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  • 1
    Publication Date: 2021-02-05
    Language: English
    Type: article , doc-type:article
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 34 (1962), S. 733-736 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 37 (1965), S. 1280-1281 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 33 (1961), S. 1737-1741 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 38 (1966), S. 1453-1457 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 37 (1965), S. 1245-1249 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Analytical chemistry 38 (1966), S. 480-484 
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Macromolecules 28 (1995), S. 3282-3289 
    ISSN: 1520-5835
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Algorithmica 22 (1998), S. 235-249 
    ISSN: 1432-0541
    Keywords: Key words. Dynamic algorithm, Graph algorithm, Shortest path, Minimum-cost path, Planar graph.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract. In this paper we give a fully dynamic approximation scheme for maintaining all-pairs shortest paths in planar networks. Given an error parameter $\epsilon$ such that $0〈\epsilon$ , our algorithm maintains approximate all-pairs shortest paths in an undirected planar graph G with nonnegative edge lengths. The approximate paths are guaranteed to be accurate to within a 1+ $\epsilon$ factor. The time bounds for both query and update for our algorithm is O( \epsilon -1 n 2/3 log 2 n log D) , where n is the number of nodes in G and D is the sum of its edge lengths. The time bound for the queries is worst case, while that for the additions is amortized. Our approximation algorithm is based upon a novel technique for approximately representing all-pairs shortest paths among a selected subset of the nodes by a sparse substitute graph.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 45 (1996), S. 737-744 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Spinalanästhesie ; Ropivacain ; Analgesieeffizienz ; Dosisfindung ; Key words Spinal anaesthesia ; Ropivacaine ; Efficacy of analgesia ; Appropriate dosage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Several clinical studies have demonstrated the efficacy of ropivacaine in different regional anaesthesia techniques, e.g., epidural anaesthesia. However, the efficacy of ropivacaine for spinal anaesthesia has only been demonstrated in animal experiments up to now. The objective of this study was the investigation of the efficacy and appropriate dosage of isobaric ropivacaine for spinal anaesthesia in humans. Methods. In a randomised, double-blind study, spinal anaesthesia with ropivacaine was performed in two groups of 20 patients each (group I: ropivacaine 0.5%, 3 ml=15 mg; group II: ropivacaine 0.75%, 3 ml=22.5 mg). Spinal anaesthesia was performed with a 25 G needle in the midline at the L3–4 level with the patient sitting up, preceded by local infiltration of 2 ml mepivacaine 0.5%. Spread and regression of sensory block were assessed by testing loss of sensation to cold. Development of motor block was concurrently recorded by means of a modified Bromage scale (motor block was assessed in the hip, knee and ankle joints and recorded as complete or incomplete according to degree). The findings are presented as mean values. Results. Onset of analgesia to L5 and S1 was 2 min in both groups, and to T12 and T10 8 and 12.5 min, respectively, in group I and 12.5 and 13 min, respectively, in group II; these differences were not statistically significant. Mean maximum spread was to T10 in group I and T8 in group II. Onset of maximum cranial spread was 24 min in group I and 32 min in group II. Duration of analgesia in the segments relevant to the performed operations varied in group I between 1.5 and 5.7 h (S3 4.9, S1 5.7, L4 5.4, L2 3.0, T12 2.0, T10 1.6, T8 1.5 h) and in group II between 1.8 and 5.9 h (S3 5.4, S1 5.9, L4 5.7, L2 4.1, T12 2.9, T10 2.3, T8 1.8 h). These differences were significant in the segments S3, L3, L2, L1, T12, and T10. In 5 patients (20%) in group I adequate analgesia for the planned surgical intervention was not obtained. In 4 of these 5 patients the required spread of the spinal block was not reached; in 2 general anaesthesia had to be performed and in 2 the required analgesia could be obtained by administration of an analgesic (fentanyl). In the 5th patient the level of spinal block was sufficient for the planned operation, however, the quality of analgesia was not, i.e., additional analgesics were required. In the group that received the 0.75% solution additive analgesics were necessary in 1 patient (5%) because a sufficient level of anaesthesia for the planned operation was not obtained. In group I all patients had a complete motor block in all three joints (hip, knee, and ankle); in group II, however, the motor block was incomplete in 6 patients. This difference between the 2 groups was statistically significant. Onset of motor block of hip, knee, and ankle joints occurred after 10, 15, and 15 min, respectively, in group I and 10, 12, and 15 min, respectively, in group II. These differences were not statistically significant. Duration of motor block in the three joints was significantly longer (3.4, 2.8, and 3.8 h)in group II than in group I (2.4, 1.9, 2.7 h). Statistically significant changes in systolic and diastolic blood pressures (BP) and heart rate (HR) were recorded in both groups in the course of the study period. Relative BP changes were assessed in the individual patients. There were no statistically significant changes between the two groups with regard to relative changes in systolic and diastolic BP and HR. Bradycardia occurred a total of 13 times in 10 patients in group I and in 11 patients in group II. A BP decrease of 〉20% was measured in 1 patient in each group. Twelve of the 40 patients complained a headache in the first 6 days; in this respect the groups did not differ significantly. There was no difference between male and female patients with regard to side effect profile. Conclusion. At concentrations of 0.5% and 0.75%, ropivacaine results in long-lasting spinal anaesthesia. Duration of analgesia as well as duration and degree of motor block increase with the higher concentration. Neurotoxic effects of the local anaesthetic were not observed. A dose of 3 ml ropivacaine 0.75% seemed to be suitable for the gynaecologic and urologic operations (Table 3) with regard to efficacy of analgesia and local anaesthetic spread.
    Notes: Zusammenfassung In einer doppelblind durchgeführten Studie wurden Ropivacain 0,5% isobar (Gruppe I: 3 ml–15 mg; n=20) und Ropivacain 0,75% isobar (Gruppe II 3 ml–22,5 mg; n=20) zur Spinalanästhesie verglichen. Der Median der Latenzzeit der Analgesie für die Segmente L5 und S1 betrug 2 min für die beiden Gruppen, für die Segmente Th12 bzw. Th10 betrugen diese Zeiten 8 bzw. 12,5 min für die Gruppe I und 12,5 bzw. 13 min für die Gruppe II. Die maximale Ausbreitung lag in Gruppe I bei Th10 und in Gruppe II bei Th8. Der Median der Dauer der Analgesie variierte in der 0,5%-Gruppe zwischen 1,5 und 5,7 h und in der 0,75%-Gruppe zwischen 1,8 h und 5,9 h. In der Gruppe I konnte bei 5 Patienten (20%) die notwendige Analgesie nicht erreicht werden. In der Gruppe II mußte bei einem Patienten (5%) zusätzliche Analgetika verabreicht werden. In der Gruppe I erreichten alle Patienten eine komplette motorische Blockade; in der Gruppe II war die Blockade jedoch bei 6 Patienten unvollständig. Die Dauer der motorischen Blockade an Hüft-, Knie- und Fußgelenk war in der Gruppe I signifikant länger als in der Gruppe II. Ropivacain ist ein Lokalanästhetikum, das nach intrathekaler Applikation zu Spinalanästhesien führt, die in ihrem Wirkprofil den Spinalanästhesien mit Bupivacain ähnlich sind. Eine niedrige Dosierung von 15 mg kann eine vergleichbare Analgesie bei tieferer Analgesiehöhe hervorrufen bei schwächerer motorischer Blockade und schnellerer Regressionszeit.
    Type of Medium: Electronic Resource
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