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  • 1
    ISSN: 0942-0940
    Keywords: [111In-DTPA-D-Phel]-octreotide ; somatostatin receptors ; meningioma ; brain tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have studied prospectively 47 patients with CNS tumours including 16 meningiomas and 33 other tumours using combined111In-octreotide and99mTc-DTPA brain scintigraphy.111In-octreotide scintigraphy was used to image somatostatin receptors (SSR) and99mTc-DTPA scintigraphy was used to assess the integrity of the blood-brain barrier (BBB). A total of 32 tumours (65%) were detected. All SSR positive tumours also had positive99mTc-DTPA scans and all SSR negative tumours were negative on99mTc-DTPA scans. Among the tumours located outside the BBB, all meningiomas and two out of six schwannomas were positive on combined SSR/99mTc-DTPA scintigraphy. Among the tumours located inside the BBB, seven out of nine gliomas grade I–III were negatitve, whereas all glioblastomas were positive. Other positive tumours included one malignant non-Hodgkin lymphoma and two cerebral metastases. SSR scintigraphy alone was non-specific in the diagnosis of meningiomas, as 16 non-meningiomatous tumours also had positive SSR scans probably due to a breakdown of the BBB (excluding the malignant lymphoma). Measuring the tumour-to-background ratio on SSR scans improved specificity, but sensitivity was decreased below 70% because some meningiomas were only slightly positive. Only the ratio of SSR scintigraphy to conventional99mTc-DTPA brain scintigraphy (SSR-to-BS index) allowed a reliable differentiation of meningiomas from other CNS tumours, most notably from schwannomas (sensitivity: 94%; specificity: 100%). Our results support the usefulness of combined SSR and conventional brain scintigraphy in the noninvasive pre-operative diagnosis of meningiomas.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In previous studies, tropisetron has been shown to accelerate gastric emptying of a solid meal. However, it is uncertain whether other specific 5-hydroxytryptamine-3 receptor antagonists, such as ondansetron, also have a gastroprokinetic effect in humans.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To evaluate the effect of ondansetron on gastric half-emptying time (T1/2) of a solid meal, gastric myoelectrical activity and hormone levels in 14 healthy volunteers.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:In a placebo-controlled, randomized, crossover study, we investigated the effects of ondansetron (8 mg intravenously) on the gastric emptying of solids (by scintigraphy), gastric myoelectrical activity (by electrogastrography) and the post-prandial release of cholecystokinin, gastrin, human pancreatic polypeptide, gastric inhibitory polypeptide, vasoactive intestinal polypeptide, motilin, substance P and galanin.〈section xml:id="abs1-4"〉〈title type="main"〉Results:The average T1/2 values were 86 min and 85.5 min without lag time (P=0.082) and 92 min and 93 min with lag time (P=0.158) for the placebo and ondansetron treatments, respectively. The average T1/2 of female volunteers was significantly longer than that of male volunteers. The dominant gastric electrical frequency and hormone plasma concentrations were not altered by ondansetron.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:Ondansetron did not affect the gastric emptying of solids, the dominant gastric electrical frequency or the plasma concentrations of the analysed gastrointestinal peptides.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Neuroradiology 6 (1973), S. 27-31 
    ISSN: 1432-1920
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les auteurs ont étudié des scintigrammes cérébraux en série chez 196 malades porteurs de tumeurs vérifiées. En plus de l'analyse des caractéristiques observées au cours des radio-angiographies (stade I), l'intensité de l'activité de la tumeur au stade II et III (scintigramme précoce et tardif) fut comparée et classifiée. Les trois groupes d'intensité obtenus, c'est-à-dire II〉III, II=III et II〈III, furent ensuite analysés quant au type de la tumeur. Dans le groupe II〉III, 56% des tumeurs étaient des angiomes. Dans le groupe II=III, 45% des tumeurs étaient des méningiomes. Dans le groupe II〈III, 41% des tumeurs étaient des métastases et 47% des gliomes malins. Ces résultats encouragent à poursuivre l'utilisation de la combinaison des scintigrammes précoces et tardifs dans l'étude du diagnostic spécifique des tumeurs cérébrales. Il faut noter cependant que le comportement de la tumeur au stade I (radioangiographie) a également une signification diagnostique et est particulièrement utile dans la différenciation des tumeurs avec les lésions vasculaires.
    Abstract: Zusammenfassung Es wurden die Serien-Hirnszintigramme von 196 Patienten mit nachgewiesenen Hirntumoren untersucht. Dabei zeigte es sich, daß der Vergleich von den frühen Szintigrammen zu den späten Szintigrammen eine bessere Genauigkeit bei der Bestimmung der Art-Diagnose des Tumors ergab. Dies ist von besonderem Wert bei der Differenzierung eines Tumors zu einer vasculären Läsion.
    Notes: Summary The serial brain scintigrams in 196 patients with proven tumors have been reviewed. In addition to an analysis according to the characteristics observed during the CRAG (Stage I), the intensity of tumor activity in Stages II and III (early and late scintigrams) were compared and classified. The resulting three intensity groups, i.e. II〉III, II=III, and II〈III, were then further analyzed according to tumor type. Of those tumors with II〉III 56% were angiomas, of those tumors with II=III 45% were meningiomas, and of those with II〈III 43% were metastases and 43% malignant gliomas. These results encourage the further use of the combination of early and late scintigrams in the type-specific diagnosis of brain tumors. It must be stressed, however, that the tumor behavior in Stage I (CRAG) also has diagnostic significance and is particularly valuable in the differentiation of tumors from vascular lesions.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1569-8041
    Keywords: chemotherapy ; cervical ; germ cell tumor ; prognosis ; surgery ; teratoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report a case of a man presenting with a cervical malignant teratoma and a chondrosarcomatous rib metastasis. He was alive and free of recurrence five years and 10 months (= 70 months) after resection of the primary mass, followed by chemotherapy and subsequent resection of the rib tumor. This is the 35th patient reported in the literature and the first description in which an ‘adjuvant’ or primary chemotherapy was used. Previous patients with a cervical malignant teratoma, reported after lethal outcome, had survivals of one to 22 months (median nine months). In all patients with a preoperative clinical impression of an aggressive, differentiated or undifferentiated malignancy, the definite diagnosis of teratoma could only be made histologically. By analogy to germ cell tumors, the prognosis of malignant teratoma might be improved if complete excision is combined with new, adjuvant chemotherapy protocols for germ cell tumors. Lessons learned from this case are placed in the context of germ cell tumors in general and of non-gonadal malignant teratomas in particular.
    Type of Medium: Electronic Resource
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