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  • 1
    Electronic Resource
    Electronic Resource
    Importance of picocyanobacteria biomass (unicellular, blue-green algae) in the phytoplankton population of the coastal waters off Japan (1985)
    Springer
    Marine biology 89 (1985), S. 63-69 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Picocyanobacteria, which specifically excited the phycobilin pigments by green light, were numerically counted under an epifluorescence microscope in the Kuroshio and the Oyashio between 1 and 9 July 1983, and in coastal waters between 10 and 12 August 1983 off Japan. The fluorescence, and the various morphological and chemical characters of the picocyanobacteria were evaluated by using monospecific strains isolated from the study area. Plasma volume determined on the epifluorescence microscopic photographs was converted into cellular organic carbon using a relation obtained from the isolates. Percentages of the picocyanobacteria biomass in terms of cellular carbon ranged between 8.3 to 79.4% of the total picophytoplankton (〈3 μm), and between 4.7 to 46.4% of the total phytoplankton. The larger percentages of the picocyanobacteria occurred consistently in low chlorophyll waters.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00392878
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  • 2
    Electronic Resource
    Electronic Resource
    Detection of S-100 protein in melanocytic and neurogenic cutaneous tumors (1984)
    Springer
    Archives of dermatological research 276 (1984), S. 160-164 
    Details
    ISSN: 1432-069X
    Keywords: S-100 Protein ; Melanoma ; Radio-immunoassay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Quantitative determination of S-100 protein content on human melanoma tissues and in sera of melanoma patients was made possible through radioimmunoassay (RIA). Melanoma tissue extracts prepared from metastatic sites in both skin and lymph nodes contained 0.08–2.80% of S-100 out of the total extractable proteins, and it was also noticed that the tumors obtained from lymph-node metastasis possessed slightly higher levels of S-100 as compared with those obtained from the skin lesions. Serum S-100 levels of 12 melanoma patients with Stage 1 to 3 diseases were also examined by means of RIA, but only two patients showed a slight elevation of serum S-100 levels. When tissue sections prepared from a variety of cutaneous tumors, including pigmented nevus, melanoma and Schwannoma, were stained for S-100 by an immunoperoxidase technique, these tumors of neuroectodermal origin were demonstrated to contain a detectable amount of S-100, whereas other tested nonmelanocytic and non-neurogenic tumors were entirely negative for S-100. These data stress the usefulness of S-100 for the diagnosis of neurogenic and melanocytic tumors, especially melanomas, despite the difficulty of its detection in the sera of the tumor bearers, which might reflect the low tendency of S-100 to be shed from the tumor cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414013
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  • 3
    Electronic Resource
    Electronic Resource
    Mitogenic activities for skin fibroblasts in the sera from untreated scleroderma patients at the early stage (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 383-386 
    Details
    ISSN: 1432-069X
    Keywords: Scleroderma ; Nuclear-specific antibodies ; Growth factor ; Platelet-derived growth factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mitogenic activities for adult skin fibroblasts in 17 sera from untreated patients with scleroderma at the early stage were studied. Mitogenic activities in 10% test sera were measured by the [3H]-thymidine incorporation assay using confluent fibroblasts; there was no significnt difference between scleroderma-affected and normal controls. Growth-stimulatory activities for subconfluent fibroblasts in 10% test sera were measured by increased cell numbers; again, there was no significant difference between scleroderma-affected and normal controls. There have been contradictory reports on growth-stimulatory activities in scleroderma sera; our data do not suggest the presence of a specific mitogen in scleroderma sera.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455321
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  • 4
    Electronic Resource
    Electronic Resource
    Acquired growth hormone deficiency due to pituitary stalk transection after head trauma in childhood (1993)
    Springer
    European journal of pediatrics 152 (1993), S. 99-101 
    Details
    ISSN: 1432-1076
    Keywords: Magnetic resonance imaging ; Growth hormone deficiency ; Head trauma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two patients are reported with growth hormone deficiency due to head trauma in childhood. Although their injuries were outwardly only slight and there was no loss of consciousness and no subsequent neurological deficits, they exhibited gradual growth retardation from the time of the trauma. Provocative endocrinological tests showed growth hormone deficiency and MRI showed transection of the pituitary stalk. These findings suggest that ordinary head trauma, as well as perinatal insult and congenital abnormalities, could be a cause of growth hormone deficiency.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02072482
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and β-blocking effects of transdermal timolol (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 493-495 
    Details
    ISSN: 1432-1041
    Keywords: Timolol ; β-adrenoceptor antagonist ; transdermal ; percutaneous absorption ; skin ; pharmacokinetics ; bioavailability ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetic profiles of transdermal timolol 6 and 24 mg (as 5 and 20% w/v patches) was studied in four healthy young volunteers. To assess its bioavailability, the pharmacokinetics of an IV infusion of timolol maleate 5 mg was also determined in the same subjects. When the 20% (w/v) timolol patch was applied, the mean bioavailability was 74.4%. Plasma timolol concentrations were below the detection limit when a 5% patch was applied to the same skin area in all four subjects, except for one in whom the bioavailability was 23.6%. Weak erythema developed at the application site in all of the volunteers after application of the 20% (w/v) patch. However, erythema did not develop in any volunteer when the 5% patch was applied. The β-blocking effect was determined by exercise testing. Similar plasma levels generated similar changes in exercise-induced heart rate after the transdermal and intravenous administration of timolol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315551
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  • 6
    Electronic Resource
    Electronic Resource
    Extensive spinal necrosis with spinal leptomeningeal dissemination of cerebral astrocytoma (1988)
    Springer
    Acta neurochirurgica 93 (1988), S. 146-148 
    Details
    ISSN: 0942-0940
    Keywords: Glioma ; spinal leptomeningeal metastasis ; myelomalacia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 58-year-old male with malignant astrocytoma in the right parietal lobe developed ascending spinal dysfunction 15 months after subtotal resection of the primary lesion. He was treated by postoperative radiation and combined chemotherapy. Autopsy revealed extensive spinal necrosis affecting the level below the lower cervical region. Microscopic examination demonstrated diffuse leptomeningeal metastasis of glioma cells to the whole spine. There was no previous report in the literature of massive myelomalacia attributable to leptomeningeal dissemination an astrocytic supratentorial tumour. Clinical and neuropathological findings suggested that disturbance of venous drainage of the spinal cord might be responsible for myelomalacia in this case.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402898
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  • 7
    Electronic Resource
    Electronic Resource
    Intracranial invasion of scalp carcinoma (1989)
    Springer
    Acta neurochirurgica 98 (1989), S. 66-69 
    Details
    ISSN: 0942-0940
    Keywords: Burn scar ; squamous cell carcinoma ; scalp tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Among 10 patients with squamous cell carcinoma admitted to our hospital, 5 showed intracranial invasion and 4 died with regrowth of intracranial tumour 9 to 24 months after incomplete extirpation of tumour. We reviewed our experience in the management of advaned scalp carcinoma, from neurosurgical and neuroradiological points of view. Durai invasion failed to be removed completely because of involvement of the middle part of the superior sagittal sinus. Therefore, total resection, facilitated by early detection prior to intracranial invasion, is mandatory for successful treatment of these scalp carcinomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01407179
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  • 8
    Electronic Resource
    Electronic Resource
    Modified bifrontal interhemispheric approach to aneurysms of the anterior communicating artery with the use of a trephine craniotomy (1993)
    Springer
    Acta neurochirurgica 125 (1993), S. 127-131 
    Details
    ISSN: 0942-0940
    Keywords: Anterior communicating artery aneurysms ; microsurgical approach ; interhemispheric approach
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A modified microsurgical bifrontal interhemispheric approach (small trephine craniotomy) for clipping of aneurysms of the anterior communicating artery (ACoA) is described. This approach has been used in a series of 23 patients with ACoA and 2 patients with distal anterior cerebral artery aneurysms. Feasibility, indications and problems related to this approach to ACoA aneurysms are assessed. Twenty-one patients (84%) made an excellent or good recovery. The result was poor in an 80-year-old patient who was in grade 3 pre-operatively. Three patients of this series died: one of them was pre-operatively in grade 4 and died from pneumonia; the other two died as consequence of unrelated ailments. Incidence and extent of vasospasm was within the normal range, corresponding to the amount and distribution of subarachnoid blood clots. From our experience it can be concluded that this approach is safe and feasible for patients with ACoA aneurysms graded 1–2 (Hunt-Kosnik's grading system) and evaluated as group 1–2 of Fisher's CT classification. But it is not recommended for patients with larger amounts of subarachnoid blood clots. Advantages of this microapproach to ACoA aneurysms are: a) minimal brain damage, b) adequate visualization and anatomical orientation, c) preservation of the olfactory nerves and the gyrus reclus, d) reduced operative time, e) easy clip application to aneurysms pointing in any direction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401839
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  • 9
    Electronic Resource
    Electronic Resource
    Immunosuppressive acidic protein in patients with brain tumours: A preliminary report (1987)
    Springer
    Acta neurochirurgica 86 (1987), S. 42-49 
    Details
    ISSN: 0942-0940
    Keywords: Immunosuppressive acidic protein ; brain tumours ; tumour marker
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present investigation was conducted to document the serum concentrations of immunosuppressive acidic protein (IAP) in patients with intracranial tumours utilizing the single radial immunodiffusion method. Among 46 pre-operative patients, elevated serum levels of IAP were found in nine of 16 patients with gliomas, six of nine patients with metastasis, and two of 21 patients with non-glial, histologically benign intracranial tumours. The mean value of serum IAP in glial or metastatic tumours was found significantly higher than that of either non-glial or normal individuals. It was postulated that serum IAP levels could correlate with a grade of anaplasia and malignancy of the tumour. And it was also of note that serum IAP levels appeared to have a tendency to decrease in response to the treatment. In addition, serum IAP levels were found correlated with the clinical condition and course of disease as evaluated by performance status and erythrocyte sedimentation rate. Therefore, it was suggested that measurement of serum IAP could be, at least in part, useful in validating the histologic analysis of brain tumours, in following responses to treatment when used as a tumour indicator, and in monitoring the progress of the disease in patients in terms of performance status.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01419503
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  • 10
    Electronic Resource
    Electronic Resource
    A correlation between serum immunosuppressive acidic protein and altered immunocompetence in patients with brain tumours (1990)
    Springer
    Acta neurochirurgica 103 (1990), S. 52-61 
    Details
    ISSN: 0942-0940
    Keywords: Brain tumour ; immunology ; immunosuppressive acidic protein ; lymphocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present investigation was conducted to document a correlation between the serum levels of immunosuppressive acidic protein (IAP) and depressed lymphocyte responsiveness to mitogens in vitro in patients with intracranial tumours, and to delineate the possible roles of IAP upon immunocompetence in these patients. It was thought that high concentrations of IAP present in the serum of brain-tumour patients may play a significant role in the immunosuppression seen in this patient population. The effect of IAP upon mitogen-stimulated lymphocyte function was evaluated by tritiated (3H)-thymidine incorporation. Lymphocytes from both 30 patients with intracranial tumours and 30 normal individuals were incubated for 90 hours in culture medium in the presence of three mitogens: phytohaemagglutinin (PHA), concanavalin A (Con A), and pokeweed mitogen (PWM). Lymphocytes obtained from patients with brain tumours and cultured in autologous serum displayed a significant depression of3H-thymidine incorporation, as was observed in previous studies. In addition, a significant suppression of mitogen-induced activation of the normal lymphocytes was demonstrated in the presence of allogeneic patients' serum and the percentage of inhibition was found significantly proportional to the IAP concentrations. Furthermore it was also demonstrated that increased levels of serum IAP could significantly correlate with two in vivo aspects of impaired cellular immunity: the decreased lymphocyte counts in the peripheral blood and diminished cutaneous delayed hypersensitivity reactions measured by purified protein derivative (PPD) skin test reactivity. On the other hand, an attempt was also made to investigate changes in humoral immunity and immunoglobulin concentrations were observed not to correspond to the serum IAP levels. These studies suggest a possible connection between serum IAP levels and altered cellular immune competence in brain-tumour patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01420192
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