800 ± 0.722 units; IL-6, from 0.322 ± 0.121 to 0.060 ± 0.039 units; and TNF, from 0.578 ± 0.369 to 0.004 ± 0.004 units. In another series of experiments, a significant reduction of the RV/LV + S ratio was noted for only 1 week when we administered PGE1 immediately after the injection of MCT. We confirmed that histopathologic improvements of lungs were noted by administering 0.2 mg/kg PGE1 for 4 weeks. In another experiment, PGE1 at a concentration of 2 μg/ml suppressed a rise in the cytosolic Ca2+ concentration of lipopolysaccharide-stimulated peritoneal macrophages of rats in vitro, suggesting that PGE1 suppressed cytokine production by macrophages through the suppression of the Ca2+ influx. These results suggest that administering PGE1 may be effective in the treatment of some forms of pulmonary hypertension in humans.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00007632
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Development of Monocrotaline-Induced Pulmonary Hypertension Is Attenuated by a Serotonin Receptor Antagonist (2000)
    Springer
    Lung 178 (2000), S. 63-73 
    Details
    ISSN: 1432-1750
    Keywords: Key words: Pulmonary hypertension—Serotonin receptor antagonist—Monocrotaline—Proliferating cell nuclear antigen.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The significance of serotonin in the pathogenesis of monocrotaline-induced pulmonary hypertension (MCT-PH) in rats, plasma serotonin concentrations, and the effect of a serotonin receptor antagonist administration in association with the number of proliferative cells were investigated. The thickness of the media of the small pulmonary arteries and the weight ratio of the RV to that of LV + S (RV/[LV + S] weight ratio) were used as indices of the severity of PH. Plasma serotonin concentrations were measured by high-performance liquid chromatography. Histopathologic analysis of the lung tissue was performed by hematoxylin-eosin and elastin van Gieson staining. Immunohistopathologic staining for proliferating cell nuclear antigen (PCNA) was performed to identify proliferative cells. The severity of PH as determined by the medial thickness of the small pulmonary arteries and RV/(LV + S) weight ratio in rats with MCT-PH was significantly reduced after treatment with MCI-9042 (p 〈 0.01 and p 〈 0.05, respectively). The serotonin concentration was significantly greater in MCT-PH rats than in normal control rats (p 〈 0.05). The scores for histopathologic changes, such as thickening of the alveolar walls and interstitial inflammatory cell infiltration in MCT-PH rats, were significantly reduced after treatment with MCI-9042 (p 〈 0.05 and p 〈 0.01, respectively). The number of PCNA-positive cells was significantly greater in MCT-PH rats than in normal control rats (p 〈 0.0001) and was reduced after treatment with MCI-9042 (p 〈 0.0001). Treatment with MCI-9042 significantly inhibited the development of MCT-PH along with a decrease in the number of PCNA-positive cells, suggesting a pivotal role of serotonin in the development of PH induced by MCT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004080000009
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Pulmonary hypertension in MCTD: Report of two cases with anticardiolipin antibody (1992)
    Springer
    Clinical rheumatology 11 (1992), S. 195-201 
    Details
    ISSN: 1434-9949
    Keywords: Pulmonary Hypertension ; Anticardiolipin Antibody ; Mixed Connective Tissue Disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report on 2 patients with well-documented mixed connective tissue disease (MCTD) accompanied by severe pulmonary hypertension (PH) due to thrombosis or thromboembolism. In a previous report we indicated (1) that patients with MCTD complicated by PH have a significantly worse prognosis than patients with other connective tissue disease (CTD) complicated by PH. Both our patients had anticardiolipin antibody (a-CL) in the initial stages of the disease. We also studied the relationship of a-CL to PH in patients with other CTD. Patients of either MCTD or SLE with high levels of a-CL had significantly higher values of mean pulmonary arterial pressure than patients without a-CL. Several factors were suggested for the pathogenesis of PH such as vasospasm, arteritis, platelet dysfunction, and thrombosis or thromboembolism. The presence of a-CL may be one of important factors in development of PH among patients with MCTD with recurrent pulmonary thrombosis or thromboembolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02207956
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    An investigation on rheumatoid factor of different immunoglobulin classes in hepatitis B virus crriers (1991)
    Springer
    Clinical rheumatology 10 (1991), S. 31-37 
    Details
    ISSN: 1434-9949
    Keywords: Hepatitis B Virus Carrier ; Isotypes of Rheumatoid Factor ; ELISA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rheumatoid factor (RF) is known to be present very frequently in HB virus carriers. When RF was assayed in 140 asymptomatic carriers by agglutination method, 20.0% were found to be positive, whereas 2.7% in the controls (p〈0.01). ELISA for detection of RF isotypes showed RF in carriers to be almost IgMRF only. IgMRF showed a tendency to react more readily to human IgG rather than to rabbit IgG. The incidence of IgMRF positivity was higher among anti-HBe antibody-positive carriers than among anti-HBe antibody negative ones, but the difference between the two populations was not significant. However, the incidence of IgMRF positivity in the group showing hepatic dysfunctions was found to be significantly higher than in the group with normal hepatic functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02208030
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Immunoglobulin class of rheumatoid factors detected by enzyme-linked immunosorbent assay (1983)
    Springer
    Clinical rheumatology 2 (1983), S. 145-151 
    Details
    ISSN: 1434-9949
    Keywords: IgG-Rheumatoid factor ; IgA-Rheumatoid factor ; Enzyme Immunoassay ; Rheumatic Diseases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The immunoglobulin class of rheumatoid factor (RF) in sera and synovial fluids of patients with rheumatic diseases was measured by a solid-phase enzyme immunoassay. IgG-RF was frequently found in seronegative sera as well as in seropositive sera of rheumatic patients. Titers of IgG-RF were higher in the active phase than in the inactive phase of SLE and showed a correlation to the levels of hypocomplementemia and circulating immune complexes in SLE sera. Titers of IgA-RF were likewise higher in the active-phase of SLE with a correlation to titers of circulating immune complexes. IgA-RF was also found frequently in sera of patients with Sjögren's syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032171
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Antibodies to 65Kd heat-shock protein were elevated in rheumatoid arthritis (1994)
    Springer
    Clinical rheumatology 13 (1994), S. 261-264 
    Details
    ISSN: 1434-9949
    Keywords: Rheumatoid Arthritis ; Heat-Shock Protein ; Mycobacterium Leprae
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Antibodies to 65Kd heat-shock protein (hsp) of mycobacterium leprae were measured by enzyme-linked immunosorbent assay (ELISA) in the three immunoglobulin classes in paired sera and synovial fluids of patients with rheumatoid arthritis (RA). Titers of anti-hsp antibody were expressed by optical density (OD) values for sera or indexes (OD values divided by amounts of immunoglobulin in each class) for synovial fluids and for their paired sera. Indexes of anti-hsp antibody were higher in synovial fluids than those in sera at 15/18 for IgG, 17/18 for IgA and 16/18 for IgM class. These results suggest the participation of anti-hsp antibodies to synovitis in RA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02249023
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    An autopsy case with Good's syndrome and dermatomyositis (1985)
    Springer
    Clinical rheumatology 4 (1985), S. 196-201 
    Details
    ISSN: 1434-9949
    Keywords: Good's Syndrome ; Dermatomyositis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 31-year-old male patient complaining of repeated respiratory infections was revealed to be in an immunodeficient state in both humoral and cellular immunity and accompanied by dermatomyositis which was proved by both clinical and histological findings. Persistent diarrhea followed by colonic bleeding due to multiple ulcers and a severe liver dysfunction seemed to bring him to his death. The autopsy revealed the presence of thymoma of spindel cell type, depleted cells in the systemic lymphatic systems and inflammatory lesions in the muscle, liver, lung, kidney and gastrointestinal tract. This is the first report of Good's syndrome accompanied by dermatomyositis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02032294
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Pulmonary hypertension in connective tissue disease. Clinical analysis of sixty patients in multi-institutional study (1990)
    Springer
    Clinical rheumatology 9 (1990), S. 56-62 
    Details
    ISSN: 1434-9949
    Keywords: Pulmonary Hypertension ; MCTD ; SLE ; PSS ; Anti-nRNP Antibody ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clinical features and prognosis of sixty patients with connective tissue disease accompanied by pulmonary hypertension (PH) (26 MCTD, 20 SLE, and 14 PSS) reported retrospectively by multiinstitutions were compared. Though the obtained data were incomplete and lacking in uniformity, no significant difference in the clinical features among the three diseases were observed except high incidence of pulmonary fibrosis and low% VC in PSS with PH patients. Statistically significant difference, however, was observed between live and dead patients of three diseases gathered in post sternal pain, pulmonary diastolic murmur, right ventricular hypertrophy on ECG and mean pressure of pulmonary artery. Higher incidence of anti-nRNP antibody was observed in SLE with PH and PSS with PH patients than with the general population. A quicker occurrence of PH and shorter survival time were observed in MCTD patients with PH than in SLE and PSS patients with PH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02030243
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...