Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Clinical and experimental dermatology
16 (1991), S. 0
ISSN:
1365-2230
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The clinical value of a very rapid spectrofluorometric method for the determination of plasma uroporphyrin levels was studied during follow-up of 122 patients with porphyria cutanea tarda (PCT). Four-hundred and eight measurements were carried out within a 3-year period. In active PCT plasma uroporphyrin varied between 15 and 448 nmol/1 (normal 0–1.4). A high correlation was seen between elevated levels of uroporphyrin in the plasma and urine in new cases (r=0.72, n= 23) and relapses (r=0.92, n= 37). A parallel course between these variables was noted during the treatment of 31 patients. The correlation was less pronounced (r= 0.42) in remission, i.e. in those cases with urinary uroporphyrin levels lower than 240 nmol/24 h. However, only in nine of 249 measurements taken in remission did plasma uroporphyrin exceed 15 nmol/1. In six of these cases a biochemical relapse had occurred at the next follow-up measurement as judged by an increase of uroporphyrin in the urine. It is suggested that treatment of new cases and relapses should continue until plasma uroporphyrin drops under 10 nmol/1. Values between 15 and 23 nmol/1 in individuals already treated raise the suspicion of relapse and should be rechecked in the near future. Retreatment is necessary when the levels exceed 23 nmol/ 1. The use of the method is recommended as a simple and effective way for monitoring the progress of patients with PCT.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2230.1991.tb00369.x
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