ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
This study evaluated the potential of the PCL (poly [removed info]-caprolactone)/HA(Hydroxyapatite)composite materials as a scaffold for bone regeneration. For this, we fabricated scaffolds utilizingsalt leaching method. The PCL/HA composite scaffolds were prepared with various HA contents(20wt%, 40wt%, 60 wt %). To ensure the potential for the scaffolds, porosity tests were conductedalong with SEM observations. The porosity decreased with the increase of the contents of HAparticles. The porosity of the composite with the highest contents of HA was still adoptable (~85%).In addition, the PCL/HA composite scaffolds were evaluated for their ability of osteogenicdifferentiation with human bone marrow stromal cell (hBMSC) in vitro. Alkaline phosphatase(ALP) activity, markers for osteoblastic differentiation, and total protein contents were evaluated inhBMSCs following 14 days of cultivation. The addition of HA particles enhanced proliferation ofhBMSC during the test. Also, the differentiation ability of the cells was increased as HA particleswere added. In this study, we concluded that PCL/HA composite scaffolds has great potential as ascaffold for bone tissue engineering
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/54/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.342-343.369.pdf
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