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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 29 (1964), S. 2813-2815 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 22 (1972), S. 183-189 
    ISSN: 1432-0533
    Keywords: β-β′-Iminodipropionitrile (IDPN) ; Axonal Balloons ; Protein Turnover Autoradiography ; H3-Leucine ; Spinal Motoneurons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Autoradiography was performed in order to envisage the turnover of H3-leucin labeled protein in the perikarya of spinal motoneurons and in the axonal balloons formed after repeated administrations of IDPN (β-β′-iminodiproprionitrile) in rats. These results suggested that (1) there was no significant, if any,in situ protein synthesis within the axon balloons, (2) the protein turnover was not appreciably altered in the perikarya of the control and IDPN-intoxicated rats, and (3) the labeled protein collected in the axon balloons seemed to be transported from the perikarya to which they were linked with short axonal segments (30 μ in average length).
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 68 (1982), S. 47-56 
    ISSN: 1432-1424
    Keywords: hydrostatic pressure ; potassium flux ; erythrocyte membrane ; water of hydration ; anion effect ; thermodynamic analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The effects of hydrostatic pressure and temperature on the three components of K+ uptake in human red cells have been investigated, using ouabain and bumetanide to distinguish between the pump, passive diffusion and cotransport. The pressure sensitivity for passive diffusion has been shown to depend on the counter-ion present. The order of this effect, Cl−〉Br−〉NO 3 − 〉I−, is the same as for the ionic partial modal volumes and the Hofmeister series. We have analyzed our experimental results thermodynamically, and propose a model for the activated transition-state complex of the potassium ion which involves the loss of water molecules from the secondary hydration shell, cosphere II.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 55 (1980), S. 123-131 
    ISSN: 1432-1424
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Members of four homologous series of tetra-alkyl ammonium bromides (R 3N+(CH2) n−1·CH3Br− whereR=H, CH3 or C2H5 andR′N+H3Br− whereR′ represents the isomeric butyl series) have been synthesized and tested as sodium pump inhibitors, measured as ouabain-sensitive K+ influx, and as hemolytic agents on human red cells. Potency for both effects is presented graphically, plotting the logarithm of the concentration for half maximal effect against alkyl chain length. Both hemolysis and pump inhibition studies yielded a biphasic response consisting of two good straight lines, with effectiveness increasing up to C10–12 and then remaining constant up to C20. For hemolysis the alkyl ammonium series was most effective. The calculated free-energy change per methylene group was the same for three series of compounds, but the free-energy contribution from the headgroup was lower for the ammonium series. In contrast, although pump inhibition studies also yielded simple biphasic plots, inhibition occurred at 3- to 50-fold lower concentrations and there were significant differences between the three series, both in the free-energy changes per methylene group and in the headgroup contributions. We have analyzed these results thermodynamically to take account of hydrophobic interactions and the conformation of the alkyl chains.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 39 (1974), S. 483-486 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 248 (1974), S. 401-402 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We have been investigating a number of organic compounds in which the e-e interaction is expected to be large. Here we wish to report one of a potentially large class of organic compounds which has 'metallic' electrical properties over a large temperature range. This compound, we believe, is an ...
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 286 (1980), S. 403-404 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Surprisingly few data are available on the effects of temperature on Na and K transport in human erythrocytes. This may be due in part to the presence of at least three components of Na and K movement in human red cells. These can be resolved as the ouabain-sensitive Na-K pump1'2, the ...
    Type of Medium: Electronic Resource
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