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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 36 (1997), S. 59-66 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract A simplified method for the calculation of mammalian cell survival after charged particle irradiation is presented that is based on the track structure model of Scholz and Kraft [1, 2]. Utilizing a modified linear-quadratic relation for the x-ray survival curve, one finds that the model yields linear-quadratic relations also for heavy ion irradiation. If survival is calculated as a function of specific energy, z, in the cell nucleus – thus reducing the stochastic fluctuations of energy deposition – the increase in slope of the survival curve and therefore the coefficient β z can be estimated with sufficient accuracy from the initial slope, α z . This permits the tabulation of the coefficients α z for the particle types and energies of interest, and subsequent fast calculations of survival levels at any point in a mixed particle beam. The complexity of the calculations can thereby be reduced in a wide range of applications, which permits the rapid calculations that are required for treatment planning in heavy ion therapy. The validity of the modified computations is assessed by the comparison with explicit calculations in terms of the original model and with experimental results for track-segment conditions. The model is then used to analyze the influence of beam fragmentation on the biological effect of charged particle beams penetrating to different depths in tissue. In addition, cell-survival rates after neutron irradiation are computed from the slowing-down spectra of secondary charged particles and are compared to experimental observations.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 34 (1995), S. 1-2 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 34 (1995), S. 13-20 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract The risk of radiation-induced cancer is assessed through the follow-up of large cohorts, such as atomic bomb survivors or underground miners who have been occupationally exposed to radon and its decay products. The models relate to the dose, age and time dependence of the excess tumour rates, and they contain parameters that are estimated in terms of maximum likelihood computations. The computations are performed with the software package EPICURE, which contains the two main options of person-by person regression or of Poisson regression with grouped data. The Poisson regression is most frequently employed, but there are certain models that require an excessive number of cells when grouped data are used. One example involves computations that account explicitly for the temporal distribution of continuous exposures, as they occur with underground miners. In past work such models had to be approximated, but it is shown here that they can be treated explicitly in a suitably reformulated person-by person computation of the likelihood. The algorithm uses the familiar partitioning of the log-likelihood into two terms,L 1 andL 0. The first term,L 1, represents the contribution of the ‘events’ (tumours). It needs to be evaluated in the usual way, but constitutes no computational problem. The second term,L 0, represents the event-free periods of observation. It is, in its usual form, unmanageable for large cohorts. However, it can be reduced to a simple form, in which the number of computational steps is independent of cohort size. The method requires less computing time and computer memory, but more importantly it leads to more stable numerical results by obviating the need for grouping the data. The algorithm may be most relevant to radiation risk modelling, but it can facilitate the modelling of failure-time data in general.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 34 (1995), S. 29-35 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract The quantities linear energy transfer or restricted linear energy transfer are utilized in calculations that link absorbed dose to the fluence distribution of a radiation field. The computations provide approximations to absorbed dose in terms of the intermediate quantity cema or reduced cema. With the definition of the restricted linear energy transfer,L Δ, given in ICRU Report 33, the approximation remains imperfect. This study deals with the resulting need for a modified definition ofL Δ, as proposed in a draft report of ICRU. Essential differences between the old and the new definitions are demonstrated. The changed definition permits a rigorous formulation of the dependence between fluence and absorbed dose.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 36 (1997), S. 1-1 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 37 (1998), S. 11-17 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract Lung cancer mortality was analyzed among 4279 nuclear workers of the Mayak facilities in the former Soviet Union, who were exposed to chronic irradiation both externally and internally from incorporated plutonium. The analysis was carried out in terms of a relative risk model. It was shown that an earlier estimate of the excess relative risk for lung cancer, that exceeds the value employed by ICRP by a factor of roughly 2, as well as an earlier estimated latency period of 24 years for lung cancer induction were the result of the numerical procedure chosen. In another recently published case control study, a purely quadratic, threshold-type dose response to incorporated plutonium was deduced. In the present calculations, no evidence for a departure from linearity in dose response was suggested. Principal aim of this study has been the comparison to methods used in the earlier cohort analysis. More detailed risk modelling on the basis of the most recent follow-up will be required.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract The historical development of the dosimetry systems for Hiroshima and Nagasaki is outlined from the time immediately after the A-bomb explosions to the publication of the dosimetry system DS86 in 1987, and the present status of the so-called Hiroshima neutron discrepancy is summarized. Several long-lived radionuclides are discussed with regard to their production by neutrons from the A-bomb explosions. With the exception of 63Ni, these radionuclides have not, up to now, been measured in samples from Hiroshima and Nagasaki. Two of them, 63Ni in copper samples and 39Ar in granite samples, were predominantly produced by fast neutrons. 63Ni can be determined by accelerator mass spectrometry with a gas-filled analyzing magnet. It should be measurable, in the near future, in copper samples up to 1500 m from the hypocenter in Hiroshima. 39Ar can be measured in terms of low-level beta-counting. This should be feasible up to a distance of about 1000 m from the hypocenter. Three radionuclides, 10Be, 14C , and 59Ni, were produced predominantly by thermal neutrons with smaller fractions due to the epithermal and fast neutrons, which contribute increasingly more at larger distances from the hypocenter. State-of-the-art accelerator mass spectrometry is likely to permit the determination of 10Be close to the hypocenter and of 14C up to a distance of about 1000 m. 59Ni should be detectable up to a distance of about 1000 m in terms of accelerator mass spectrometry with a gas-filled magnet. The measurements of 10Be, 14C, 39Ar, 59Ni – and potentially of 131Xe – can be performed in the same granitic sample that was already analyzed for 36Cl, 41Ca, 60Co, 152Eu, and 154Eu. This will provide extensive information on the neutron spectrum at the specified location, and similarly complete analyses can conceivably be performed on granite samples at other locations.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract  Animal experiments have contributed a great deal to our information on effects and risks arising from exposure to radionuclides. This applies, in particular, to alpha-emitting radionuclides where information from man is limited to thorotrast, 224Ra and 226Ra. The late C.W. Mays was the first to suggest that animal data in conjunction with epidemiological data could allow estimates of human risks for radionuclides – predominantly from actinides – where information in man is scarce. The ’International Radiobiology Archives of Long-term Animal Studies’ were created through the combined efforts of European, American and Japanese scientists and aim to safeguard the large amount of existing data on long-term animal experiments and make them available for, among others, an improved assessment of risks from alpha-emitting radionuclides. This paper summarizes the structure of the archives and reviews their present status and future plans. It also demonstrates the extensive information available in these archives on alpha-emitting radionuclides which is suitable for further analysis. Also, the structure of the animal archives could – in a slightly modified form – accommodate the epidemiological data available on 224Ra and thorotrast and, thus, facilitate a direct comparison of data from man, dogs and rodents.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 11 (1974), S. 1-13 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary The linear-quadratic dependence of effect on the dose of ionizing radiation and its biophysical implications are considered. The estimation of the parameters of the response function and the derivation of the joint confidence region of the estimates are described. The method is applied to the induction of pink mutations inTradescantia which follows the linear-quadratic model. The statistical procedure is also suitable for other response functions.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Radiation and environmental biophysics 12 (1975), S. 61-69 
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary This is the first part of an investigation of microdosimetric concepts relevant to numerical calculations. The definitions of the microdosimetric quantities are reviewed and formalized, and some additional conventions are adopted. The common interpretation of the quantities in terms of energy imparted to spherical sites is contrasted with their interpretation as the result of a diffusion process applied to the initial spatial pattern of energy transfers in the irradiated medium.
    Type of Medium: Electronic Resource
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