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  • 1
    Electronic Resource
    Electronic Resource
    The Clinical Pharmacology of Propafenone (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 1 (1987), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Propafenone is a potent type Ic antiarrhythmic agent that has activity against a wide variety of supraventricular and ventricular arrhythmias. Clinical administration must be individualized, based on an appreciation of propafenone pharmacokinctics and dose-response relationships, which are quite complex. Although a “therapeutic” plasma concentration is achieved in most patients with 300 mg orally every eight hours and plasma concentrations reach steady state after three days, marked interpatient differences in plasma concentrations occur. In addition, the effective plasma concentration required for arrhythmia suppression varies markedly in individual patients. Oral propafenone is subjected to a marked “first-pass” hepatic elimination via a saturable oxidative pathway. This can result in a tenfold increase in plasma concentrations as the dose is increased from 150 to 450 mg. Accumulation of metabolites, notably 5-OH propafenone, probably contributes to the net antiarrhythmic effect of oral propafenone during chronic oral administration. Propafenone may exacerbate ventricular arrhythmias in 20–15% of patients. This does not appear to be dose-dependent, nor is it associated with a definite prolongation in QT interval.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8167.1987.tb01443.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Metabolites of Cardiac Antiarrhythmic Drugs: Their Clinical Role (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 432 (1984), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1984.tb14510.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    High-performance liquid chromatographic isolation and fast atom bombardment mass spectrometric identification of di-N-desethylamiodarone, a new metabolite of amiodarone in the dog (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 11 (1984), S. 466-471 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Amiodarone is an antiarrhythmic drug which has received considerable attention in recent years. It has been suggested that the unusual pharmacodynamic characteristics of this drug may be due in part to the influence of active metabolites. Using fast atom bombardment (FAB) mass spectrometry we have identified a new metabolite of amiodarone, the di-N-desethyl analog (DDEA). This metabolite was present in the blood of dogs treated with the parent drug, and showed a greater affinity for myocardium than did the parent drug. The unique features of FAB mass spectrometry over electron impact mass spectrometry was an essential element in facilitating the identification of this new metabolite. Whether or not this metabolite has pharmacologic activity or is responsible for some of the side effects occurring during amiodarone administration is not known.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200110906
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    Paper (German National Licenses)
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